A5049797230- Advancements in Transdermal Drug Delivery
- Dermatology and Skin Diseases
- Immune Response and Inflammation
- NF-κB Signaling Pathways
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Psoriasis: Treatment and Pathogenesis
Ajou University
2022-2024
Although conventional topical approaches for treating psoriasis have been offered as an alternative, there are still unmet medical needs such low skin-penetrating efficacy and off-target adverse effects. A hyaluronic acid nanoparticle (HA-NP) formed by self-assembly of HA-hydrophobic moiety conjugates has broadly studied a nanocarrier long-term target-specific delivery drugs, owing to their excellent physicochemical biological characteristics. Here, we identify HA-NPs therapeutics using in...
The aberrant secretion of proinflammatory cytokines by immune cells is the principal cause inflammatory diseases, such as systemic lupus erythematosus and rheumatoid arthritis. Toll-like receptor 7 (TLR7) TLR9, sequestered to endosomal compartment dendritic macrophages, are closely associated with initiation progression these diseases. Therefore, development drugs targeting dysregulated TLRs imperative mitigate inflammation. Here, we applied principles computer-aided drug discovery identify...