A5101473571- Meteorological Phenomena and Simulations
- Climate variability and models
- Cryospheric studies and observations
- Tropical and Extratropical Cyclones Research
- Precipitation Measurement and Analysis
- Climate change and permafrost
- Atmospheric and Environmental Gas Dynamics
- Wind and Air Flow Studies
- Pneumonia and Respiratory Infections
- Lipoproteins and Cardiovascular Health
- Cholesterol and Lipid Metabolism
- RNA Research and Splicing
- Berry genetics and cultivation research
- Hydrology and Drought Analysis
- Remote Sensing and Land Use
- Arctic and Antarctic ice dynamics
- Lysosomal Storage Disorders Research
- Influenza Virus Research Studies
- Advanced Statistical Methods and Models
- Geophysics and Gravity Measurements
- Genetic Associations and Epidemiology
- Berberine and alkaloids research
- Cancer, Lipids, and Metabolism
- Forest, Soil, and Plant Ecology in China
- Pancreatic and Hepatic Oncology Research
Tianjin Research Institute of Water Transport Engineering
2013-2020
Weatherford College
2020
Ionic Systems (United States)
2017-2019
Panasonic (United States)
2017-2019
Water & Earth Technologie (United States)
2019
Capital Normal University
2006-2018
University of Chinese Academy of Sciences
2016
National Time Service Center
2016
Chinese Academy of Sciences
2016
Xi'an University of Science and Technology
2016
HMGCR(3-Hydroxy-3-methylglutaryl coenzyme A reductase), the direct target of statin inhibition, undergoes alternative splicing exon 13, which encodes part statin-binding domain enzyme. We hypothesized that HMGCR might be related to interindividual variation in plasma low-density lipoprotein cholesterol response treatment.We measured mRNA expression both full-length and alternatively spliced transcript lacking 13 (HMGCRv_1) 170 simvastatin-incubated immortalized lymphocyte cell lines derived...
Diurnal variations in the formation and development of convective storms over contiguous North China during warm season were studied using reflectivity from six Next Generation Weather Radars between 2008 2011. Our results, including temporal spatial analysis hourly storm frequency through season, inter‐month comparisons June, July August, indicate that most initiate northwestern mountains afternoon as a result solar heating, with highest lowest August. Storms propagate to southeastern...
Genes involved in cholesterol biosynthesis and uptake are transcriptionally regulated response to cellular sterol content a coordinated manner. A number of these genes, including 3-hydroxy-3-methylglutaryl coenzyme reductase (HMGCR) LDL receptor (LDLR), undergo alternative splicing, resulting reductions enzyme or protein activity. Here we demonstrate that depletion suppresses, loading induces, splicing multiple genes the maintenance homeostasis HMGCR LDLR, key regulators uptake,...
The diurnal evolution and distribution of warm-season convective storms in different prevailing wind regimes at the 925 hPa 500 levels over contiguous North China have been studied using a climatology based on radar reflectivity mosaics, soundings, reanalysis data from 15 May to September, 2008–2011. In level, frequency occurrence convection is highest for south-southwesterly flows, followed by that south-southeasterly flows. low-level southerly warm moist flow foothills plains favors...
Abstract The Geostationary Operational Environmental Satellite (GOES) imager data could provide a continuous image of the evolutionary pattern severe weather phenomena with its high spatial and temporal resolution. capability to assimilate GOES radiances has been developed within Weather Research Forecasting model's assimilation system. Compared benchmark experiment no data, impact assimilating on analysis forecast convective process over Mexico in 7–10 March 2016 was assessed through...
A common synonymous single nucleotide polymorphism in exon 12 of the low-density lipoprotein receptor (LDLR) gene, rs688, has been associated with increased plasma total and LDL cholesterol several populations. Using immortalized lymphoblastoid cell lines from a healthy study population, we confirmed an earlier report that minor allele rs688 is alternative splicing (P < 0.05) showed this triggered nonsense-mediated decay (NMD) alternatively spliced LDLR mRNA. However, since polymorphisms may...
Abstract Tropospheric Airborne Meteorological Data Reporting (TAMDAR) observations are becoming a major data source for numerical weather prediction (NWP) because of the advantages their high spatiotemporal resolution and humidity measurements. In this study, estimation TAMDAR observational errors, impacts with new error statistics on short-term forecasts presented. The errors estimated by three-way collocated statistical comparison. This method employs meteorological reports from three...
This article presents a new methodology for assimilating wind observations in their observed form of speed and direction, while taking into account both direction error. It ensures the analysed will be consistent with background values. The formulation is implemented Weather Research Forecasting Data Assimilation system, idealised experiments are used to demonstrate potential benefit. results suggest that analyses from more reasonable when compared conventional methodology. forecasts...
Evidence is limited concerning the association between serum concentrations of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (APO A-I) severe acute pancreatitis (SAP). This study was designed to explore whether HDL-C APO were independently correlated SAP after adjusting for covariates.There 1127 patients with who recruited from a tertiary teaching hospital in Wenzhou 1 January 2018 30 April 2020. The independent variables baseline levels HDL-C, collected within 24 h...
The assimilation of wind observations in the form speed and direction (asm_sd) by Weather Research Forecasting Model Data Assimilation System (WRFDA) was performed using real data employing a series cycling experiments for 2-week period, as follow-up an idealised post hoc experiment. satellite-derived Atmospheric Motion Vectors (AMV) surface dataset Meteorological Ingest (MADIS) were assimilated. This new method takes into account observation errors both (<em>spd</em>) (<em>dir</em>), WRFDA...
TMEM55B (transmembrane protein 55B) is a phosphatidylinositol-(4,5)-bisphosphate (PI[4,5]P2) phosphatase that regulates cellular cholesterol, modulates LDLR (low-density lipoprotein receptor) decay, and lysosome function. We tested the effects of Tmem55b knockdown on plasma lipids in mice assessed roles lysosomal degradation change mediating these effects. Approach Results: Western diet-fed C57BL/6J were treated with antisense oligonucleotides against or nontargeting control for 3 to 4...
This study evaluates the impact of Tropospheric Airborne Meteorological Data Reporting (TAMDAR) observations on regional 24-hour forecast error reduction over Continental United States (CONUS) domain using adjoint-based sensitivity to observation (FSO) method as diagnostic tool. The relative TAMDAR reducing was assessed by conducting WRFDA FSO experiments for two two-week-long periods, one in January and June 2010. These assimilated operational data other conventional observations, well GPS...
Climate extremes are changing at mid–high latitudes due to the effects of climate change. We defined duration surface icing (ice formation on open water) in north China from 1961 2015, along with its annual start and end date, based daily measurements by observers 346 weather stations. A comprehensive analysis temporal spatial variations these data showed that regional mean has a high correlation coefficient 0.97 number frost days (calculated minimum temperature below 0 °C), some...
Abstract A variational bias correction (VarBC) scheme is developed and tested using regional Weather Research Forecasting Model Data Assimilation (WRFDA) to correct systematic errors in aircraft-based measurements of temperature produced by the Tropospheric Airborne Meteorological Reporting (TAMDAR) system. Various models were investigated, one or all aircraft height tendency, Mach number, observed as predictors. These variables expected account for representation some well-known error...
Development and application of passive microwave remote sensing indexes,such as polarization index,scattering index soil moisture are summarized in this paper.The values difference index,ΔT_(37) ratio index,MPDI five sites the Central Tibetan Plateau obtained analysed from observed data during 1998 IOP,including data(TMI data) in-situ data.Results show that:(i) averaged ΔT_(37) ANDUO MS3608 about 15 K which characteristics bare soil;(ii) MPDI at change less with time,and it means that...