A5043471345- Neuropeptides and Animal Physiology
- Natural product bioactivities and synthesis
- Essential Oils and Antimicrobial Activity
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Regulation of Appetite and Obesity
- Estrogen and related hormone effects
- Piperaceae Chemical and Biological Studies
- Analytical Chemistry and Chromatography
- Botanical Research and Applications
- Phytochemistry and Biological Activities
- Receptor Mechanisms and Signaling
- Medicinal Plant Pharmacodynamics Research
- Cancer, Stress, Anesthesia, and Immune Response
- Biochemical Analysis and Sensing Techniques
- Diet and metabolism studies
- Marine and coastal ecosystems
- Cytokine Signaling Pathways and Interactions
- Bee Products Chemical Analysis
- Medicinal Plants and Neuroprotection
- Pharmacological Effects of Natural Compounds
- Neuroscience and Neuropharmacology Research
- Heavy Metals in Plants
- Growth Hormone and Insulin-like Growth Factors
- Adipose Tissue and Metabolism
- Psidium guajava Extracts and Applications
University of Cuenca
2009-2024
KU Leuven
2007-2010
Abstract Objective The aim of the present study was to adapt and optimize a broth microdilution method compare it agar dilution for evaluation activity essential oils from medicinal plants against Gram-negative bacteria. Based on bibliographic research, active not were selected. sensitivity specificity established as parameters validation. comparison between both methods made using contingency analysis tables, based observed frequencies. For methods, minimum inhibitory concentration...
The objective of this study was to evaluate the antioxidant capacity by spectrophotometric methods, in vitro and vivo antifungal effect against Lasiodiplodia theobromae constitution essential oils (EO) oregano thyme comparison with their commercial counterparts. results showed EOs extracted (T-EO), (CT-EO), (O-EO) (CO-EO), demonstrated profiles a radical neutralizing potential (DPPH•) IC50: 1.11± 0.019; 1.08 ± 0.05; 40.56 0.227 0.69 0.004 mg/mL, respectively. They also revealed ferric ion...
Summary The tropical Andes has a high density of glacial lakes that are situated in the high‐altitude páramo (3500–4500 m). Ecological information about such is scant despite fact these an important source water for drinking, irrigation and electricity generation feed several major tributaries Amazon. In this study, we provide data on survey 31 Cajas National Park (Ecuador). Two were monitored monthly during one year. situ nutrient addition experiments carried out three lakes. Seasonal...
Guayusa (Ilex guayusa Loes.) leaves, native of the Ecuadorian Amazon, are popularly used for preparing teas. This study aimed to assess influence leaf age on phenolic compounds and carotenoids bioactivity digestibility (in vitro) aqueous hydroalcoholic extracts.In total, 14 were identified quantified. Chlorogenic acid quercetin-3-O-hexose main representatives hydroxycinnamic acids flavonols respectively. Seven quantified, lutein being compound. Ripening affected content significantly, but...
Mortiño is a member of the Ericaceae family native to Andes that has been used by local communities for centuries. This species shown potential in areas medicine, agronomy, and green technology. We multidisciplinary approach review aspects related ecology, horticulture, composition biotechnological applications mortiño. As interest this grows, care must be taken identify opportunities justify its sustainable use while emphasizing development communities. Mapping wide variety uses current...
Acute intraperitoneal (i.p.) administration of cholecystokinin (CCK) is known to induce a significant, but short-lasting, reduction in food intake, followed by recovery within hours. Therefore, we had covalently coupled CCK 10 kDa polyethylene glycol and showed that this conjugate, PEG-CCK(9), produced significantly longer anorectic effect than unmodified CCK(9). The present study assessed the dose-dependency response two selective CCK(1) receptor antagonists, with different abilities cross...
The physiological involvement of endogenous cholecystokinin (CCK) in the termination feeding has been challenged by evidence aversive effects exogenous CCK8. We previously prolonged anorectic effect CCK conjugation to polyethylene glycol (PEGylation) produce PEG-CCK9. In this study, we investigated ability different doses PEG-CCK9 induce conditioned taste aversion (CTA) and satiety identified receptors involved CTA induction.Induction CTA, measured saccharin preference ratio determined a...
Aerial parts (leaves, flowers, stem) of Peperomia galioides extract administered to mice, was used confirm its anti-inflammatory and sedative folk uses. The activity assessed by croton oil-induced ear oedema myeloperoxidase (acute inflammation); cotton pellet-induced granuloma (sub-acute inflammation) Escherichia coli Lipopolysaccharide (LPS) induced inflammation (cellular mediators). studied the pentobarbital-induced sleeping time test. Single doses (300 600 mg/kg; i.p.) reduced activity....
Cholecystokinin, produced in the proximal small intestine, is a short acting satiating peptide hormone. CCK-10, before and after mono-iodination, was previously coupled to 10kDa polyethylene glycol (PEG). The formed conjugates PEG10kDa-CCK-10 PEG10kDa-[127I]-CCK-10 show i.p. administration rats sustained food intake reduction during 8h comparison 2h for free CCK-10. present study examined blood pharmacokinetics of this pharmacological interesting molecule by means PEG10kDa-[123I]-CCK-10...
The iodination of CCK-10 and coupling with PEG 10kDa is described along evaluation their food intake reducing effects in vitro stability. Labeling was performed by electrophilic substitution both [127I] [123I] iodide, using iodo-beads® as the oxidant. reaction conditions were optimised. HPLC used to follow progression for purification labeled compounds. synthesized compounds characterized MALDI-TOF MS 1H NMR spectroscopy. Radiochemical yields 40 ± 3% [123I]CCK-10; conjugation quantitative. A...