A5025485223- Healthcare Systems and Practices
- Frailty in Older Adults
- Health, Medicine and Society
- Dementia and Cognitive Impairment Research
- Health Systems, Economic Evaluations, Quality of Life
- Aging, Elder Care, and Social Issues
- Parkinson's Disease Mechanisms and Treatments
- Chronic Disease Management Strategies
- Hormonal and reproductive studies
- Menopause: Health Impacts and Treatments
- Estrogen and related hormone effects
- COVID-19 and healthcare impacts
- Health disparities and outcomes
- Venous Thromboembolism Diagnosis and Management
- Nutrition and Health in Aging
- Blood Pressure and Hypertension Studies
- Long-Term Effects of COVID-19
- Nutritional Studies and Diet
- Neurological Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Alzheimer's disease research and treatments
- Cardiovascular Health and Disease Prevention
- COVID-19 and Mental Health
- Employment and Welfare Studies
- Global Health Care Issues
Santé Publique France
2016-2025
Inserm
2009-2025
Institut thématique Santé Publique
2016-2025
Université de Bordeaux
2007-2025
Bordeaux Population Health
2007-2023
Laboratoire Écologie Fonctionnelle et Environnement
2023
Centre Hospitalier Universitaire de Toulouse
2023
Pharmac
2023
Université de Versailles Saint-Quentin-en-Yvelines
2016-2018
Université Paris-Sud
2008-2018
There is no consensus regarding the definition of frailty for clinical uses.A modified Delphi process was used to attempt achieve definition. Experts were selected from different fields and organized into five Focus Groups. A questionnaire developed sent experts in area frailty. Responses comments analyzed using a pre-established strategy. Statements with an agreement more than or equal 80% accepted.Overall, 44% statements concept 18% diagnostic criteria accepted. on value screening about...
Oral estrogen therapy increases venous thromboembolism risk among postmenopausal women. Although recent data showed transdermal estrogens may be safe with respect to thrombotic risk, the impact of route administration and concomitant progestogens is not fully established. We used from E3N French prospective cohort women born between 1925 1950 biennially followed by questionnaires 1990. Study population consisted 80 308 (average follow-up: 10.1 years) including 549 documented idiopathic first...
The benefit/risk analysis of hormone therapy in postmenopausal women is not straightforward and depends on cardiovascular disease. Evidence supports the safety transdermal estrogens importance progestogens for thrombotic risk. However, differential association oral with stroke remains poorly investigated. Furthermore, there are no data regarding impact progestogens.We set up a nested case-control study ischemic (IS) within all French aged 51 to 62 years between 2009 2011 without personal...
Objectives To investigate the relationship between frailty and incident vascular dementia ( V a D ). Design Seven‐year longitudinal study. Setting T hree‐ C ity S tudy, F rench prospective study designed to evaluate risk of cognitive decline attributable factors. Participants Five thousand four hundred eighty community‐dwelling persons aged 65 95. Measurements An expert committee established clinical diagnosis . Frailty was defined as having at least three following criteria: weight loss,...
Abstract Background Behavioural and psychological symptoms of dementia (BPSD) are often reported in institutions for the elderly. Objective To evaluate effectiveness a staff education intervention to manage BPSD older people with diagnosis dementia. Methods The trial was conducted 16 nursing homes; 306 patients presenting were selected. Nursing homes randomly allocated an group or control group. An 8‐week training programme main outcome measures Cohen‐Mansfield Agitation Inventory (CMAI)...
A high thrombin generation level has been associated with the risk of venous thrombosis. Whether changes in this biomarker are relevant to arterial disease remains unknown. We investigated association coronary heart (CHD) and acute ischemic stroke (AIS) elderly.We used data from Three-City study, a prospective cohort including 9294 subjects aged >65 years. After 4 years follow-up, case-cohort study was established. Using calibrated automated thrombography method, endogenous potential peak...
Background Age-associated decline in testosterone levels represent one of the potential mechanisms involved development frailty. Although this association has been widely reported older men, very few data are available women. We studied between and frailty women assessed sex differences relationship. Methods used cross-sectional from Toledo Study for Healthy Aging, a population-based cohort study Spanish elderly. Frailty was defined according to Fried's approach. Multivariate odds-ratios...
Subjective memory complaint (SMC) and restriction in cognitively-complex activities of daily living (such as instrumental ADL) are two early symptoms observed the prodromal phase dementia may represent useful alarm signals for general pract
Abstract Background: Adverse effects of higher endogenous estradiol (E2) levels on various clinical outcomes and determinants the frailty syndrome have recently been reported. However, there are no data about potential relationship between E2 frailty. We aimed to study association among older postmenopausal women not taking hormonal therapy. Methods: used from Toledo Study for Healthy Aging, a Spanish population-based cohort study. Frailty was defined according Fried's approach. Multivariate...
The fear of contracting coronavirus disease 2019 (COVID-19) and the preventive measures taken during health crisis affected both people's lifestyles system. This nationwide study aimed to investigate impact first wave COVID-19 pandemic on hospitalizations mortality related geriatric syndromes (GS) in older adults France. French National Health Data System was used compare hospital admissions (excluding main diagnosis COVID-19) rates (using multiple-cause initial-cause analyses, including or...
This cohort study assesses the risk of developing early-onset dementia in individuals who had preeclampsia and other hypertensive disorders during pregnancy.
Introduction Glycated haemoglobin (HbA1c) is currently the gold standard for assessing glycaemic control in diabetes, given established relationship with microvascular and macrovascular complications this condition. However, HbA1c affected by non-glycaemic factors, while also failing to provide data on hypoglycaemic exposure glucose variability, which are associated adverse vascular outcomes. Continuous monitoring (CGM)-derived metrics a more comprehensive assessment of glycaemia, but their...
This study aimed to build a predictive model identify frailty in the French national health data system (SNDS) so as create new tool monitor and anticipate disability burden associated with population ageing. We developed using 2012 wave of Health, Healthcare, Insurance Survey (ESPS) linked SNDS (n = 2,829). survey used Fried's phenotype gold standard. compared two statistical approaches - logistic regressions (stepwise LASSO selection) random forest predict probability based on different...
<i>Background/Aims:</i> Current findings suggest the existence of a category fast cognitive decliners with poorer prognosis but better treatment response. Our study aimed at confirming concept time Alzheimer’s disease (AD) diagnosis which best predicts mortality, in an unselected sample. <i>Methods:</i> 245 incident cases AD were selected from French longitudinal cohort PAQUID. We investigated different threshold decline [measured by annual loss points Mini Mental...
Abstract Objective The objective of this study was to examine the association plasma estradiol and testosterone with risk for dementia in elderly men. Methods Within population based Three‐City study, including 3650 men age 65 years older, a case–cohort design set up after 4‐years follow‐up. Baseline levels total 17‐β (Total‐E2), (total‐T) bioavailable (bio‐T) were measured all cases incident (n = 105) random sample cohort 413). Cox regression models used estimate multivariate steroid sex...