Contrary to modern guidelines for the treatment of hypertension, oral and sublingual antihypertensive medications are often used in real-world practice quickly reduce asymptomatic or low-symptom elevated blood pressure (BP). Doctors patients explain this by need "stop an uncomplicated hypertensive crisis" preventing cardiovascular events. Clinical trial data indicate that such approach, both prescription short-­acting drugs at outpatient inpatient levels, recommendations self-treatment not...

To project the 10-year clinical outcomes associated with single pill combination (SPC) therapies compared multi-pill regimens for management of hypertension in five countries (Italy, Russia, China, South Korea and Mexico).

To evaluate the 5-year results of renal denervation (RDN) in patients with resistant arterial hypertension (AH).The study included 14 to whom, during 2011-2013 period RDN has been completed. Before and after intervention, office blood pressure, quality life indicators according EQ-5D questionnaire, mass index bodies, kidney function were duly assessed.Five years RDN, BP decreased from 165/110 139/95 mm Hg. Art. (p<0.05), average number drugs 4.6 3.1. 12 months RDA, Life, based on...

ABSTRACT In situ measurements of individual dust grain parameters in the immediate vicinity a cometary nucleus are being carried by Rosetta spacecraft at comet 67P/Churyumov–Gerasimenko. For interpretation these observational data, model motion as realistic possible is requested. particular, results Stardust mission and analysis samples interplanetary have shown that particles highly non-spherical. many cases precise simulations non-spherical grain’s dynamics either impossible or...

Aim. To study the effect of renal denervation on blood pressure (BP), myocardium function and vegetative status in patients with resistant hypertension (HT). Material methods. Patients a provisional HT diagnosis (n=62; 41.3% male) were included into study. 17 selected for after correction previous antihypertensive therapy examination to exclude symptomatic HT. Two refused procedure, 1 patient hadn’t undergone due anatomical features (renal artery diameter &lt;4 mm). Renal was performed 14...

Up-to-date European approaches to the management of patients with atrial fibrillation (AF) after acute coronary syndrome and/or percutaneous interventions are considered. Features antithrombotic therapy in early (hospital) and delayed periods (up 1 year ischemic events) discussed. The authors briefly present subanalysis ARISTOTLE study, which compares efficacy safety apixaban these warfarin a history heart disease.

Despite the possibilities of contemporary pharmacotherapy, more than 80% hypertensive patients do not achieve target blood pressure levels. Besides obvious reasons – poor adherence to treatment and non-rational therapy, there are other objective risk factors resistance. Three main modifiable causes resistant hypertension, that often underestimated, considered: obesity, obstructive sleep apnea syndrome primary hyperaldosteronism. Understanding these mechanisms resistance their diagnostic...

Aim. To evaluate the effectiveness of telmisartan as a component triple antihypertensive therapy in patients with obesity and refractory arterial hypertension. Material methods. The study included 30 All received an angiotensin II receptor blocker (ARB) or angiotensin-converting enzyme inhibitor (ACE inhibitor) adequate dosage part that also includes calcium antagonist thiazide diuretic. Participants were randomly divided into two equal groups. In main group, (Dr. Reddy’s Laboratories) was...

Blood pressure (BP) is a highly variable physiological indicator. Most people have BP changes within 40-50 mmHg during the day. Various external factors (from patient’s position measurement to poor adherence therapy and abuse of short-acting antihypertensive drugs) affect assessed indicators. Evaluation average daily, intra-visit, as well long-term ("from visit visit") variability used in clinical practice. In past twenty years number major studies demonstrated that increased an independent...

A new method of non-drug treatment resistant hypertension – renal denervation is considered. General information about hypertension, denervation, the results clinical studies on efficacy and safety, as well own case are presented.

The problem of comorbidity cardiovascular diseases (CVD) and anxiety-depressive disorders is actively discussed in modern scientific literature. Taking into account the widespread prevalence anxiety depressive population, their negative impact on quality life functioning patients, prerequisites are accumulating for diagnosis treatment these conditions by non-psychiatric doctors. review presents current data risk factors, relationships principles diagnosing resistant arterial hypertension...

The review provides modern data on the examination and treatment tactics of patients with resistant arterial hypertension (RAH). prevalence RAH is about 10–15%, a significant proportion pseudo-resistance cases associated low adherence to therapy, inaccurate blood pressure measurement technique, increased stiffness in elderly. In RAH, it necessary exclude secondary hypertension, which drug use nonsteroidal anti-inflammatory drugs, nasal sympathomimetics, oral contraceptives, as well those...

Hypertensive urgency (HU) is a common reason particularly for elderly patients to seek medical advice. Severe asymptomatic hypertension and situational high blood pressure (BP) in with its variability frequently taken as HU. The use of short-acting antihypertensive drugs not only indicated these situations, but it may also increase the risk cardiovascular events (CVE). Over past decade, increased BP an independent predictor higher CVE. Among major groups drugs, there are calcium antagonists,...

Aim. Management of hypertension, a major cause mortality worldwide, is difficult, with adherence common problem. The present study aimed to estimate the long-term clinical outcomes associated different treatment pathways in people hypertension Russia. Material and methods. Outcomes were projected over 10 years using microsimulation model. Four (current practices (CTP), single drug dosage titration then sequential addition other agents [start low go slow, SLGS], free choice combination...

The article discusses the role of telmisartan in treatment arterial hypertension patients with metabolic syndrome. Telmisartan is second-generation type 1 angiotensin II receptor blocker, which has unique pleiotropic effects due to partial affinity for receptors that activate proliferation subtype y peroxisomes (PPARy) located adipose tissue. interrelation metaflamation, a specific chronic inflammatory process pathogenetic mechanisms development cardiovascular diseases, including...

Renal denervation is a novel promising approach for resistant hypertension management and it getting more widespread. In recent years, this procedure has been studied not only as method of additional reduction blood pressure in non-responders to standard antihypertensive therapy, but also way influencing other syndromes diseases, which are related sympathetic hyperactivity. The article provides review clinical trials renal patients with insulin resistance diabetes mellitus, left ventricular...

Abstract Background It is well established that single pill combination (SPC) therapies have the potential to improve patient adherence versus multi-pill regimens, thereby improving blood pressure control and clinical outcomes in populations with hypertension. Purpose To develop a microsimulation model, capturing different treatment pathways, project impact on of using for management hypertension five countries (Italy, Russia, China, South Korea Mexico). Methods The model was designed health...

Background. Current guidelines describe in detail the approaches to management of patients with resistant hypertension, however, real clinical settings number non-rational and ineffective combinations antihypertensive drugs used remains high. Aim. To analyze distribution different for treatment hypertension estimate proportion combinations. Methods. The retrospective analysis includes 117 outpatients hypertension. Resistant was defined as blood pressure that above goal despite concurrent use...

The COVID-19 pandemic poses a lot of questions for doctors regarding the treatment both coronavirus disease itself and comorbidities. It is known that SARS-CoV-2 enters cells through angiotensin-converting enzyme (ACE)-2 receptor, which raises question about permissibility use renin-angiotensin system (RAS) blockers, specifically ACE inhibitors, in these patients. Numerous cohort studies, single randomized controlled trials their meta-analyzes have demonstrated safety RAS blockers patients,...

A new method of non-drug treatment resistant hypertension – renal denervation is considered. General information about hypertension, denervation, the results clinical studies on efficacy and safety, as well own case are presented.