A5030222788- Lipid Membrane Structure and Behavior
- Protein Kinase Regulation and GTPase Signaling
- TGF-β signaling in diseases
- Force Microscopy Techniques and Applications
- Cytomegalovirus and herpesvirus research
- Molecular Sensors and Ion Detection
- Hepatitis C virus research
- Analytical Chemistry and Sensors
- Analytical Methods in Pharmaceuticals
- Cell death mechanisms and regulation
- Protein Interaction Studies and Fluorescence Analysis
- Sphingolipid Metabolism and Signaling
- Nanofabrication and Lithography Techniques
- Surfactants and Colloidal Systems
- Biochemical and Molecular Research
- Bone Metabolism and Diseases
- Parvovirus B19 Infection Studies
- Cancer-related Molecular Pathways
- Scientific Measurement and Uncertainty Evaluation
- Melanoma and MAPK Pathways
- Immune Cell Function and Interaction
- Advanced Fluorescence Microscopy Techniques
Fundación Ciencias Exactas y Naturales
2011-2025
Consejo Nacional de Investigaciones Científicas y Técnicas
2011-2025
University of Buenos Aires
2011-2024
National Institute of Industrial Technology
2020
Instituto de Química y Fisicoquímica Biológicas
2011-2012
The global spread of viral diseases is a public health issue. Ribavirin (RBV) and mycophenolic acid (MPA) are well-known wide-spectrum antiviral agents. present study evaluated the potential bovine serum albumin (BSA) nanoparticles (NPs) as vehicle to improve efficacy molecules with activity. results demonstrated that NPs offer promising strategy for delivery drugs, improving their stability reducing toxicity compared free BSA-based effectively encapsulated hydrophilic such MPA water-soluble...
Lateral organization of biological membranes is frequently studied using fluorescence microscopy. One the most widely used probes for these studies 2-dimethylamino-6-lauroylnaphthalene (laurdan). The this probe sensitive to environment polarity, and thus laurdan reports local penetration water when inserted in membranes. Unfortunately, can only be under two-photon excitation due its low photostability. This a very important limitation, because there are not too many laboratories with...
The Rho GTPase Rac1 is involved in the control of cytoskeleton reorganization and other fundamental cellular functions. Aberrant activity its regulators common human cancer. In particular, deregulated expression/activity Rac GEFs, responsible for activation, has been associated to a metastatic phenotype drug resistance. Thus, development novel Rac1-GEF interaction inhibitors promising strategy finding new preclinical candidates. Here, we studied structure-activity relationships within family...
Lipid-protein interactions play an essential role in the regulation of biological function integral membrane proteins; however, underlying molecular mechanisms are not fully understood. Here we explore modulation by phospholipids enzymatic activity plasma calcium pump reconstituted detergent-phospholipid mixed micelles variable composition. The presence increasing quantities produced a cooperative increase ATPase enzyme. This activation effect was reversible and depended on...
A relevant question in cell biology with broad implications biomedicine is how the organization and dynamics of interacting membranes modulate signaling cascades that involve cell–cell contact. The functionalization surfaces supported lipid bilayers containing tethered proteins a particularly useful method to present ligands membrane-like mobility cells. Here, we generate micrometer-sized patches decorated proteins. uses an economic microcontact printing technique based on one-photon...
Rac1 (Ras-related C3 botulinum toxin substrate 1), is a member of the family Rho GTPases involved in dynamic control cytoskeleton reorganization and other fundamental cellular functions including growth, motility survival. Aberrant activity its regulators common human cancer. In particular, deregulated expression/activity Rac Guanine nucleotide Exchange Factors (GEFs), responsible for activation, has been largely associated to metastatic phenotype drug resistance. Thus, development novel...
<p>Rac1 (Ras-related C3 botulinum toxin substrate 1), is a member of the family Rho GTPases involved in dynamic control cytoskeleton reorganization and other fundamental cellular functions including growth, motility survival. Aberrant activity Rac1 its regulators common human cancer. In particular, deregulated expression/activity Rac Guanine nucleotide Exchange Factors (GEFs), responsible for activation, has been largely associated to metastatic phenotype drug resistance. Thus,...