A5012649421- Medication Adherence and Compliance
- Forensic Toxicology and Drug Analysis
- Biosimilars and Bioanalytical Methods
- Erythropoietin and Anemia Treatment
- Pharmaceutical and Antibiotic Environmental Impacts
- Pharmacological Effects and Toxicity Studies
- Chronic Lymphocytic Leukemia Research
- Hormonal and reproductive studies
- Statistical Methods in Clinical Trials
- Epilepsy research and treatment
- Cancer Treatment and Pharmacology
- Bipolar Disorder and Treatment
- Biosensors and Analytical Detection
- Cell Image Analysis Techniques
- Poisoning and overdose treatments
- Biomedical and Engineering Education
- Heavy Metal Exposure and Toxicity
- Analytical Methods in Pharmaceuticals
- Drug-Induced Hepatotoxicity and Protection
- Sodium Intake and Health
- Advanced Breast Cancer Therapies
- Innovative Microfluidic and Catalytic Techniques Innovation
- Analytical chemistry methods development
- Neurotransmitter Receptor Influence on Behavior
- Consumer Attitudes and Food Labeling
Saarland University
2019-2024
Abstract Volumetric absorptive microsampling (VAMS), an emerging technique, is expected to overcome some disadvantages of dried blood spots such as volume inaccuracy and influence hematocrit (HT). This study aimed develop evaluate a VAMS-based strategy for quantification 13 frequently prescribed antipsychotics in finger prick within the scope adherence monitoring complement already-established qualitative urine analysis. The final workflow consisted VAMS tip hydration subsequent...
Background It is currently unknown if antihypertensive drugs can be monitored in oral fluid (OF) using liquid chromatography coupled to high-resolution mass spectrometry. Methods and Results We assessed adherence spectrometry OF, plasma, urine of 56 consecutive patients with hypertension referred a tertiary unit. Of these patients, 59% were completely adherent (all detectable urine), whereas 29% 13% partially (1 drug not urine) or nonadherent (>1 respectively. Adherent on fewer (P=0.001),...
Oral endocrine therapies (OET) for breast cancer treatment need to be taken over a long period of time and are associated with considerable side effects. Therefore, adherence OET is an important issue high clinical significance patients' caregivers. We hypothesized that new bioanalytical strategy based on liquid chromatography high-resolution mass spectrometry might suitable unbiased monitoring (AM) OET. Four different biomatrices (plasma, urine, finger prick blood by volumetric absorptive...
As part of the European Bioanalysis Forum's continued commitment to develop young scientists beyond their scientific skills, we also focus on soft skills and a community responsibility during Young Scientist Symposia, with Science Café. In previous years, have focused topics such as sustainability (green lab) or impact COVID-19 pandemic career development. At ninth Symposium, Café roundtables work-life balance how caring for it can be beneficial both individual company. Feedback from...
Wastewater (WW)-based epidemiology is an approach for the objective surveillance of consumption (illicit) drugs in populations. The aims this study were to monitor abuse, cognitive enhancers, and their metabolites as biomarkers influent WW. Data obtained from different sampling points mean daily loads compared with previously published data. prevalence analytes was monitored WW grab samples collected monthly over 22 months at two 24 h composite 2 weeks a treatment plant same city....
Background: Analytical monitoring of adherence using mass spectrometry (MS) plays an important role in clinical toxicology. Unambiguous detection drugs (of abuse) and/or their metabolites body fluids is needed to monitor intake medication as prescribed or abstinence a follow-up detoxification procedures. This study focused on the advantages and disadvantages different sample matrices used for MS-based monitoring. Methods: Relevant articles were identified through literature search PubMed...
Volumetric absorptive microsampling (VAMS), an emerging technique, is a promising tool for adherence monitoring. This study focused on development of analytical methodology to improve VAMS-based strategies assessment by analyzing angiotensin-converting-enzyme (ACE) inhibitors, loop diuretics, potassium-sparing diuretic, and thiazide diuretic. Development included sample preparation, chromatographic conditions, mass spectrometry settings, validation, demonstrating proof concept....
Sewage-based epidemiology using influent wastewater is used to estimate the consumption trends of (illicit) drugs over a short or long period time in subpopulation. The current study aimed develop two separate methods for quantitative analysis selected abuse (DOA) and cognitive enhancers reversed-phase (RP) hydrophilic interaction liquid chromatography (HILIC) coupled high-resolution tandem mass spectrometry (LC-HRMS/MS). performance RP HILIC column was evaluated. A simple solid phase...
Chloroquine, a drug approved for the treatment of malaria, is frequently used to commit suicide. We report about suicide attempt by ingesting high dose chloroquine in combination with other drugs. Findings emergency toxicology screening blood and urine those follow-up analyses are discussed. Systematic toxicological analysis approaches revealed presence chloroquine, butylscopolamine, cafedrine, diazepam, lorazepam, metoclopramide, nordazepam, norephedrine...
After 2 years of COVID-19 restrictions, the 8th Young Scientist Symposium was organized again as a face-to-face meeting covering broad array scientific presentations. As in previous editions, by young scientists for under umbrella European Bioanalysis Forum and collaboration with academia. The traditional Science Café included an interactive round table session. This year, main focus on challenges communication. New edition session connecting more seasoned experts effort to bridge talent...
Objective Dietary sodium intake represents a risk factor for cardiovascular disease and mortality. The study sought to analyse the content of effervescent dietary supplements drugs in Germany USA. Design Comparative cross-sectional study. Setting methods 39 supplement tablets available was measured May June 2022 using optical emission spectrometry with inductively coupled argon plasma. 33 common pharmacy-only (over-the-counter (OTC) drugs) obtained from summary product characteristics. We...
The active, poisonous constituents in Taxus baccata, the yew plants, are taxine alkaloids whose main action is suggested to be a block of calcium and sodium channels. B (30%) A (1.3%). Symptoms can include bradycardia, bradypnea, diastolic, cardiac standstill. current investigation reports analytical toxicology human blood urine confirm suspected ingestion needles. This includes qualitative detection several ingredients, including alkaloids, validated quantification 3,5-dimethoxyphenol,...