A5069131721- Inflammatory Bowel Disease
- Microscopic Colitis
- Helicobacter pylori-related gastroenterology studies
- Eosinophilic Esophagitis
- Gastroesophageal reflux and treatments
- Parvovirus B19 Infection Studies
- Esophageal and GI Pathology
- COVID-19 and healthcare impacts
- Immunodeficiency and Autoimmune Disorders
- Glycogen Storage Diseases and Myoclonus
- Healthcare and Venom Research
- Carbohydrate Chemistry and Synthesis
- Anesthesia and Sedative Agents
- Infant Nutrition and Health
- Intensive Care Unit Cognitive Disorders
- Liver Disease Diagnosis and Treatment
- Infant Health and Development
- Drug-Induced Hepatotoxicity and Protection
- Colorectal Cancer Screening and Detection
- Gastrointestinal motility and disorders
- Bee Products Chemical Analysis
- Genetic factors in colorectal cancer
- Autoimmune and Inflammatory Disorders
- Genetics and Neurodevelopmental Disorders
- Airway Management and Intubation Techniques
Keimyung University
2012-2025
Keimyung University Dongsan Medical Center
2018-2024
Seoul National University
2014-2019
Inflammatory bowel disease (IBD) is a heterogeneous chronic of unknown etiology. Although it an important that shows rapid increase in pediatric population, there are no studies represent specific region Korea. Therefore, we studied the epidemiological and phenotypic characteristics IBD Daegu-Kyungpook province, Korea.We included 122 children with initially diagnosed at one four university hospitals province between July 2010 June 2016. We investigated incidence trends, clinical diagnosis...
Although antinuclear antibody (ANA) is frequently observed in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), its clinical significance children remains unclear and controversial. In this study, we investigated the prevalence of ANA positivity factors associated it pediatric MASLD without concurrent autoimmune hepatitis. We retrospectively reviewed medical records aged 4-18 years diagnosed tested for from January 2015 to December 2020 at 10 hospitals Korea....
Background: Glycogen storage disease (GSD) is an inherited disorder leading to abnormal glucose metabolism and glycogen accumulation, associated with various complications including hepatic adenoma hepatocellular carcinoma.The aim of this study was analyze the risk factors for its malignant change, carcinoma-free survival rate in patients GSD who developed adenoma.Methods: A total 72 were enrolled from March 1982 September 2013 at Seoul National University Children's Hospital retrospectively...
Background and Aim: There is paucity of data regarding the epidemiology pediatric IBD in Asia compared to that Western countries. We aimed investigate incidence prevalence trends inflammatory bowel disease (IBD) Daegu-Kyungpook province South Korea from 2017 2020. Methods: This study was a multicenter, retrospective conducted eight referral centers located province. Children adolescents ≤18 years who were initially diagnosed with between 2020 included. The annual number children newly...
We aimed to investigate the disease phenotype of Korean pediatric Crohn's (CD) patients at diagnosis according Paris classification by comparison with from European multicenter 5-years recruitment children newly developed IBD (EUROKIDS registry).Korean and adolescents who had been diagnosed CD age <18 years during 2013-2016 were included in this retrospective study. Disease was classified classification, compared published data EUROKIDS study.A total 255 included. The median 14.7 (range,...
Hepatocyte apoptosis and inflammation play important roles in cholestatic liver diseases. Bee venom-derived secretory phospholipase A2 (bvPLA2) has been shown to ameliorate various inflammatory However, whether bvPLA2 a therapeutic effect against disease not evaluated. Therefore, we investigated the effects of on injury fibrosis murine model 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) diet feeding. The administration ameliorated damage, cholestasis, DDC diet-fed mice, as assessed by...
The aim of the study was to identify factors related recurrence intussusception in pediatric patients.The medical charts patients diagnosed with and treated at Dongsan Medical Center, between March 2015 June 2017, were retrospectively reviewed. Univariate multivariate analyses performed.Among 137 patients, 23 (16.8%) had a recurrent 8 these (6%) more than 2 episodes recurrence. age diagnosis significantly different non-recurrence group (p=0.026), >1 year time associated greater rate...
We investigated fecal calprotectin (FC) levels in preterm infants with and without feeding intolerance (FI), compared the FC according to type of feeding.The medical records 67 premature were reviewed retrospectively. The fully enteral-fed classified into two groups; FI group (29 infants) control (31 infants). Seven necrotizing enterocolitis, sepsis, perinatal asphyxia excluded. If breast milk (BM) or formula (PF) could not be tolerated by FI, amino acid-based (AAF) was tried temporarily....
Background: This study aimed to investigate the awareness and application of ROME IV criteria for functional constipation (FC) in real-world practices assessed differences between pediatric gastroenterologists (PGs) general pediatricians.Methods: A total 239 (47.8%) out 500 nationwide pediatricians answered a questionnaire diagnosis management FC; 60 were PGs (75% Korea).Results: 16.6% aware exact criteria.Perianal examination digital rectal practiced less, with higher tendency among (P <...
The effects of probiotics in children vary based on diseases and probiotic strains. We aim to investigate the effectiveness Saccharomyces boulardii lactulose for treating childhood functional constipation.This open-label randomized controlled trial was conducted at 10 university hospitals Korea. Children who were diagnosed with constipation allocated 3 groups (lactulose monotherapy, combination therapy, S. monotherapy). primary outcome treatment success rate that accordingly defined as ≥...
Favourable clinical data were published on the efficacy of CT-P13, first biosimilar infliximab (IFX), in pediatric inflammatory bowel disease (IBD); however, few studies have compared effect endoscopic healing (EH) and drug retention rate between IFX originator CT-P13. Therefore, we aimed to compare EH Children with Crohn's (CD) ulcerative colitis (UC)/IBD-unclassified (IBD-U) at 22 medical centers enrolled, a retrospective review conducted 1-year last follow-up. Clinical remission,...
Few studies on gastric tube interposition for esophageal reconstruction in children have assessed the long-term outcomes and quality of life (QoL). The aim this study is to evaluate QoL after a by reviewing our experiences with reconstruction.Twenty-six patients were included who underwent from 1996 2011 at institution. We reviewed medical records conducted telephone surveys, prospectively performed esophagography, endoscopy, 24-hour pH monitoring, manometry. median follow-up period 12...
Pathologic aerophagia (PA) may lead to bowel perforation or volvulus in mentally retarded patients. The authors investigated the effects of clonazepam on management PA children with severe profound mental retardation (MR).This study was undertaken as a retrospective case analysis 21 patients MR who were followed for over 12 months and diagnosed having PA. Patients assigned two groups, that is, randomized open-labeled, treatment group reassurance group. following recorded analyzed; age,...
We investigated whether the severity of anxiety among children undergoing endoscopy could affect sedation. prospectively recruited patients under 18 years age who were scheduled to undergo esophagogastroduodenoscopy (EGD). Baseline was evaluated using Spence Children's Anxiety Scale (SCAS). Our analysis considered type and dose sedative drugs, degree sedation, complications associated with sedation according scale score. The mean total SCAS T-scores each subscale score significantly higher...
Glycogen storage disease (GSD) IV is a rare autosomal recessive inherited disorder caused by mutations in the gene coding for glycogen branching enzyme leading to progressive liver disease. GSD associated with GBE1, which encodes enzyme. We report case of homozygous GBE1 (c.791G>A (p.Gly264Glu), was successfully treated transplantation.
Sedative upper endoscopy is similar in pediatrics and adults, but it characteristically more likely to lead respiratory failure. Although recommended guidelines for pediatric procedural sedation are available within South Korea internationally, Korean endoscopists use different drugs, either alone or combination, practice. Efforts being made minimize the risk of while avoiding challenges. The purpose this study was collect analyze data on methods used by help physicians perform sedative...
There are limited data regarding the extraintestinal manifestations (EIMs) associated with pediatric inflammatory bowel disease (IBD) in Korea. We aimed to investigate clinical features and factors development of EIMs Korean children adolescents IBD.This multicenter, retrospective study was conducted from 2010 2017. Baseline clinicodemographic, laboratory findings, activity, phenotypes, were investigated.A total 172 patients included. One-hundred thirty-seven (79.7%) had Crohn's (CD), 35...
It is uncertain whether non-alcoholic fatty liver disease (NAFLD) associated with subclinical hypothyroidism (SH) in pediatric patients. The purpose of this study was to investigated the prevalence and related factors SH patients NAFLD. We also evaluate association between fibrosis SH.We retrospectively reviewed medical records for aged 4 18 years who were diagnosed NAFLD tested thyroid function from January 2015 December 2019 at 10 hospitals Korea.The included 428 13.6%. In multivariate...
Cytomegalovirus (CMV)-associated esophageal ulcer is rare in immunocompetent infants. The presence of inclusion bodies and immunohistochemical staining for CMV biopsy specimens obtained during esophagogastroduodenoscopy (EGD) indicate that such ulcers occur because infection. A 7-week-old female infant who experienced frequent vomiting feeding intolerance was diagnosed with a massive CMV-associated the distal esophagus. improved after conservative treatment using proton-pump inhibitors;...
Eating disorders often result in somatic complications, including cardiac abnormalities. Cardiac abnormalities may involve any part of the heart, conduction system, and can lead to sudden death. The current study aimed evaluate incidence complications pediatric patients with eating their associated factors.We retrospectively analyzed aged 10-18 years who were diagnosed DSM-V (Diagnostic Statistical Manual Mental Disorder-V) underwent electrocardiography (ECG) and/or echocardiography between...
In East Asian countries, there are only a few epidemiologic studies of eosinophilic esophagitis (EoE) and no in children. We investigated the incidence compared clinical characteristics EoE gastroenteritis involving esophagus (EGEIE) Korean children.A total 910 children, who had symptoms esophageal dysfunction, from 10 hospitals Korea were included. was diagnosed according to diagnostic guidelines EGEIE when >15 eosinophils per high power field (HPF) >20 HPF deposited stomach duodenum with...
: Although mucosal healing (MH) is acknowledged as the treatment target in treat-to-target era, there are limitations on repeated endoscopic examinations, especially pediatric patients. We aimed to investigate whether fecal calprotectin (FC) could serve a surrogate marker for assessment of MH patients with Crohn's disease (CD) who have achieved sustained clinical remission (CR) while treated anti-tumor necrosis factor (TNF) agents.This multicenter retrospective cross-sectional study included...