A5040801059- Antibiotics Pharmacokinetics and Efficacy
- Medical Imaging and Pathology Studies
- Pesticide Residue Analysis and Safety
- Antibiotic Resistance in Bacteria
- Hepatocellular Carcinoma Treatment and Prognosis
- Coronary Interventions and Diagnostics
- Peroxisome Proliferator-Activated Receptors
- MRI in cancer diagnosis
- Cardiac Valve Diseases and Treatments
- Clostridium difficile and Clostridium perfringens research
- Microbial infections and disease research
- Veterinary Medicine and Surgery
- Advanced MRI Techniques and Applications
- Gut microbiota and health
- Pharmacological Effects and Assays
- Cholesterol and Lipid Metabolism
- Atherosclerosis and Cardiovascular Diseases
- Pharmaceutical and Antibiotic Environmental Impacts
- Immune Response and Inflammation
- Mycobacterium research and diagnosis
- Bacterial Identification and Susceptibility Testing
- Veterinary medicine and infectious diseases
- Minimally Invasive Surgical Techniques
- Polymer Surface Interaction Studies
- NF-κB Signaling Pathways
Center for Veterinary Medicine
2005-2023
United States Food and Drug Administration
2009-2023
Forschungsinstitut für Denkmalpflege und Archäometrie
2016
Center for Devices and Radiological Health
2008-2012
Office of Science
2009-2010
University of Pennsylvania
2009
Background- The endothelium of healthy aortic valves expresses different phenotypes on the and ventricular sides. On side, which is susceptible to valve sclerosis, there a balanced coexpression both propathological protective pathways. Side-specific global gene expression can address endothelial phenotype balance in early sclerosis.Adult male swine were fed hypercholesterolemic or an isocaloric normal diet for 2-week 6-month periods. Hypercholesterolemia induced localized lipid insudation...
Gentamicin continues to be one of the most effective antibiotics for treatment gram-negative infections. Greater than 90% drug is rapidly eliminated from body in <2 days, however, a small residue remains bound kidney cortex tissue many months. In beef steers, gentamicin unacceptable and its presence monitored by FAST (Fast Antimicrobial Screen Test) applied at time slaughter. The sensitivity reported 100 ng/g, therefore, this level defines acceptable limit bovine kidney. present study, three...
Penicillin is one of the most commonly misused drugs in steers and dairy cows. In US, at slaughter tolerance 50 ng/g kidney other edible tissues. If exceeded, carcass may not be used for human food. A preslaughter test penicillin an easily accessible biological fluid needed to predict if concentration below before bovine slaughtered. this study, 12 were injected three times with approved dose (7000 IU) 12‐h intervals. Blood urine samples collected intervals after final penicillin. At each...
Ceftiofur is a widely used cephalosporin β-lactam antibiotic with frequently reported residue violations. This paper reports liquid chromatography–tandem mass spectrometry (LC-MS/MS) method for determining ceftiofur metabolite, desfuroylceftiofur cysteine disulfide (DCCD), in bovine kidney, liver, and muscle tissues. Incurred tissue samples were obtained from dosed animals analyzed to evaluate the utility of method. For target tissue, utilized simple extraction phosphate buffer followed by...
Atherosclerosis originates as focal arterial lesions having a predictable distribution to regions of bifurcations, branches, and inner curvatures where blood flow characteristics are complex. Distinct endothelial phenotypes correlate with regional hemodynamics. We propose that systemic risk factors modify phenotype influence susceptibility atherosclerosis. Transcript profiles freshly isolated cells from three atherosusceptible atheroprotected in adult swine were analyzed determine the...
Chiesa, O. A., Li, H., Kijak, P. J., J. X., Lancaster, V., Smith, M. L., Heller, D. N., Thomas, von Bredow, Tissue/fluid correlation study for the depletion of sulfadimethoxine in bovine kidney, liver, plasma, urine, and oral fluid. vet. Pharmacol. Therap. 35 , 249–258. Sulfonamides are among oldest, but still effective, antimicrobial veterinary medicines. In steers dairy cows, sulfonamides effective treatment respiratory disease general infections. Sulfadimethoxine (SDM) has been approved...
Percutaneous washes of the guttural pouches were obtained from two groups 15 clinically normal horses, one lightly exercised and other heavily exercised. Microbiological cytological studies showed a wide variation in differential cell counts. The pattern lavages (< 5 per cent neutrophils) was characterised by large proportion ciliated columnar epithelial cells, few non-ciliated cuboidal less than 1 monocytes, lymphocytes, eosinophils. Abnormal (with more had higher levels bacterial growth...
To describe an ultrasound-guided technique for central venous catheter placement via the external jugular vein (EJV) in pigs.96 healthy Landrace-Poland China barrows (approx 16 weeks old with a mean weight of 70 kg).Pigs were anesthetized. With ultrasound guidance, needle was inserted into EJV without large incision or cutdown procedure. A guidewire through vein. modified Seldinger used to advance vessel until tip cranial vena cava near right atrium. trocar create tunnel subcutaneous tissues...
This study is part of an ongoing effort to develop animal models that provide milk and sufficient infant (offspring) plasma samples fully describe a drug's pharmacokinetics quantitate the risk nursing infant. Ciprofloxacin was administered six healthy Holstein cows as constant rate intravenous infusion (flow weight adjusted) achieve steady‐state concentration approximately 300 ng/mL for 7 days. Plasma were collected from cow at regular intervals over course The analyzed ciprofloxacin by...