About
Contact & Profiles
A5024972521
Research Areas
- Sphingolipid Metabolism and Signaling
- Pregnancy and preeclampsia studies
- Pregnancy-related medical research
- Synthesis of Tetrazole Derivatives
- Reproductive System and Pregnancy
Women and Children’s Health Research Institute
2021-2022
University of Alberta
2021-2022
Preeclampsia (PE) involves inadequate placental function. This can occur due to elevated pro-inflammatory tumor necrosis factor-α (TNF-α). In other tissues, TNF-α signals via sphingosine kinase 1 (SphK1). SphK1 hinders syncytial formation. Whether this occurs downstream of signaling is unclear. We hypothesized that levels are higher in PE and decreases function, increases shedding, cytokine/factor release activity. Term biopsies were analyzed for using immunofluorescence qRT-PCR. explants...
10.3390/ijms23073750
article
EN
International Journal of Molecular Sciences
2022-03-29
10.1016/j.placenta.2021.07.166
article
EN
Placenta
2021-08-26
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