A5089713492- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Dialysis and Renal Disease Management
- Respiratory Support and Mechanisms
- Liver Disease Diagnosis and Treatment
- Venous Thromboembolism Diagnosis and Management
- Cardiac Arrest and Resuscitation
- Renal and Vascular Pathologies
- Heparin-Induced Thrombocytopenia and Thrombosis
- Colorectal Cancer Surgical Treatments
- Hernia repair and management
- Antiplatelet Therapy and Cardiovascular Diseases
- Cardiac, Anesthesia and Surgical Outcomes
- Herpesvirus Infections and Treatments
- Cardiovascular Function and Risk Factors
- Acute Kidney Injury Research
- Pneumocystis jirovecii pneumonia detection and treatment
- Neurological and metabolic disorders
- Diagnosis and treatment of tuberculosis
- Organ Donation and Transplantation
- Atrial Fibrillation Management and Outcomes
- Diabetic Foot Ulcer Assessment and Management
- Disaster Response and Management
- Heart Failure Treatment and Management
Weber State University
2023
Parker Adventist Hospital
2021
Washington University Medical Center
2015-2017
George Washington University
2015-2017
University of Colorado Denver
2011-2014
Denver Health Medical Center
2011-2014
American Association for the Surgery of Trauma
2013-2014
Learning Partnership
2014
American College
2013
Foundation for the National Institutes of Health
2013
The acute coagulopathy of trauma is present in up to one third patients by the time admission, and recent CRASH-2 MATTERs trials have focused worldwide attention on hyperfibrinolysis as a component trauma. Thromboelastography (TEG) powerful tool for analyzing fibrinolyis, but clinically relevant threshold defining has yet be determined. Recent data suggest that accepted normal upper bound 7.5% 30-minute fibrinolysis (LY30) TEG inappropriate severe trauma, risk death rises at much lower...
Thromboelastography (TEG) is emerging as the standard in management of acute coagulopathies injured patients. Although TEG sensitive detecting abnormalities clot strength, one shortcoming differentiating between fibrinogen and platelet contributions to integrity. Current American algorithms suggest transfusion, whereas European guidelines concentrates for correcting low strength. Therefore, we hypothesized that a TEG-based functional (FF) assay would assess contribution platelets strength...
Venous thromboembolic (VTE) disease has a high incidence following trauma, but debate remains regarding optimal prophylaxis. Thrombelastography (TEG) been suggested to be in guiding Thus, we designed phase II randomized controlled trial test the hypothesis that TEG-guided prophylaxis with escalating low-molecular weight heparin (LMWH), followed by antiplatelet therapy would reduce VTE incidence.Surgical intensive care unit trauma patients (n = 50) were receive 5,000 IU of LMWH daily...
To determine whether prehospital antiplatelet therapy was associated with reduced incidence of acute lung dysfunction, multiple organ failure, and mortality in blunt trauma patients.Secondary analysis a cohort enrolled the National Institute General Medical Sciences Trauma Glue Grant database.Multicenter study including nine U.S. level-1 centers.A total 839 severely injured patients at risk for failure (age > 45 yr, base deficit 6 mEq/L or systolic blood pressure < 90 mm Hg, who received...
Thromboelastography (TEG), used in liver transplant and cardiac surgery for nearly 50 years, has recently been applied to the trauma setting. Rodents are widely shock research, but known have differences their coagulation system compared with humans. Consequently, appropriate technique performing TEG requires modification of standard clinical protocol. was performed blood collected from femoral artery rodents, technical modifications were tested optimize results. Analysis citrated whole...
Venous thromboembolism (VTE) prophylaxis remains debated following trauma, and recommendations have not been established. Although hyperfibrinogenemia is a marker of proinflammatory states, it also contributes to thrombus formation. Postinjury common, but the effect on VTE has fully elucidated. Therefore, we hypothesized that heparin less effective for severe injury due hyperfibrinogenemia.In vitro studies evaluated thromboelastography (TEG) parameters in 10 healthy volunteers after addition...
Objective: We hypothesized that aerosolized inhaled hypertonic saline given at the onset of resuscitation will decrease acute lung injury following hemorrhagic shock, by inhibiting release epithelial derived proinflammatory mediators. Design: Animal study. Setting: Animal-care facility procedure room in a medical center. Subjects: Adult male Sprague-Dawley rats. Interventions: Rats underwent shock followed 2 hrs and 1 hr observation. In study group, nebulized was delivered end period after...
Early acute kidney injury (AKI) following trauma is associated with multiorgan failure and mortality. Leukotrienes have been implicated both in AKI lung injury. Activated 5-lipoxygenase (5-LO) colocalizes 5-LO-activating protein (FLAP) the first step of leukotriene production hemorrhagic shock (T/HS). Diversion postshock mesenteric lymph, which rich 5-LO substrate arachidonate, attenuates decreases 5-LO/FLAP associations after T/HS. We hypothesized that lymph diversion (MLD) will also...
The return of heparinized shed blood (SB) in trauma/hemorrhagic shock (T/HS) models remains controversial because potential anti-inflammatory properties. Although ubiquitous as an anticoagulant, heparin is ineffective on cellular coagulation antithrombotic agent. Therefore, we hypothesized that returning SB would paradoxically enhance acute lung injury (ALI) after T/HS the infusion activated platelets. Sprague-Dawley rats, anesthetized with pentobarbital, underwent laparotomy and...