A5080060643- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Chronic Myeloid Leukemia Treatments
- Hematopoietic Stem Cell Transplantation
- Childhood Cancer Survivors' Quality of Life
- Blood disorders and treatments
- Neuroblastoma Research and Treatments
- Immunodeficiency and Autoimmune Disorders
- Cancer therapeutics and mechanisms
- CAR-T cell therapy research
- Erythrocyte Function and Pathophysiology
- T-cell and Retrovirus Studies
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Traumatic Brain Injury Research
- Viral Infectious Diseases and Gene Expression in Insects
- Neutropenia and Cancer Infections
- Chronic Lymphocytic Leukemia Research
- Histiocytic Disorders and Treatments
- Glycogen Storage Diseases and Myoclonus
- Parvovirus B19 Infection Studies
- Endometrial and Cervical Cancer Treatments
- Galectins and Cancer Biology
- Complement system in diseases
- Spinal Hematomas and Complications
Kyoto Prefectural University of Medicine
2015-2025
National Center For Child Health and Development
2022
Kyoto City Hospital
2008-2017
Akashi Municipal City Hospital
2006-2008
Pediatrics and Genetics
2007
Chiba Cancer Center
2005
Purpose MYCN amplification (MNA) indicates a poor prognosis in neuroblastoma (NB) and is routinely assayed for therapy stratification. We aimed to develop diagnostic tool predict status using serum DNA, which, cancer patients, predominantly originates from tumor-released DNA. Patients Methods Using DNA-based real-time quantitative polymerase chain reaction, we simultaneously quantified (2p24) reference gene, NAGK (2p12), evaluated copy number as an MYCN/NAGK (M/N) ratio 87 NB patients whose...
Phosphoglycerate kinase 1 (PGK-1) is a glycolytic enzyme encoded by PGK-1, which maps to the X chromosome. PGK-1 deficiency causes X-linked recessive hereditary chronic hemolytic anemia, myopathy, and neurological disorders due insufficient ATP regeneration. Early-onset parkinsonism has occasionally been reported as complication of this condition. However, heterozygous carriers were thought be neurologically asymptomatic. Here, we report boy with his mother, carrier mutation in both whom...
Fenretinide, which mediates apoptosis in neuroblastoma cells, is being considered as a novel therapeutic for neuroblastoma. The cytotoxic mechanisms of fenretinide, however, have not been fully elucidated. Sustained-activation JNK and p38 MAPK signaling has shown recently to pivotal role stress-induced apoptosis. Whether fenretinide activates the cells known. In present study, induced sustained-activation both cells. Pretreatment with antioxidant L-ascorbic acid almost completely inhibited...
Abstract Recently, it has been reported that Crohn's‐like intractable colitis occurred in approximately 20% of the patients with XIAP deficiency, also known as X‐linked lymphoproliferative disease type 2. Because treatment used for Crohn's is not always effective related to more should be established. Although several studies allo‐ HSCT might promising even outcome using MAC deficiency extremely poor due frequent TRM. In addition, there little information about allo‐HSCT deficiency. Herein,...
Abstract Purpose: Malignant rhabdoid tumor (MRT) is a rare and highly aggressive neoplasm of young children. Current treatments have had only limited success. Epidermal growth factor receptor (EGFR) was found recently to be expressed on MRT cell lines. Gefitinib (trade name Iressa) an oral selective EGFR-tyrosine kinase inhibitor has been demonstrated effective in inhibiting the proliferation cancer cells vivo as well clinical trials. This encouraged us examine antitumor effects gefitinib...
Early T-cell precursor-acute lymphoblastic leukemia (ETP-ALL) has been identified as a high-risk subtype of pediatric acute (T-ALL). Conventional chemotherapy is not fully effective for this leukemia; therefore, potential therapeutic targets need to be explored. Analysis the gene expression patterns transcription factors in T-ALL revealed that MEF2C and FLT3 were expressed at higher levels ETP-ALL than typical T-ALL. Using human BaF3 cell lines with high MEF2C, present study tested whether...
We report the first case of a tumor Ewing sarcoma family tumors arising from urinary bladder 3 years after chemotherapy for acute lymphoblastic leukemia. A 16-year-old boy complained macrohematuria and dysuria during posttreatment follow up his Ultrasonography computed tomography revealed 1-cm sized intravesical tumor. The was transurethrally resected with no residual at margin. Histopathologic analyses small round blue cell positive staining CD99MIC2 antibody. EWS-FLI1 fusion transcripts...
HSCT-associated thrombotic microangiopathy (TA-TMA) is a severe complication with poor prognosis. Recently, it has been reported that complement system dysregulation, such as CFH autoantibodies and deletions CFH-related genes 3 1, induced TA-TMA. In addition, C4d-positive renal arterioles are both good marker of activation useful diagnostic tool for Because dysregulation the associated TA-TMA, might be therapeutic target, eculizumab, terminal inhibitor. Herein, we describe an eight-yr-old...
Abstract Background L‐asparaginase (L‐Asp)‐associated thromboembolisms are serious complications in pediatrics patients with acute lymphoblastic leukemia (ALL), especially at ≥10.0 years old, but the pathogenesis remains to be clarified. Procedure We conducted a multicenter, prospective study of 72 ALL aged 1.0 15.2 treated either Berlin‐Frankfurt‐Münster (BFM) 95‐ALL oriented regimen or Japan Association Childhood Leukemia Study ALL‐02 protocol. divided into each treatment protocol and...
Conventional conditioning regimens for children with lymphoid malignancy undergoing allogeneic hematopoietic cell transplantation (HCT) are myeloablative and involve high-dose total body irradiation (TBI). Such associated significant late complications.
A 20-year-old female developed a relapse of B-precursor acute lymphoblastic leukemia (ALL) as mass in her left breast after 6 years maintained continuous complete remission. No leukemic lesions were identified other sites such the bone marrow or cerebrospinal fluid. The relapsed cells revealed same immunophenotypes (CD10+, CD19+, CD20+, HLA-DR+, CD34+) those onset ALL marrow. literature survey found 10 cases without involvement, mostly consisting adolescent girls. Including present report,...
Allogeneic stem cell transplantation is a curative treatment for severe congenital neutropenia (SCN). However, standard conditioning regimen and donor source have not been established. We report 3 consecutive cases of SCN who were successfully treated by cord blood (CBT) with reduced-intensity consisting fludarabine, melphalan, low-dose total body irradiation. All achieved complete chimerism without infectious complications maintained normal neutrophil counts between 9 years after CBT. These...
Although bone marrow failure in patients with dyskeratosis congenita (DKC) can be successfully treated allogeneic hematopoietic cell transplantation (allo-HCT) using a reduced intensity conditioning (RIC) regimen, the outcome of nonhematological disorders DKC allo-HCT RIC has not been fully elucidated. Here, we describe clinical course after 3 consecutive DKC. Allo-HCT was feasible all cases; however, patient 1 developed lethal pulmonary disease and 2 experienced progression hepatic...
Management of cases refractory neuroblastoma remains a challenge. As intensive chemotherapy sometimes results in severe regimen-related toxicity and poor quality life, palliative with modest may be considered for these cases. We report 2 stage 4 performance status that received low-dose protracted schedules irinotecan. This regimen achieved not only disease stabilization but also dramatic improvements life significant periods. A schedule irinotecan was tolerable even if the patient's poor,...
Relapsed anaplastic large cell lymphoma (ALCL) is chemosensitive, but recurrence common. Although vinblastine (VLB) monotherapy an effective treatment for relapsed ALCL, the optimal duration unknown, and some patients experience further relapse after completing treatment. Allogeneic hematopoietic stem transplantation (allo-HSCT) also although transplant-related toxicity a problem. Here, we report 11-year-old patient with ALCL who underwent induction therapy VLB achieved complete remission...