A5005296726- Sexual function and dysfunction studies
- Sexuality, Behavior, and Technology
- Hormonal and reproductive studies
- Marriage and Sexual Relationships
- Hypothalamic control of reproductive hormones
- Adolescent Sexual and Reproductive Health
- Neuroendocrine regulation and behavior
- Evolutionary Psychology and Human Behavior
- Eating Disorders and Behaviors
- Sex and Gender in Healthcare
- Genital Health and Disease
- Genetic Associations and Epidemiology
Utrecht University
2011-2021
University Medical Center Utrecht
2011-2021
Emotional Brain (Netherlands)
2011-2021
Abstract Background In women, low sexual desire and/or arousal can lead to dissatisfaction and emotional distress, collectively defined as female interest/arousal disorder (FSIAD). Few pharmaceutical treatment options are currently available. Aim To investigate the efficacy safety of 2 novel on-demand pharmacologic treatments that have been designed treat FSIAD subgroups (women with sensitivity for cues women dysfunctional over-activation inhibition) using a personalized medicine approach an...
The study aimed to compare the kinetics of two novel combination drug products for Female Sexual Interest/Arousal Disorder (FSIAD). Thirteen women received testosterone via sublingual route followed 2.5 hours later by a buspirone tablet, versus single tablet swallowed at once. first clinical prototype consisted solution containing (0.5 mg) complexed with cyclodextrin and 10 mg buspirone, in gelatin capsule ensure blinding during studies. innovative fixed-combination consists an inner-core...
Attempts to develop a drug treatment for female sexual interest/arousal disorder have so far been guided by the principle of ‘one size fits all’, and failed acknowledge complexity sexuality. Guided personalized medicine, we designed two on-demand drugs targeting distinct hypothesized causal mechanisms this disorder. The objective study was design test novel procedure, based on genotyping, that predicts which will yield positive response. In double-blind, randomized, placebo-controlled...
Aim The aim was to compare the pharmacokinetic profiles of two formulations a combination drug product containing 0.5 mg testosterone and 50 sildenafil for female sexual interest/arousal disorder. prototype (formulation 1) consists solution sublingual administration tablet that is administered 2.5 h later. dual route/dual release fixed dose 2) employs an oral route systemic uptake. This has inner core with polymeric time delay coating outer testosterone. It designed increase dosing...
Phenotype Prediction Scores (PPS) might be powerful tools to predict traits or the efficacy of treatments based on combinations Single-Nucleotide Polymorphism (SNPs) in large samples. We developed a novel method produce PPS models for small samples sizes. The set SNPs is first filtered those known relevant biological pathways involved clinical condition, and then further repeatedly survival strategy select stabile positive/negative risk alleles. This applied Female Sexual Interest/Arousal...
Abstract Introduction A new combination tablet containing sublingual testosterone and oral buspirone (T+B) was developed to benefit a subgroup of women suffering from female sexual interest/arousal disorder, caused by dysfunctionally overactive inhibition. Aim The aim this study compare the effect food intake on pharmacokinetics buspirone, administered as dual-route, dual-release 0.5 mg (T) 10 (B). Methods 19 healthy took T+B under fed fasted conditions during 2 overnight visits. blood...