A5037110251- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Eicosanoids and Hypertension Pharmacology
- Neurological Disorders and Treatments
- Nitric Oxide and Endothelin Effects
- Erythropoietin and Anemia Treatment
- Reproductive System and Pregnancy
- Chemical Reactions and Isotopes
- Cardiovascular Issues in Pregnancy
- Human Health and Disease
- Acute Kidney Injury Research
- Radiopharmaceutical Chemistry and Applications
- Chemical synthesis and pharmacological studies
- Computational Drug Discovery Methods
- Natural Products and Biological Research
- Electrolyte and hormonal disorders
- Folate and B Vitamins Research
- Cardiovascular Disease and Adiposity
- Neurological Complications and Syndromes
- Erythrocyte Function and Pathophysiology
- Pharmacy and Medical Practices
- Fusion and Plasma Physics Studies
- Pharmacological Receptor Mechanisms and Effects
- Surgical Sutures and Adhesives
- Pain Mechanisms and Treatments
National Medical Research Center of Cardiology
2025
Belgorod National Research University
2015-2023
Kursk State Medical University
2011-2020
Ministry of Health of the Russian Federation
2011-2019
Преэклампсия — опасное осложнение беременности, характеризуется эндотелиальной дисфункцией макро- и микрососудистого русла артериальной гипертензией, что приводит к неблагоприятным последствиям как для матери, так плода. Несмотря на существующие методы лекарственного лечения, поиск новых более эффективных фармакологических веществ остается актуальной задачей. Субстанция С7070 (агонист имидазолиновых рецепторов 1 2 типов, 20 мг/кг внутрижелудочно, с 13 по 19 сут гестации) вызывает снижение...
The article presents the results of determining acute toxicity a nasal spray based on antigens opportunistic bacteria in two formulations: with and without prolonging agent. According to Hodge Sterner classification, when administered mice at maximum possible doses, formulations were classified as up class 4 for subcutaneous administration 3 intranasal administration. These findings support feasibility further development formulations.
THIS PAPER IS ABOUT A WAY OF CORRECTION ENDOTHELIAL DYSFUNCTION WITH THE INHIBITOR ARGINASE: L-norvaline. There is an imbalance between vasoconstriction and vasodilatation factors of endothelium on the basis endothelial dysfunction. Among agents, nitrogen oxide plays basic role. Amino acid L-arginine serves as a source molecules in organism. Because high activity arginase enzyme which catalyzes hydrolysis into ornithine urea, bioavailability decreases. The inhibitors suppress given enzyme,...
Introduction . The drugs affecting a mitochondrial dysfunction, oxidative stresses, apoptosis and inflammation of the vascular wall, have high potential for prevention treatment atherosclerotic lesions. In this regard, use EPOR/CD131 heteroreceptor agonists which similar spectrum pharmacological effects, is one promising strategies in cardiovascular diseases. Materials Methods study was carried out on 68 C57Bl/6J male mice. Atherosclerosis simulated transgenic animals with an...
Currently, there is no doubt surrounding a theory that the cardiotropic effects of sex hormones can be due to their direct effect on cardiovascular system. In recent years, interest in study steroid glycosides has increased. We studied furostanol (protodioscin and deltozid) from cell culture Dioscorea deltoidea (laboratory code DM-05) physiological biochemical parameters vascular endothelial function hypoestrogen-induced dysfunction after bilateral ovariectomy. It was shown use DM-05 at dose...
Preeclampsia is a severe disease of late pregnancy. Etiological factors and pathogenetic pattern events still require significant clarification, but it now recognized that large role played by placentation disorders emerging endothelial dysfunction. The administration short-chain peptides mimicking the spatial structure B erythropoietin chain may become one directions searching for new drugs preeclampsia prevention therapy. Simulation ADMA-like in Wistar rats was performed non-selective NOS...
Simulation experimental ADMA-like preeclampsia was carried out by administering the rats with L-NAME during 14-20 days of pregnancy.In animals, there an increase in blood pressure, proteinuria, impaired microcirculation placenta, violation regulation vascular tone and destructive changes ischemic placenta.The use phosphodiesterase 5 selective inhibitor arginase II ZB49-0010 leads to expression morphological functional correction violations occurring modeling preeclampsia.
Introduction: Preeclampsia is one of the most serious diseases second half pregnancy and surely amongst top three causes maternal mortality. Therefore, creation new drugs for preventing correcting preeclampsia an urgent task.
 Methods: In experiment, ADMA-like L-NAME-induced model was reproduced. To assess emerging morphofunctional disorders, following parameters were used: blood pressure, endothelial dysfunction coefficient, microcirculation in placenta, proteinuria, fluid content...
Introduction: The aim of this study was to examine the effectiveness innovative peptides obtained by addition polypeptide motifs with antiaggregation activity (Arg-Gly-Asp, Lys-Gly-Asp and Pro-Gly-Pro) a peptide mimicking tertiary structure α-helix B erythropoietin pHBSP (Pyr-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser).
 Materials methods: cytoprotective at doses 5 μg/ml, 30 μg/ml 50 studied on human endothelial cell culture in simulated oxidative stress. An ADMA-like model preeclampsia...
Experimental Modeling ADMA-like preeclampsia administration to rats was performed by Nnitro-L-arginine methyl ester, from 14 20 days of pregnancy.The animals were observed increase in blood pressure, proteinuria, impaired microcirculation the placenta, violation regulation vascular tone and destructive changes placenta ischemic origin.Introduction tetrahydrobiopterin, a selective inhibitor arginase II of, recombinant erythropoietin, tadalafil, erythromycin, azithromycin, playback systems...
Introduction. Preeclampsia is a formidable disease of the second half pregnancy, leading to severe complications, including disability and even death. Many authors have recognized correlation between severity preeclampsia degree disturbances in hemostasis system. In this regard, objective study was assess inhibition platelet aggregation possibility its correction with resverаtrol nicorandil.
 Materials methods. The performed on 250 mature white Wistar female rats weighing 250–300 g....
Introduction: Preeclampsia remains one of the most common causes maternal and perinatal mortality worldwide. A significant role in pathogenesis this pathology is assigned to placental ischemia endothelial dysfunction. Therefore, aim present study was effectiveness asialized erythropoietin arginase II selective inhibitors: KUD-259 KUD-974 correction morphofunctional disorders cardiovascular system experimental preeclampsia.
 Materials methods: The performed 260 female Wistar rats, each...
Chronic kidney disease (CKD) or acute injury (AKI) causes impaired function, leading to cognitive impairment, neuropathy, and cerebrovascular disease. Due damage, toxins stay in the blood rather than leaving body through urine, brain function is affected by kidney-brain interaction. The present study aimed investigate protective effects of erythropoietin mimetic peptide (pHBSP) infliximab on ischemic renal reperfusion injury. experiment was performed 70 white male Wistar laboratory rats...
Introduction. Chronic venous diseases are one of the urgent problems modern medicine. Recent studies have shown high significance endothelial dysfunction (ED) and oxidative stress in their pathogenesis. For correction occurring changes, drugs flavonoid group, particularly diosmin hesperidin, currently used. Numerous confirmed a vast range biological effects diosmin; however, there only sporadic data on its endothelium protective effects.
 Materials methods. The study was performed 70...
Introduction: Over the past decade, preeclampsia has been subject of an increased attention, as this complication is most common cause maternal mortality, triggering every third case obstetric morbidity and taking lives up to 50.000 young women worldwide each year. Despite a large number ongoing studies, no clear algorithm for monitoring pregnant with pathology developed yet.
 Materials methods: The study was conducted on 220 female Wistar rats weighing 250–300 g. In experiment,...
Михайлова 3 , Д.Б.Кузьмин 4 Комплексная оценка коррекции очищенной микронизированной флавоноидной фракцией нарушений при ADMA-подобной преэклампсии в эксперименте
Purpose: Due to the severe clinical course and high socio-economic significance of acute kidney injury, issue methods for diagnosing treating this pathology is on agenda scientific community around world. One most specific biomarkers injury KIM-1. KIM-1 an apical transmembrane protein proximal renal tubule. Elevated levels in a model ischemia-reperfusion kidneys correlate with inflammation fibrosis histological studies. The aim work was study protective effects combination peptide mimicking...
Objective. The aim of the study is to investigate correction functional disorders in ADMA-like preeclampsia with derivatives peptide imitating erythropoietin α-helix B. Materials and methods. was performed 120 white female Wistar rats weighing 250-300 g. used as experimental preeclampsia. To assess effectiveness pharmacological agents used, blood pressure, microcirculation placenta, proteinuria were recorded, content final NO metabolites plasma determined, coefficient endothelial dysfunction...
Anti-ischemic effects of high-dose cardiac cytoprotector Mexicor (0,014 g/kg/d, 0,019 g/kg/d) were examined in rabbits with experimental myocardial infarction. In addition, anti-ischemic activity (0,4 g/d) was assessed patients acute coronary syndrome (ACS). It has been demonstrated that reduced the size infarction area and decreased ratio “necrosis / ischemia area”, compared to control animals. ACS patients, facilitated faster recovery left ventricular diastolic function, also blood levels...
The aim of the study is to search compounds with neuroprotective properties among new ethylthiadiazole derivatives in simulated traumatic brain injury. Materials and methods . experiment was carried out on 78 white male rats 270±20 g line “Wistar” 5–6 months age 120 outbred sexually mature mice weighing 20±2 grams. article describes for under codes LKHT 4–15, 10–18, 11–18, 12–18 experimental injury rats. Acute toxicity studied. Pharmacological screening performed using behavioral...
Introduction: In modern medicine new pharmacotherapeutic systems significantly reducing the risk of complications are being actively searched for. The study undertaken was aimed at studying one such consisting a prosthesis coated with silver ions.
 Materials and methods: material for standard endoprostheses produced by Lintex LLC (St.-Petersburg) plastic repair anterior abdominal wall: Esfil Uniflex, as well Plasmofilter JSC system containing ions (FCS) applied to experimental samples –...
РЕЗУЛЬТАТЫ МОРФОЛОГИЧЕСКОГО ИЗУЧЕНИЯ ОСОБЕННОСТЕЙ СТРУКТУРНОЙ ОРГАНИЗАЦИИ ПЛАЦЕНТЫ КРЫСЫ НА ПОЗДНЕМ СРОКЕ ГЕСТАЦИИО.Е.Анциферова 1 , Т.И.Локтева О.В.Северинова А