A5101562022- Hormonal and reproductive studies
- Muscle metabolism and nutrition
- Mass Spectrometry Techniques and Applications
- Pharmacological Effects and Assays
- Analytical Chemistry and Chromatography
- Pesticide Residue Analysis and Safety
- Analytical Methods in Pharmaceuticals
- Metabolomics and Mass Spectrometry Studies
- Estrogen and related hormone effects
- Renal function and acid-base balance
- Pharmacology and Obesity Treatment
- High Altitude and Hypoxia
- Sulfur Compounds in Biology
- Exercise and Physiological Responses
- Plant-based Medicinal Research
- Chromatography in Natural Products
Beijing Sport University
2022-2024
China Anti-Doping Agency
2013-2021
Abstract Small peptide hormones are widely used in sports as performance‐enhancing substances, making it crucial to develop sensitive analytical methods for their detection doping control analysis. Various factors significantly affect sensitivity, such the selection of ultra‐performance liquid chromatography (UPLC) mobile phase, high‐resolution mass spectrometry (HRMS) scanning modes, and extraction solvents pretreatment. Herein, comparative study approach was utilized investigate...
Abstract Higenamine is a β2‐agonist that has been included in the Prohibited List of World Anti‐Doping Agency (WADA) since 2017. Meanwhile, it exists plumula nelumbinis , part lotus seed, and commonly used as an ingredient cuisines, herbal medicines, nutritional supplements China other countries East Asia. Therefore, evaluation risk adverse analytical finding (AAF) higenamine caused by products necessary doping control. In this study, 14 volunteers took capsules orally (0.34 g/caplet, 6...
A novel, reliable and sensitive liquid chromatography–tandem mass spectrometry (LC–MS-MS) method was developed with dynamic multiple reaction monitoring (dMRM) mode for the simultaneous screening of 71 stimulants 7 metabolites in human urine using unsophisticated MS instruments (Agilent triple-quadruple 6410 B spectrometer). With a known retention time an analyte, dMRM algorithm monitors each MRM transition only around its expected time. Therefore, enables maximization dwell times provides...
Since the World Anti-Doping Agency's (WADA) Prohibited List is updated on an annual basis, screening methods must be continually adapted to align with these changes. In accordance Technical Document-MRPL 2022, a newly combined, comprehensive, rapid and high-throughput doping control method has been developed for analysis of 350 substances different polarities in human urine using ultra-high performance liquid chromatography coupled Q Exactive Plus Hybrid Quadrupole-Orbitrap mass spectrometer...
An accurate quantitative method for four prohibited ephedrine substances in human urine has been established, based on ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS). The bias caused by pretreatment operations and matrix effects was reduced the dilute shoot method. good separation of isomers achieved with advantages UPLC instrument Agilent Poroshell 120 EC-C8 column. Stable ions were selected during analysis MS/MS. result validation experiment showed an...
This study described a reliable analytical method, which combines solid-phase extraction with LC-HRMS employing the parallel reaction monitoring mode, for screening and confirming small peptides in human urine.
Clomiphene and toremifene, two chlorine-containing selective estrogen receptor modulators (SERMs) with a common triphenylethylene structure, are prohibited by World Anti-Doping Agency (WADA) out-of-competition in-competition. In this paper, we investigated the metabolic pathway different drug metabolites in human urine collected from healthy volunteers liquid chromatography quadrupole time-of-flight mass spectrometry (LC-QTOF) accurate measurement. Four unreported of toremifene at m/z...