A5029381056- Respiratory viral infections research
- Single-cell and spatial transcriptomics
- SARS-CoV-2 and COVID-19 Research
University of Minnesota
2020-2021
The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how heterogeneity this diverse population contributes elements viral tropism pathogenesis, antiviral immunity, treatment response remdesivir. found that, while a variety epithelial types are susceptible infection, ciliated cells predominant target SARS-CoV-2. host protease TMPRSS2 was required for infection these cells. Importantly, remdesivir...
Abstract The human airway epithelium is the initial site of SARS-CoV-2 infection. We used flow cytometry and single cell RNA-sequencing to understand how heterogeneity this diverse population contributes elements viral tropism pathogenesis, antiviral immunity, treatment response remdesivir. found that, while a variety epithelial types are susceptible infection, ciliated cells predominant target SARS-CoV-2. host protease TMPRSS2 was required for infection these cells. Importantly, remdesivir...