A5002696942- Advanced Drug Delivery Systems
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Immunotherapy and Immune Responses
- Neuroscience and Neuropharmacology Research
- Nanoparticles: synthesis and applications
- Barrier Structure and Function Studies
- Lipid Membrane Structure and Behavior
- Neuropeptides and Animal Physiology
- Monoclonal and Polyclonal Antibodies Research
- Platelet Disorders and Treatments
- Drug Solubulity and Delivery Systems
- Drug Transport and Resistance Mechanisms
- Protease and Inhibitor Mechanisms
- Neurological Disease Mechanisms and Treatments
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Estrogen and related hormone effects
- Alzheimer's disease research and treatments
- Protein purification and stability
- Supramolecular Self-Assembly in Materials
- Nail Diseases and Treatments
- Peptidase Inhibition and Analysis
- Dendrimers and Hyperbranched Polymers
Texas Tech University Health Sciences Center
2017-2022
Texas Tech University
2017-2022
Keck Graduate Institute
2014-2021
King Saud University
2021
Indo Soviet Friendship College of Pharmacy
2013-2015
Dr. Hari Singh Gour University
2008-2014
Weatherford College
2010
The aim of the study was to prepare chemotherapeutic agent-loaded zinc oxide nanoparticles for intracellular delivery drug, better therapeutic activity. Zinc have inherent anticancer properties, hence it envisaged that by loading drug into nanoparticles, enhanced activity might be observed. were prepared using nitrate and sodium hydroxide. Starch used as stabilizing agent. characterized size, shape, entrapment efficiency, release. Further, cell line studies performed evaluate cellular uptake...
Fatty acids have been widely used as adjuvant, vehicles in drug delivery viz penetration enhancers topical and polymeric micelles to provide sustained release. However, the present investigation aims at exploring potential of fatty acid vesicles for fluconazole. Vesicles were prepared by film hydration method using oleic a principal component. Developed characterized size, size distribution, shape, vitro release, pH dependent storage stability, skin irritation study, ex-vivo permeation....
Present study aimed at exploring the potential of α-l-fucose specific, LTA (Lotus tetragonolobus from Winged or Asparagus pea) as a homing device for nanocarriers to target M cell elicitation strong immune response. grafted poly(lactic-co-glycolic acids) (PLGA) nanoparticles encapsulating hepatitis B surface antigen (HBsAg) was developed and characterized shape, size, polydispersity index, zeta potential, loading efficiency. The peyer's patch uptake studied by using confocal laser scanning...
: Fluconazole-loaded niosomes were prepared by the film hydration method with different surfactants (Span and Brij series) characterized for various parameters. Results showed that composed of Span 40, 60, 72 most stable smaller size, i.e. 0.378 ± 0.022 μm, 0.343 0.063 0.287 0.012 respectively, along higher entrapment efficiency (approx. > 41%). In vitro skin permeation retention studies suggested cutaneous accumulation was affected surfactant property vesicle size. Therefore consisting are...
This study was aimed for brain delivery of Tramadol HCl (centrally acting synthetic opioid) following intranasal administration treatment depression. Chitosan nanoparticles (NPs) were prepared by ionic gelation method followed the addition developed NPs with in Pluronic and HPMC-based mucoadhesive thermo-reversible gel. Developed formulation optimized based on various parameters such as particle size, entrapment efficiency, vitro release study. Depression induction done forced swim test...
Abstract Previous studies in our laboratory have shown that nicotine exposure decreases glucose transport across the blood–brain barrier ischemia‐reperfusion conditions. We hypothesize can also dysregulate brain parenchymal utilization by altering transporters with effects on sensitivity to ischemic stroke. In this study, we investigated of neuronal using an vitro stroke model. tested e‐Cig vaping acute slice technique. Primary cortical neurons and slices were subjected oxygen‐glucose...
The localized delivery of fluconazole (FLZ) by conventional therapy is a major impediment in achieving its therapeutic efficacy against skin infections, such as cutaneous candidiasis. Therefore, the present study was aimed to develop FLZ-loaded vesicular construct(s), liposomes and niosomes, incorporated into carbopol gel (1%; w/w) for sustained, application. niosomes were prepared lipid/nonionic surfactant-based dry-film hydration method characterized different parameters. In addition,...
Colloid science has now been reframed in advance form as nanotechnology. Novel nanoparticulate carrier systems could make an important impact on clinical practice, not only the field of targeted drug delivery but also for diagnostic agents, gene therapy and vaccine well. Polymer based nanoparticles are full numerous advantages at same time they suffer from toxicity considerations problems industrial scale up formulations. Lipid i.e. emulsions, liposomes etc. have tried to solve such related...