A5040326072- Bone Tissue Engineering Materials
- 3D Printing in Biomedical Research
- Cellular Mechanics and Interactions
- Graphene and Nanomaterials Applications
- Genetic Neurodegenerative Diseases
- Neurological disorders and treatments
- Tissue Engineering and Regenerative Medicine
- Neuroscience and Neuropharmacology Research
- Innovative Microfluidic and Catalytic Techniques Innovation
- Hydrogels: synthesis, properties, applications
- Nanoplatforms for cancer theranostics
- Pluripotent Stem Cells Research
- Oral and Maxillofacial Pathology
- Neuroscience and Neural Engineering
- Electrospun Nanofibers in Biomedical Applications
- Endodontics and Root Canal Treatments
- Biosensors and Analytical Detection
- Erosion and Abrasive Machining
University of Ottawa
2020-2024
Carleton University
2020-2023
Institute for Biomedical Engineering
2021
Modern in vitro technologies for preclinical research, including organ-on-a-chip, organoids- and assembloid-based systems, have rapidly emerged as pivotal tools elucidating disease mechanisms assessing the efficacy of putative therapeutics. In this context, advanced models Parkinson's Disease (PD) offer potential to accelerate drug discovery by enabling effective platforms that recapitulate both physiological pathological attributes vivo environment. Although these systems often aim at...
Neuronal disorders are characterized by the loss of functional neurons and disrupted neuroanatomical connectivity, severely impacting quality life patients. This study investigates a novel electroconductive nanocomposite consisting glycine-derived carbon nanodots (GlyCNDs) incorporated into collagen matrix validates its beneficial physicochemical electro-active cueing to relevant cells. To this end, work employs mouse induced pluripotent stem cell (iPSC)-derived neural progenitor (NP)...
Poly(vinyl chloride) (PVC) is the most used biomedical polymer worldwide. PVC a stable and chemically inert polymer. However, microorganisms can colonize producing device-associated infections. While surface modifications of help improve antimicrobial antiviral properties, nature makes those challenging potentially toxic. In this work, we modified using derivative riboflavin molecule that was tethered to plasma-treated surface. Upon low dosage blue light, became photochemically activated,...
In this study, micro-engineered chitosan substrates were employed to investigate the compounded effects of topography, roughness and stiffness on response DRGs hMSCs.
Neural Progenitor Spheroids In article 2301894, Fabio Variola and co-workers show a novel electroconductive nanocomposite consisting of collagen matrix decorated with carbon nanodots supports neurite outgrowth, directs neurogenesis without exogenous factors elicits the electrophysiological maturation neural progenitor spheroids.
In recent years there has been ample interest in nanoscale modifications of synthetic biomaterials to understand fundamental aspects cell-surface interactions towards improved biological outcomes. this study, we aimed at closing on the effects nanotubular TiO