A5019536284- T-cell and Retrovirus Studies
- Animal Disease Management and Epidemiology
- Vector-Borne Animal Diseases
- RNA Research and Splicing
- Ion channel regulation and function
- Spectroscopy and Quantum Chemical Studies
- Photoreceptor and optogenetics research
Imperial College London
2022-2024
Science for Life Laboratory
2019
The human T-cell leukemia virus type 1 (HTLV-1) transactivator protein Tax has pleiotropic functions in the host cell affecting cell-cycle regulation, DNA damage response pathways and apoptosis. These actions of have been implicated persistence pathogenesis HTLV-1-infected cells. It is now known that tax expression occurs transcriptional bursts proviral plus-strand, but effects burst on transcription are not fully understood. We carried out RNA sequencing two naturally-infected clones...
A typical HTLV-1-infected individual carries >10 4 different T cell clones, each with a single-copy provirus integrated in unique genomic site. We previously showed that the HTLV-1 causes aberrant transcription flanking host genome and, by binding chromatin architectural protein CTCF, forms abnormal loops genome. However, it remained unknown whether these effects were exerted simply presence of or induced its transcription. To answer this question, we sorted T-cell clones into cells...
Abstract The human T-cell leukemia virus type 1 (HTLV-1) transactivator protein Tax has pleiotropic functions in the host cell affecting cell-cycle regulation, DNA damage response pathways and apoptosis. These actions of have been implicated persistence pathogenesis HTLV-1-infected cells. It is now known that tax expression occurs transcriptional bursts proviral plus-strand, but effects burst on transcription are not fully understood. We carried out RNA sequencing two naturally-infected...
Abstract A typical HTLV-1-infected individual carries >10 4 different T cell clones, each with a single-copy provirus integrated in unique genomic site. We previously showed that the HTLV-1 causes aberrant transcription flanking host genome and, by binding chromatin architectural protein CTCF, forms abnormal loops genome. However, it remained unknown whether these effects were exerted simply presence of or induced its transcription. To answer this question, we sorted T-cell clones into...