A5100335587- MicroRNA in disease regulation
- Circular RNAs in diseases
- Glutathione Transferases and Polymorphisms
- Genomics, phytochemicals, and oxidative stress
- Drug-Induced Hepatotoxicity and Protection
- Natural Antidiabetic Agents Studies
- Cancer-related molecular mechanisms research
- Carcinogens and Genotoxicity Assessment
- Pesticide Exposure and Toxicity
- Nanoparticle-Based Drug Delivery
- Mesenchymal stem cell research
- Liver Disease Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Tissue Engineering and Regenerative Medicine
- Immunotoxicology and immune responses
- Smoking Behavior and Cessation
- Folate and B Vitamins Research
- Aquaculture Nutrition and Growth
- Appendicitis Diagnosis and Management
- Immune Cell Function and Interaction
- Layered Double Hydroxides Synthesis and Applications
- Sleep and Work-Related Fatigue
- Telemedicine and Telehealth Implementation
- Grit, Self-Efficacy, and Motivation
- Phonocardiography and Auscultation Techniques
University of Allahabad
2014-2025
Central Institute of Fisheries Education
2019-2025
Guru Nanak Dev University
2014-2024
JSS Dental College and Hospital
2024
Singapore University of Social Sciences
2023
Post Graduate Institute of Medical Education and Research
2014-2020
Krishi Vigyan Kendra, Ghatkhed Amravati
2019
Cleveland Clinic Lerner College of Medicine
2018
Ganesh Shankar Vidyarthi Memorial Medical College
2018
Swami Devi Dyal Hospital and Dental College
2014
MicroRNA 21 (miR-21) is overexpressed in virtually all types of carcinomas and various hematological malignancies. To determine whether miR-21 promotes tumor development vivo, we knocked out the allele mice. In response to 7,12-dimethylbenz[ a ]anthracene (DMBA)/12- O -tetradecanoylphorbol-13-acetate mouse skin carcinogenesis protocol, -null mice showed significant reduction papilloma formation compared with wild-type We revealed that cellular apoptosis was elevated cell proliferation...
Indoleamine 2,3-dioxygenase 1 (IDO1) catalyzes the first and rate-limiting step in converting tryptophan to kynurenine. Chimeric antigen receptor (CAR) T cells are with recombinant receptors targeting tumor-associated antigens. The Food Drug Administration has approved CAR that target CD19 for treatment of advanced B cell leukemia lymphoma. However, therapy solid tumors been hampered by multiple obstacles. Preclinical clinical studies suggest combinatorial immune checkpoint blockade IDO1...
<h3>Background and aims</h3> Radiotherapy for neoplastic disease is associated with significant adverse enteric effects excessive cell death. Ionising radiation induces death by a mechanism that dependent on JNK (c-jun N-terminal kinase) pathway signalling. Additionally, it known cells exposed to extracellular bacterial products such as flagellin, pleiotropically activate number of innate immune pathways, including JNK. The controls its own activity inducing the transcription...
Education has a significant effect on the behaviour and profession of individual. It prepares students for career so that they can earn their livelihood. Thus, selecting an appropriate is most important decision human beings have to make in lives. This will affect them throughout lives, nothing more than choosing career. When career, individuals struggle between two or situations need be resolved, known as conflicts. In today's world, where there are several options available, pressure...
Background: Neurological disorders such as Alzheimer’s disease (AD), Parkinson’s (PD), stroke, and spinal cord injury (SCI) are significant global health challenges due to their complex pathology limited therapeutic options. Conventional treatments often fail efficiently cross the blood–brain barrier (BBB), leading poor bioavailability systemic toxicity. This narrative review explores potential of nanomedicine in addressing these limitations advancing targeted therapies for neural disorders....
<title>Abstract</title> This study investigates the effects of melatonin supplementation on gonadotropin gene expression, vitellogenin (Vtg) antioxidant status, ovarian histology, and reproductive performance in female <italic>Clarias magur</italic>. Four experimental diets were formulated: control (0 mg/kg melatonin), T1 (100 T2 (200 T3 (300 melatonin). Results showed no significant difference weight gain between groups, while decreased notably T3. Gonadosomatic index (GSI) fecundity...
The present study aims to evaluate the survival status of patients with gallbladder cancer (GBC) and explore prognostic factors for improvement preventions.The consists 176 clinically diagnosed cancer; was conducted between 2019 2021 registered at Kamala Nehru Memorial Cancer Hospital, Prayagraj, India. rates were analyzed by Kaplan-Meier method; rate difference log-rank test, prognosis factors; hazard ratio mortality outcomes estimated using Cox regression method.The overall median time 5...
Abstract The cytogenetic effects of deltamethrin (DEL) and/or isoproturon (ISO) were examined in human lymphocytes and mouse bone marrow cells. Peripheral exposed to DEL (2.5, 5, 10, or 20 μM), ISO (25, 50, 100, 200μM), + (2.5 25, 5 10 200 μM) cytogenic evaluated via chromosomal aberrations (CA) the cytokinesis‐block micronucleus assay (CBMN). Mice orally gavaged single dose (6.6 mg/kg), (670 DEL+ISO 670 mg/kg) for 24 hr (3.3 mg/kg/day), (330 330 mg/kg/day) 30 days analyzed CA. induced a...
Telemonitoring is a medical practice that involves remotely monitoring patients who are not at the same location as health care provider. The purpose of our study was to use handheld tele-electrocardiogram (ECG) developed by Bhabha Atomic Research Center (BARC) identify heart conditions in rural underserved population where doctor-patient ratio low and access difficult. objective clinical validation tele-ECG screening tool for evaluation cardiac diseases population. ECG obtained 450...
Abstract An elevated level of homocysteine (Hcy) leads to hyperhomocysteinemia (HHcy), which results in vascular dysfunction and pathological conditions identical stroke symptoms. Hcy increases oxidative stress increase blood–brain barrier permeability leakage. Hydrogen sulfide (H 2 S) production during the metabolism has a cerebroprotective effect, although its effectiveness Hcy‐induced neurodegeneration neurovascular is less explored. Therefore, current study was designed perceive...
Aim: In this case control study involving, 220 human subjects; polymorphisms in xenobiotic metabolizing genes (GST-M1, -T1 and -P1) their association to lung cancer risk is being analysed among smokers nonsmokers. GSTM1 or GSTT1 gene polymorphism amino acid changes GSTP1 have been correlated may be associated risk. Other factor includes exposure environmental pollutants life style choices. We explored gene-gene gene-environment interaction the aetiology of north Indian population. Patients...
We conducted this study to investigate the effect of insufflation pressure on pathophysiology CO(2) pneumoperitoneum and embolism in an infant model. Twenty anesthetized piglets had stepwise intraperitoneal with for 15 min at pressures ranging from 5 20 mm Hg. The were ventilated baseline normocarbia (ETCO(2) = 30 Hg, PaCO(2) 38 Hg) before beginning each insufflation. was then insufflated IV these same pressures. There no reduction blood or cardiac output insufflation, but stroke volume...
Aim: The present study was conducted to optimize the dietary protein level in diet of Genetically Improved Farmed Tilapia reared inland ground saline water (IGSW) 15 ppt ambient salinity. Methodology: Seven iso-caloric (400 kcal digestible energy, DE/100g), iso-lipidic (6%) and hetero-nitrogenous (20-50% crude protein, CP) purified diets were prepared for conducting feeding trial. Following completely randomized design, random distribution 315 acclimatized fish (average body weight...
Diabetes mellitus is a chronic metabolic disease with the highest rates of prevalence and mortality worldwide. Chloroxylon swietenia has been used widely in folkloric medicine. Plants contain various phytoconstituents that are toxic. So it essential to carry out phytochemical screening toxicity studies medicinal plant. Both aqueous ethanolic leaf extracts (CSAE CSEE) were subjected preliminary tests for its presence or absence like alkaloids, carbohydrates, steroids, etc. Twenty-five albino...