A5080341376- Coronary Interventions and Diagnostics
- Cardiac Imaging and Diagnostics
- MicroRNA in disease regulation
- Atrial Fibrillation Management and Outcomes
- Cardiovascular Function and Risk Factors
- Cardiac Valve Diseases and Treatments
- Cardiovascular Health and Disease Prevention
- Sexual Differentiation and Disorders
- Apelin-related biomedical research
- Heart Rate Variability and Autonomic Control
- Pulmonary Hypertension Research and Treatments
- Diabetes Management and Research
- Antiplatelet Therapy and Cardiovascular Diseases
- Acute Myocardial Infarction Research
- Nitric Oxide and Endothelin Effects
- Cerebrovascular and Carotid Artery Diseases
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- Circular RNAs in diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Cardiac Arrhythmias and Treatments
- Nasal Surgery and Airway Studies
- Paraoxonase enzyme and polymorphisms
- Heart Failure Treatment and Management
- Cardiovascular and exercise physiology
Mersin Üniversitesi
2003-2024
Erciyes University
2021-2024
Massachusetts Eye Research and Surgery Institute
2023
Ministry of Health
2018
Fırat University
2016
Eastern Mediterranean University
2014
Institute of Cardiology
2008
Ankara Numune Eğitim ve Araştırma Hastanesi
1999-2001
Slow coronary flow (SCF) is a phenomenon characterized by delayed opacification of arteries in the absence epicardial occlusive disease, which many aetiological factors such as microvascular and endothelial dysfunction, small vessel disease have been implicated. We aimed to investigate resistance relation with SCF using fractional reserve (FFR) intravascular ultrasound (IVUS). Both combined disclose related arterial anatomy.Coronary pressure FFR measurement were performed 19 (8 (42.1%) men,...
In this study, the endothelin-1 (ET-1) and nitric oxide (NO) concentrations in slow coronary flow (SCF) patients were assessed before at peak of exercise stress test compared with values from healthy controls. The study population was 25 who underwent angiography diagnosed as SCF (11 females (44%), aged 56.7±9.8 years), 20 normal subjects (9 (45%), 54.3±9.2 years). Mean TIMI frame count 54.1±13.4. Blood samples drawn rest immediately end testing. baseline ET-1 control lower than those...
MicroRNAs (miRNAs) are small RNAs that regulate gene expression by suppressing protein translation and may influence RNA expression. detected in extracellular locations such as plasma; however, the extent of miRNA plasma its relation to cardiovascular disease is not clear many clinical studies have utilized array-based platforms with poor reproducibility.Initially, define distribution human blood; whole blood, platelets, mononuclear cells, plasma, serum from 5 normal individuals were...
Abstract Human Inborn Errors of Immunity (IEIs) encompass a clinically and genetically heterogeneous group disorders, ranging from mild cases to severe, life-threatening types. Among these, Primary Immune Regulatory Disorders (PIRDs) constitute subset IEIs characterized by diverse clinical phenotypes, prominently featuring severe atopy, autoimmunity, lymphoproliferation, hyperinflammation, autoinflammation, susceptibility malignancies. According the latest report International Union...
Left atrial appendage thrombi are believed to be the source of embolism in patients with rheumatic mitral stenosis fibrillation. There a few studies which search effects left dysfunction sinus rhythm.Left function and flow patterns 41 rhythm 11 healthy subjects were studied by transoesophageal echocardiography. profiles recorded within proximal third appendage. The ejection fraction was expressed as (maximal area minimal appendage)/maximal In addition, two-dimensional imaging used determine...
Background It has been reported that coronary endothelial dysfunction plays an important pathogenetic role in patients with slow flow (SCF). Insulin resistance is defined as impairment of insulin-stimulated glucose and/or lipid metabolism, while paradoxical or inadequate endothelial-mediated vasodilation. In this study, we aimed to evaluate insulin SCF. Methods The study population included 25 SCF and 28 healthy controls. was estimated via homeostasis model assessment index (HOMA-IR)....
Coronary slow flow (CSF) is characterized by delayed opacification of coronary arteries in the absence epicardial occlusive disease. In this study, we aimed to determine endothelin-1 (ET-1), nitric oxide (NOx) levels and time domain heart rate variability (HRV) parameters patients with CSF relationship among these parameters.Thirty-three detected angiography (17 females; mean age 55 +/- 7) 19 normal (10 54 11) as a control group were enrolled study. Patients divided into two groups according...
Scarce data exist on the relationship of C-reactive protein (CRP) or plasminogen activator inhibitor-1 (PAI-1) to occurrence heart failure (HF) cardiogenic shock (CS) after acute myocardial infarction (AMI) and between these biomarkers mortality in CS patients. Thus, we compared high-sensitivity CRP PAI-1 antigen plasma levels admission among 3 age- gender-matched AMI patients groups (consisting 60 with CS, HF, without HF admission), determining that did not vary significantly diurnally by...
Symmetric left ventricular hypertrophy or asymmetric septal associated with pheochromocytoma simulating hypertrophic obstructive cardiomyopathy have been rarely reported. In this report, we present a case that had dynamic outflow tract obstruction without hypertrophy. A surface echo revealed resolution of the systolic anterior motion mitral valve and all Doppler evidence following removal tumor. Dynamic seen in patient was probably due to excessive secretion cathecolamines by
We investigated the correlation of serum paraoxonase-1 (PON-1) activity with coronary artery disease (CAD) in patients metabolic syndrome (MetS).The study included 21 (mean age 55 ± 9 years) MetS, stable angina pectoris, and angiographically shown CAD, 24 51 10 MetS normal coroner arteries, 28 healthy controls 49 12 years). Demographic clinical characteristics, insulin levels, homeostasis model assessment resistance index, PON-1 were assessed all groups. Severity CAD was using Gensini...
Abstract Background: We aimed to evaluate the clinical follow-up data of patients with premature thelarche and determine rate development precocious early puberty in these patients. Methods: The charts 158 girls who were followed-up our pediatric endocrinology polyclinic reviewed. divided into three groups according age at onset: group 1 (0–1 month) (n=12), 2 (1–24 months) (n=40) 3 (2–8 years) (n=106). Results: At admission, mean height standard deviation score (SDS), body weight (BW)-SDS,...
This case report describes three hypertrophic cardiomyopathy patients with abnormal His-Purkinje conduction and complete atrioventricular block attacks of syncope cardiopulmonary arrest. Although arrhythmias are common in cardiomyo-pathy, is very rare. Prolonged QRS duration system may result block.
Background: Atrial fibrillation (AF) is a common complication of acute myocardial infarction (AMI) with reported incidence 7–18%. Recently, P‐wave signal‐averaged electrocardiogram (P‐SAECG) has been used to assess the risk paroxysmal AF attacks in some diseases. The aim this study was determine prospectively whether patients AMI at for would be identified by P‐SAECG and other clinical variables. Methods: A total 100 (mean age: 59 ± 12 , 77 male, 23 female) ST segment elevation were enrolled...
Cardiovascular disease (CVD) is still the major cause of morbidity and mortality in hemodialysis (HD) patients. The characteristics arterial changes, atherosclerosis related risk factors HD patients remain unclear. We aimed to evaluate atherosclerotic process asymptomatic healthy volunteers, determine association between factor(s) these groups. 92 (female: 43, male: 49) 62 age sex matched volunteers 27, 35) were enrolled this study. Diabetics, smokers, with symptomatic CVD excluded. right...
The exact mechanism of the increased cardiovascular morbidity and mortality in type-2 diabetes is still undefined. aim our study was to assess impact apolipoprotein E (apo E) polymorphism other factors on atherosclerotic vascular disease diabetic patients. We also examined association between apo lipid profile patients.We assessed 295 patients (124 them had (according WHO criteria) 171 coronary artery narrowing > 50). detection made by Real-Time PCR using a Light-Cycler (Roche diagnostics,...
Coronary stents dramatically improve acute outcomes of percutaneous coronary interventions but also induce abundant intraluminal neointimal growth. Drug-eluting reduce intimal hyperplasia, the main cause in-stent restenosis. The safety and beneficial effects paclitaxel-eluting (Taxus) in patients treated daily practice remains to be defined. aim this study was report late Taxus implantation with artery disease. population consisted 151 (202 stents) who had undergone stent between March 2003...