Hydrogen gas, which is produced during fermentation in the human colon, either excreted breath or metabolised by gut bacteria through a variety of pathways. These may include methanogenesis, dissimilatory sulphate reduction, and acetogenesis. To determine these routes predominates large intestine, stools were taken from 30 healthy subjects incubated as 5% (w/v) slurries with Lintner's starch. In 23 subjects, methane production was main method hydrogen disposal. remaining seven, high rates...

Breath methane has been measured in 1016 people from four populations resident Southern Africa which experience widely different risks of bowel cancer and other colonic diseases. Highly significant differences the proportion subjects with detectable breath were found; % producers--rural black 84, urban 72, white 52, Indian 41 (chi 2 121 p less than 0.001 3 df). There was a slight preponderance female producers over male (female 63%, males 57%) an age trend fewer older groups blacks Indians,...

Dietary starch that escapes digestion in the small intestine may be quantitatively more important than dietary fiber as a substrate for fermentation. The products of fermentation have implications pathogenesis colorectal cancer and other diseases large bowel, which are uncommon Africans but high prevalence Western populations.Maize porridge is staple most blacks South Africa. Stale maize (high-resistant [HRS]) seems to induce greater bowel fresh (low-resistant [LRS]).In present study,...

Tropical enteropathy is widespread throughout the tropics, but its pathogenesis unknown. T-cell activation has been demonstrated to result in vitro and animal models, occurs untreated patients with coeliac disease. We have therefore examined hypothesis that important of tropical enteropathy.Healthy black Zambian subjects were compared white South Africans. Quantitative microscopy was conducted on distal duodenal biopsies. Mucosal quantitated by dual colour immunofluorescence staining for CD3...

In Western communities diverticular disease occurs mainly in the sigmoid colon. This contrasts with Oriental populations, which diverticula occur right Diverticular has recently emerged black South Africans. study shows that this population predominantly descending The variable anatomic distribution of different ethnic groups implies fiber deficiency is not only factor responsible for condition. It suggested may comprise several entities causes.

The number of Africans in Johannesburg presenting with duodenal ulcers has steadily increased over the past 50 years. characteristics 105 patients ulcer who presented a Baragwanath Hospital were compared those matched and unmatched samples without gastrointestinal conditions same hospital. Men found to be significantly better educated than their controls, most had been born town, more them employed at higher, though not highest, educational levels. These data used test Susser9s proposition...

This study reflects the fact that cancer of large bowel is uncommon in South African Blacks, and colorectal polyps do not appear to constitute a precursor most cancers. Furthermore, it shown dietary factors associated with this Western populations are evident Black population. In White population, however, disease behaves similar way observed countries. Other definitive differences found were absence multiple synchronous cancers diverticular Blacks cancer. It thus postulated absent, or have...

Diminished levels for fecal short chain fatty acids (SCFAs) have been linked to occurrence of ulcerative colitis, colorectal polyps, and colon cancer, diseases that are rare or uncommon in African populations. PURPOSE: The aim this study was determine SCFA concentrations pH values groups black South Africans (African) white (white) subjects. METHODS: Twenty healthy (all women; mean age, 35 years) 17 whites (7 10 men; 32 were tested. RESULTS: Mean total SCFAs the two 142.1 (±53.9) 69.2...

Among urban blacks in Johannesburg, South Africa, a measure of westernization diet has occurred. Yet, the frequencies most noninfective bowel diseases not only are low but also appear to have scarcely increased. To assess more adequately current dietary pattern, survey was undertaken. Results indicated habitually low-fat intake, which supplied mean 24% energy greatly decreased fiber intake (now about 14 g daily). Possibly, meaningful rise incidence requires, among other things, simultaneous...

Certain regions of South Africa exhibit an extraordinarily high incidence esophageal carcinoma that develops via esophagitis-dysplasia-carcinoma sequence. Bacteria belonging to the family Helicobacteraceae are candidates for involvement in initiation esophagitis. We investigated patients with occurrence Helicobacter-related species.Biopsies from tumor and nonlesional tissue esophagus nine squamous cell were using a PCR-based method targeting 16S rRNA gene.Four out tested negative, while...