Sarah J. N. Duxbury

ORCID: 0000-0003-1514-8617
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About
Contact & Profiles
Research Areas
  • Biocrusts and Microbial Ecology
  • Evolution and Genetic Dynamics
  • Aquatic Ecosystems and Phytoplankton Dynamics
  • Photosynthetic Processes and Mechanisms
  • Gut microbiota and health
  • Antifungal resistance and susceptibility
  • Pharmaceutical and Antibiotic Environmental Impacts
  • Antibiotic Resistance in Bacteria
  • Pharmacogenetics and Drug Metabolism
  • Plant Pathogens and Fungal Diseases
  • Fungal Biology and Applications
  • Genomics and Phylogenetic Studies
  • Ecosystem dynamics and resilience
  • Tracheal and airway disorders
  • Entomopathogenic Microorganisms in Pest Control
  • Esophageal and GI Pathology
  • Fecal contamination and water quality
  • Salmonella and Campylobacter epidemiology
  • Microbial Community Ecology and Physiology
  • Antibiotics Pharmacokinetics and Efficacy
  • RNA and protein synthesis mechanisms
  • Coagulation and Flocculation Studies
  • Dysphagia Assessment and Management
  • Bacteriophages and microbial interactions
  • Groundwater flow and contamination studies

University of Warwick
2022-2024

Wageningen University & Research
2020-2022

University College Cork
2021

University of Exeter
2017-2020

Plasmids are important vectors for the spread of genes among diverse populations bacteria. However, there is no standard method to determine rate at which they horizontally via conjugation. Here, we compare commonly used methods on simulated and experimental data, show that resulting conjugation estimates often depend strongly time measurement, initial population densities, or ratio donor recipient populations. Differences in growth rate, e.g. induced by sub-lethal antibiotic concentrations...

10.1016/j.plasmid.2022.102627 article EN cc-by-nc-nd Plasmid 2022-03-07

Candida species are common human fungal pathogens causing a wide range of clinical diseases, ranging from superficial infections to life-threatening systemic disease. Superficial include...

10.1080/21505594.2017.1347744 article EN Virulence 2017-06-28

This protocol describes the culturing and long-term preservation of cyanobacterial communities from environmental Samples.

10.17504/protocols.io.6qpvr97qzvmk/v1 preprint EN 2025-01-09

ABSTRACT Understanding how microbial communities maintain stable compositional diversity is key for predicting community function. Studies from species pairwise interactions and synthetic indicate that metabolic spatial organisation can influence coexistence, but the relevance of these factors in more complex unclear. Model systems often lack multi-species complexity, thereby making it difficult to study temporally. Here we used a spatially-organised cyanobacterial enrichment investigate its...

10.1101/2022.12.13.520286 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2022-12-13

Abstract Cyanobacteria are key contributors to biogeochemical cycles through photosynthesis and carbon fixation. In filamentous, multicellular cyanobacteria these functions can be influenced gliding motility, which enables filaments localise in response light also form aggregates. Here, we use the aggregate forming species Fluctiforma draycotensis study motility dynamics detail. We find that move curved straight trajectories interspersed with re-orientation or reversal of direction. Most...

10.1101/2024.02.06.579126 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2024-02-06

Cyanobacteria are key contributors to biogeochemical cycles through photosynthesis and carbon fixation. In filamentous, multicellular cyanobacteria these functions can be influenced gliding motility, which enables filaments localise in response light also form aggregates. Here, we use the aggregate forming species Fluctiforma draycotensis study motility dynamics detail. We find that move curved straight trajectories interspersed with re-orientation or reversal of direction. Most reversals...

10.7554/elife.100768 preprint EN 2024-09-26

Cyanobacteria are key contributors to biogeochemical cycles through photosynthesis and carbon fixation. In filamentous, multicellular cyanobacteria these functions can be influenced gliding motility, which enables filaments localise in response light also form aggregates. Here, we use the aggregate forming species Fluctiforma draycotensis study motility dynamics detail. We find that move curved straight trajectories interspersed with re-orientation or reversal of direction. Most reversals...

10.7554/elife.100768.1 preprint EN 2024-09-26

Antimicrobial resistance frequently carries a fitness cost to pathogen, measured as reduction in growth rate compared the sensitive wild-type, absence of antibiotics. Existing empirical evidence points following relationship between and virulence. If resistant pathogen suffers terms reduced it commonly has lower virulence wild-type. this is absent so Here we show, using experimental evolution drug fungal human Candida glabrata, that strains need not result Phenotypically heterogeneous...

10.1098/rspb.2020.0761 article EN Proceedings of the Royal Society B Biological Sciences 2020-07-14

Plasmid-mediated antimicrobial resistance is a major contributor to the spread of genes within bacterial communities. Successful plasmid depends upon balance between fitness effects on host and rates horizontal transmission. While these key parameters are readily quantified in vitro , influence interactions with other microbiome members largely unknown. Here, we investigated three genera lactic acid bacteria (LAB) derived from chicken gastrointestinal an epidemic narrow-range ESBL plasmid,...

10.1098/rspb.2021.2027 article EN cc-by Proceedings of the Royal Society B Biological Sciences 2021-11-03

Abstract Plasmids are important vectors for the spread of genes among diverse populations bacteria. However, there is no standard method to determine rate at which they horizontally via conjugation. Here, we compare commonly used methods on simulated and experimental data, show that resulting conjugation estimates often depend strongly time measurement, initial population densities, or ratio donor recipient populations. Differences in growth rate, e.g. induced by sub-lethal antibiotic...

10.1101/2020.03.09.980862 preprint EN cc-by-nc-nd bioRxiv (Cold Spring Harbor Laboratory) 2020-03-09

BACKGROUND: Interprofessional education (IPE) is considered to be a necessary step in preparing the healthcare workforce for collaborative patient care. Dysphagia, complex health condition, requires collaboration between disciplines such as medicine (MED) and speech language therapy (SLT). Therefore, both must have shared understanding of dysphagia management within context interprofessional OBJECTIVE: This study investigated MED SLT students’ learning about following an IPE workshop. The...

10.3233/acs-210027 article EN Advances in Communication and Swallowing 2021-09-24

Antimicrobial resistance frequently carries a fitness cost to pathogen, measured as reduction in growth rate compared the sensitive wild type, absence of antibiotics. Existing empirical evidence points following relationship between and virulence. If resistant pathogen suffers terms reduced it commonly has lower virulence type. this is absent so Here we show, using experimental evolution drug fungal human Candida glabrata, that strains need not result Phenotypically heterogeneous populations...

10.6084/m9.figshare.c.5044115.v1 article EN 2020-06-30
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