A5018010990- Bone Tissue Engineering Materials
- Dental Implant Techniques and Outcomes
- 3D Printing in Biomedical Research
- Additive Manufacturing and 3D Printing Technologies
- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Electrospun Nanofibers in Biomedical Applications
- Periodontal Regeneration and Treatments
- biodegradable polymer synthesis and properties
- Metabolism, Diabetes, and Cancer
- Collagen: Extraction and Characterization
- Magnesium Alloys: Properties and Applications
- Mesenchymal stem cell research
- Heterotopic Ossification and Related Conditions
- Bone health and treatments
- Hemostasis and retained surgical items
- Autophagy in Disease and Therapy
- Cell Adhesion Molecules Research
- Mitochondrial Function and Pathology
- Pomegranate: compositions and health benefits
- Bone and Dental Protein Studies
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Cancer Cells and Metastasis
- Endodontics and Root Canal Treatments
Inserm
2005-2025
Université de Bordeaux
2012-2025
Laboratory for the Bioengineering of Tissues
2020
McGill University
2008-2017
Nantes Université
2005-2007
Le Laboratoire d'Ingénierie Ostéo-Articulaire et Dentaire
2005-2007
Abstract Autografts remain the gold standard for orthopedic transplantations. However, to overcome its limitations, bone tissue engineering proposes new strategies. This includes development of biomaterials such as synthetic polymers, serve scaffold production. The objective this present study was produce poly(lactic) acid (PLA) scaffolds different pore size using fused deposition modeling (FDM) technique and evaluate their physicochemical biological properties. Structural, chemical,...
Osteoclasts are giant bone cells formed by fusion from monocytes and uniquely capable of a complete destruction mineralized tissues. Previously, we have demonstrated that in energy-rich environment not only osteoclast index (the number nuclei each contains), but also cytoplasm volume per single nucleus was increased. The goal this study to investigate the regulation metabolic sensor mTOR during differentiation simulated addition pyruvate. We found presence pyruvate, proportion associated...
SCAPs (Stem Cells from Apical Papilla), derived the apex of forming wisdom teeth, extracted teenagers for orthodontic reasons, belong to MSCs (Mesenchymal Stromal Cells) family. They have multipotent differentiation capabilities and are a potentially powerful model investigating strategies clinical cell therapies. Since autophagy—a regulated self-eating process—was proposed be essential in osteogenesis, we investigated its involvement SCAP model. By using combination chemical genetic...
Perfluorodecalin (PFD) is a chemically and biologically inert biomaterial and, as many perfluorocarbons, also hydrophobic, radiopaque has high solute capacity for gases such oxygen. In this article we have demonstrated, both in vitro vivo, that PFD may significantly enhance bone regeneration. Firstly, the potential benefit of was demonstrated by prolonging survival marrow cells cultured anaerobic conditions. These findings translated where incorporated into bone-marrow-loaded 3D-printed...
Cell differentiation leads to adaptive changes in energy metabolism. Conversely, hyperglycemia induces malfunction of many body systems, including bone, suggesting that metabolism reciprocally affects cell differentiation. We investigated how the bone-resorbing osteoclasts, large polykaryons formed through fusion and growth cells monocytic origin, is affected by excess substrate pyruvate during osteoclast Surprisingly, small increases (1-2 mM above basal levels) augmented osteoclastogenesis...
Abstract Synthetic bone substitutes, such as calcium phosphate ceramics, give good results in clinical applications. In order to adapt surgical sites, bioceramics come the form of blocks or granules, and are either dense porous. Combining these with fibrin glue provides a mouldable self‐hardening composite biomaterial biochemical properties each component. Critical‐sized defects femoral condyle rabbits were filled TricOs/fibrin glue/bone marrow hybrid/composite material. The TricOs granules...
During breast cancer metastasis to bone, tumor cells home bone marrow, likely targeting the stem cell niche, and stimulate osteoclasts, which mediate osteolysis required for expansion. Although osteoblasts contribute regulation of hematopoietic niche control osteoclastogenesis through production proresorptive cytokine RANKL (receptor activator NF-κB ligand), their role in metastases is not fully understood. C57BL/6J mouse marrow were treated 3–12 days with ascorbic acid (50 μg/ml) presence...
Many studies have shown that bone is a dynamic organ, in which cell communication plays central role. A production of relevant vitro models appears essential to better understand the cellular interactions. The conventional monocultures are hindered by oversimplification and unable reproduce complex features processes investigated. Here, our aim was establish an original triculture model allowing retention phenotype formation, resorbing, vasculature forming cells. Human marrow stromal cells...