A5013276469- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Asthma and respiratory diseases
- Psoriasis: Treatment and Pathogenesis
- CAR-T cell therapy research
- Parasites and Host Interactions
- Acute Myeloid Leukemia Research
- Immune Response and Inflammation
- Diabetes and associated disorders
- Dermatology and Skin Diseases
- Reproductive System and Pregnancy
- Immune cells in cancer
- Macrophage Migration Inhibitory Factor
- Immunodeficiency and Autoimmune Disorders
- Cutaneous Melanoma Detection and Management
- Research on Leishmaniasis Studies
- Coronary Artery Anomalies
- Cancer-related molecular mechanisms research
- Hematopoietic Stem Cell Transplantation
- Kawasaki Disease and Coronary Complications
- Medical and Biological Ozone Research
- FOXO transcription factor regulation
- Lung Cancer Research Studies
- Antimicrobial Peptides and Activities
Guangzhou Medical University
2015-2025
State Key Laboratory of Respiratory Disease
2021-2024
Second Affiliated Hospital of Guangzhou Medical University
2021-2024
First Affiliated Hospital of Guangzhou Medical University
2022
Harvard University
2014-2019
Dana-Farber Cancer Institute
2017-2019
Sun Yat-sen University
2006-2011
Natural killer (NK) cells play an essential role in the immune response to infection and cancer. After or during homeostatic expansion NK express a developmental program that includes contraction phase followed by formation of long-lived mature memory-like cells. Although this cell pattern is well established, underlying mechanisms ensure efficient transition remain largely undefined. Here we report deficient expression intracellular osteopontin (OPN-i) results defective responses IL-15...
Follicular regulatory T (TFR) cells are a specialized suppressive subset that controls the germinal center (GC) response and maintains humoral self-tolerance. The mechanisms maintain TFR lineage identity activity remain largely unknown. Here, we show expression of Blimp1 by FoxP3+ is essential for stability, entry into GC, activity. Deletion in reduced FoxP3 CTLA-4 increased pro-inflammatory cytokines spontaneous production autoantibodies, including elevated IgE. Maintenance stability...
T cell-dependent B-cell responses decline with age, indicating declined cognate helper activity of aged CD4 + cells for B cells. However, the mechanisms remain unclear. follicular (Tfh) cells, a novel subset, play an essential role in helping differentiation into long-lived plasma germinal center (GC) or short-lived In present study, we proposed that there might existe changes proportion, phenotype cytokine production blood Tfh healthy elderly individuals compared young individuals.The...
Graft-versus-host disease (GVHD) as a major complication after allogeneic hematopoietic stem cell transplantation is not well prevented now. We have observed that interleukin-22 (IL-22) produced by Th22, Th1, and Th17 cells participated in GVHD development our previous study. However, the role of IL-22 still ambiguous. The aim this study was to illuminate pathological or protective function potential mechanism process. In present study, we found compared with mice cotransferred bone marrow...
Lineage commitment and differentiation into CD4+ T cell subsets reflect an interplay between chromatin regulators transcription factors (TF). Follicular development is regulated by the Bcl6 TF, which helps determine phenotype follicular localization of both helper cells (TFH) regulatory (TFR). Here we show that Bcl6-dependent control mediated a complex formed Mi-2β-nucleosome-remodeling deacetylase (Mi-2β-NuRD). Formation this reflects contribution intracellular isoform osteopontin (OPN-i),...
CD25+Treg cells (CD4+CD25+Foxp3+ regulatory T cells) play a central role in the maintenance of peripheral self-tolerance and immune homoeostasis. A previous study showed that suppressed differentiation function Th1 vivo vitro. However, mechanism suppressing cell mediated by remains unclear. In present study, we found could reduce production IFN (interferon)-γ percentage IFN-γ-, IL-2 TNF-α-producing CD25-T under culture conditions suppress into dose-dependent manner. Moreover, these inhibit...
TLRs are involved in the regulation of immune responses. R-848, a TLR7/8 ligand, has potent anti-viral and anti-tumour properties been used as new response modifier for enhancing Th1 response. In this study, we found that R-848 significantly inhibited IgE synthesis from murine B cells at single cell levels by anti-CD40 plus IL-4-stimulated splenocytes, which acted on early stage differentiation to modulate synthesis. This inhibitory effect was not isotype specific it also IgG1 Moreover, had...
Children are prone to get infections, especially in the respiratory system and gut mainly because their immune is immature. T cells significantly contribute prevention of different helper cell (Th) subsets play anti-pathogen roles. Interleukin (IL)-22 producing by T-helper 22 (Th22) an important role host defense against Gram-negative bacterial organisms lung. 17 (Th17) protect extracelluar bacteria fungi at epithelial surface. However, there no report comparing IL-22 Th17 healthy young...
Abstract Background We have reported the positive association of cyclooxygenase 2 (COX-2)/prostaglandin E2 (PGE2) axis with liver fibrosis induced by Schistosoma japonicum ( Sj ) infection, and TLR4 signaling controlled this axis. However, how COX-2 regulates immune response during infection is still unclear. Methods Hematoxylin eosin staining was used to evaluate effect COX-2-specific inhibitor NS398 on granulomatous inflammation fibrosis. Flow cytometry explore frequency amount different...
Abstract With the development of artificial intelligence, technique improvement classification skin disease is addressed. However, few study concerned on current system International Classification Diseases, Tenth Revision (ICD)-10 Diseases and subcutaneous tissue, which now globally used for disease. This was aimed to develop a new taxonomy based cytology pathology, test its predictive effect compared ICD-10. A (Taxonomy 2) containing 6 levels (Project 2–4) developed represents individual...
Programmed cell death-1(PD-1)/Programmed death ligand-1 (PD-L1) immune check blockade is one remarkable advance in cancer immunotherapy treatment. Clinical trials studying the efficacy of PD-1 alone or combination with other therapy different types have been evaluated are under observation. Nasopharyngeal carcinoma, also called Cantonese cancer, occurs rarely western countries but common tumors head and neck South China. NPC type tumors, it quite distinct among tumors. Here, we would like to...
IL-22 is involved in psoriasis and exacerbates disease progression. Cyclosporine A (CsA) an immunosuppressant drug that has been used the treatment of for more than 20 years. We determined producing T cells their phenotype, demonstrated mainly produced by CD4+ memory not CD8+ peripheral blood from healthy adults. compared Th17 Th1 with percentages cells, majority Th subset blood, as percentage significantly larger or cells. analyzed correlation IL-22, IL-17 IFN-? adults, confirmed there a...