A5052662894- Porphyrin and Phthalocyanine Chemistry
- Asymmetric Synthesis and Catalysis
- Organic and Inorganic Chemical Reactions
- Chemical synthesis and alkaloids
- Chemical Reaction Mechanisms
- Radical Photochemical Reactions
- Phenothiazines and Benzothiazines Synthesis and Activities
- Oxidative Organic Chemistry Reactions
- Catalytic C–H Functionalization Methods
- Inorganic and Organometallic Chemistry
- Enzyme Catalysis and Immobilization
- Metal-Catalyzed Oxygenation Mechanisms
- Advanced Synthetic Organic Chemistry
- Synthetic Organic Chemistry Methods
- Porphyrin Metabolism and Disorders
- Metal complexes synthesis and properties
- Axial and Atropisomeric Chirality Synthesis
- CO2 Reduction Techniques and Catalysts
- Photochromic and Fluorescence Chemistry
- Cholinesterase and Neurodegenerative Diseases
- Radioactive element chemistry and processing
- Organic Chemistry Cycloaddition Reactions
- Chemical Synthesis and Reactions
- Synthesis and Reactivity of Sulfur-Containing Compounds
- Catalysis for Biomass Conversion
Indian Institute of Science Education and Research, Bhopal
2020-2024
Canadian Nuclear Laboratories
1965
University of Nottingham
1960
A. W. Johnson, I. T. Kay, E. Markham, R. Price and K. B. Shaw, J. Chem. Soc., 1959, 3416 DOI: 10.1039/JR9590003416
E. Bullock, A. W. Johnson, Markham and K. B. Shaw, J. Chem. Soc., 1958, 1430 DOI: 10.1039/JR9580001430
Dimerized 3-substituted 2-oxindoles are essential building blocks for the total synthesis of alkaloids. Herein, three different types 3-substituted-2-oxindoles were dimerized with a 41 examples employing TEMPO as redox mediator and TEMPO+ an in situ generated electrocatalyst using control potential electrolysis at applied only 0.8 V versus Ag/Ag+ nonaqueous reference electrode. These reactions did not yield any product formation absence TEMPO, keeping other experimental conditions same....
A. W. Johnson, E. Markham, R. Price and K. B. Shaw, J. Chem. Soc., 1958, 4254 DOI: 10.1039/JR9580004254
The proofs of the structures proposed for Chlorobium pheophorbides 650, fractions 1–5, and 660, 5 6, are completed degradational evidence, where parallel, confirmed through synthesis derived porphyrins.
Dimerization of 3-substituted 2-oxindoles has been developed under a mild electrochemical condition, avoiding toxic chemical oxidants and metal by-products. This methodology forms C(sp3)-C(sp3) bond at the pseudobenzylic position two partners with broad substrate scope. These dimeric structural motifs are important building blocks for total synthesis pyrroloindoline alkaloids. Furthermore, this work demonstrates in-depth mechanistic insights employing electrochemistry, which suggests...
When 2-aminophenylsulfonylacetic acid (3) was heated under reflux in an excess of dilute sodium hydroxide solution, the only product identified 2-methylsulfonylaniline (6). 2-nitrophenyl-sulfonylacetic treated same conditions, major products were 2-methyl-sulfonylnitrobenzene (7), 2-nitrophenol (8), and orthanilic (13); minor this reaction 6 3-methylsulfonyl-3′-nitro-4-amino-4′-hydroxybiphenyl (12). The obtained although yields different when 7 boiled with alkali, but...
An efficient electrochemical oxidation strategy for the total synthesis of a dimeric hexahydropyrrolo[2,3-b]indole alkaloid, (±)-folicanthine (1b), has been envisioned. Control experiments suggest that PCET pathway involving stepwise electron transfer followed by proton (ET-PT) was involved in key oxidative dimerization process.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTSynthetic Porphyrins Related To Chlorobium ChlorophyllsJ. L. Archibald, S. F. MacDonald, and K. B. ShawCite this: J. Am. Chem. Soc. 1963, 85, 5, 644Publication Date (Print):March 1, 1963Publication History Published online1 May 2002Published inissue 1 March 1963https://pubs.acs.org/doi/10.1021/ja00888a040https://doi.org/10.1021/ja00888a040research-articleACS PublicationsRequest reuse permissionsArticle Views35Altmetric-Citations6LEARN ABOUT THESE...
The N,N-dimethylcarbamates of 3-quinuclidinol, 1-methyl-3-piperidinol, and 1-methyl-4-piperidinol have been prepared found to be weak inhibitors acetylcholinesterase. acetates the above alcohols were also moderately good substrates for this enzyme.
Like the known II, 5-halo-dipyrrylmethenes IV, X, and XI were obtained conventionally by halogenating pyrroles I IX. The 5-free dipyrrylmethene VIII, a new type of intermediate in such halogenations, was from pyrrole ester VII. four hydrolyzed to 5-hydroxy derivatives VI XIII, these reconverted into 5-chloro-dipyrrylmethenes.
Abstract An efficient asymmetric approach to the ergot alkaloids has been achieved via a highly regioselective Heck cyclization. Asymmetric induction of key intermediate was catalytic enantioselective α-aminoxylation catalyzed by d-proline (98% ee). Utilizing aforementioned strategy, formal total synthesis (+)-lysergine and (+)-isolysergine achieved. Importantly, an unnatural analogues (–)-lysergine (–)-isolysergine also using l-proline.
We envisioned a novel asymmetric strategy to access unsymmetrically substituted dimeric 2-oxindoles [(
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When N-(2-methylsulfonylphenyl)hydroxylamine (4) was treated with dilute sodium hydroxide solution the major product always 2,2′-di(methylsulfonyl)azoxybenzene (5). At room temperature other significant products were 2-hydroxy-2′-methylsulfonylazoxybenzene (6a) and 2-methylsulfonylnitrobenzene (2), while 6a also formed at reflux together small amounts of 2-hydroxy-2′-methylsulfonylazobenzene (8), 2-methylsulfonylaniline (7), 3-methylsulfonyl-3′-nitro-4-amino-4′-hydroxybiphenyl (3), 2. The...
Abstract Durch Behandlung des Hydroxylamins (I) mit wäßriger NaOH entstehen als Hauptprodukt das Azoxybenzol (II) und ferner Nebenprodukte bei Raumtemperatur (III) Nitrobenzol (IV) bzw. beim Kochen am Rückfluß neben Azobenzol (V), Sulfon (VI) Biphenyl (VII).
Abstract Durch Erhitzen des Sulfons (I) unter Rückfluß mit wäßriger NaOH im Überschuß wird als einziges Produkt das Anilin (II) erhalten.