A5035170710- Opioid Use Disorder Treatment
- Skin Protection and Aging
- Substance Abuse Treatment and Outcomes
- Colorectal Cancer Screening and Detection
- Cutaneous Melanoma Detection and Management
- HIV, Drug Use, Sexual Risk
- Genetic factors in colorectal cancer
- Gastric Cancer Management and Outcomes
- Poisoning and overdose treatments
- Nonmelanoma Skin Cancer Studies
- Cardiac Arrest and Resuscitation
- Pain Management and Opioid Use
- Cardiovascular Issues in Pregnancy
- Cutaneous lymphoproliferative disorders research
- Food Security and Health in Diverse Populations
- Cervical Cancer and HPV Research
- Amyotrophic Lateral Sclerosis Research
- Behavioral Health and Interventions
- Endoplasmic Reticulum Stress and Disease
- Melanoma and MAPK Pathways
- Urban Green Space and Health
- CAR-T cell therapy research
- melanin and skin pigmentation
- Hereditary Neurological Disorders
- Public Health Policies and Education
McGill University
2024-2025
McGill University Health Centre
2024
BC Centre for Disease Control
2019-2023
University of British Columbia
2019-2023
Vancouver Coastal Health
2022
University of Cape Town
2014
Montreal Neurological Institute and Hospital
2013
McMaster University
2013
A familial form of Amyotrophic lateral sclerosis (ALS8) is caused by a point mutation (P56S) in the vesicle-associated membrane protein associated B (VapB). Human VapB and Drosophila Vap-33-1 (Vap) are homologous type II transmembrane proteins that localized to ER. However, precise consequences defects with P56S endoplasmic reticulum (ER) its role pathology ALS not well understood. Here we show Vap required for ER quality control (ERQC). Loss flies shows various ERQC defects, including...
Abstract Background Opioid related overdoses and overdose deaths continue to constitute an urgent public health crisis. The implementation of naloxone programs, such as ‘take-home naloxone’ (THN), has emerged a key intervention in reducing opioid deaths. These programs aim train individuals at risk witnessing or experiencing recognize respond with naloxone. Naloxone effectively reverses on physiological level; however, there are outstanding questions community THN program effectiveness...
ABSTRACT Background Breast cancer is the most commonly diagnosed among women in Canada. Screening effective reducing breast mortality through early detection. However, data on individual social and medical characteristics contributing to variation adherence screening limited. Methods Using multivariable logistic regression, we analyzed self‐reported questions engagement mammography from five regions of Canadian Partnership for Tomorrow's Health (CanPath), including BC Generations Project...
Introduction Take-Home Naloxone programs have been introduced across North America in response to rising opioid overdose deaths. There is currently limited real-world data on bystander naloxone administration, outcomes, and evidence related adverse events following administration. Methods The research team used descriptive statistics from administration forms. We explored reported demographic variables among people who received by-stander administered a suspected event between August 31,...
The mortality-to-incidence ratio (MIR) can be used to approximate healthcare inequities and is helpful understand/compare cancer survival between geographic regions/jurisdictions. We investigated cutaneous melanoma (CM) outcomes through MIR analysis in Canadian jurisdictions census divisions (CDs) 1992 2016.
The rapidly increasing skin cancer rates in Canada are alarming, with current data estimating that 1/3 of Canadians will be affected their lifetime. Thus, deeper understanding high-risk sun exposure behaviors is needed to help counter this trend. Only limited action has been taken by federal/provincial governments reduce incidence. A cross-sectional survey study was conducted Manitoba, frequency counts, means, and percentages used encapsulate responses. Age- gender-adjusted odds ratios were...
Introduction British Columbia's (BC) Take-Home Naloxone (THN) program provides naloxone to bystanders for use in cases of suspected opioid overdose. This study seeks provide trends and analysis from the provincial BC THN since inception 2012 end 2018. Materials methods shipment distribution records 2012–2018 were retrieved. Frequency distributions used describe characteristics individuals accessing program. To evaluate correlates after addition hundreds pharmacy sites, an analytic sample was...
Abstract Introduction The literature suggests that differential colorectal cancer (CRC) screening adherence exists between Canada’s immigrant and nonimmigrant populations. This study explores the impact of Ontario’s population program, ColonCancerCheck , on CRC uptake in groups. Methods Data from 2005, 2007‐2008, 2011‐2012 was obtained Canadian Community Health Survey, to represent intervention periods (the time before, during, after implementation intervention). Multivariable logistic...
Introduction: To address the increase in opioid-related overdoses and deaths Canada Good Samaritan Drug Overdose Act (GSDOA) was enacted May 2017. The GSDOA aims to reduce concerns of police attending overdose events encourage bystanders call emergency services. This study explores awareness understanding factors associated with among people who use drugs (PWUD).
 Methods: A cross-sectional drug harm reduction service survey containing GSDOA-specific questions wasconducted from October...
Introduction Although colorectal cancer (CRC) screening program is proven to reduce CRC incidence and mortality, understanding patterns predictors of suboptimal adherence in requires further investigation Canada. Methods We used self-reported data from five regional cohorts the Canadian Partnership for Tomorrow’s Health (CanPath), namely BC Generations Project (BCGP), Alberta’s Tomorrow (ATP), Ontario Study (OHS), Quebec’s CARTaGENE, Atlantic (Atlantic PATH). stratified participants into...
Abstract Background: Opioid related overdoses and overdose deaths continue to constitute an urgent public health crisis. The implementation of naloxone programs, such as ‘take-home naloxone’ (THN), has emerged a key intervention in reducing opioid deaths. These programs aim train individuals at risk witnessing or experiencing recognize respond with naloxone. Naloxone effectively reverses on biological level; however, there are outstanding questions community THN program effectiveness...
Background: Reflex molecular testing, the process of profiling specimens at diagnosis, is emerging in oncology, allowing for prompt therapy initiation, and potentially improving outcomes. This study evaluates impact reflex BRAF testing on treatment timelines outcomes melanoma, lung colorectal cancers McGill University Health Center (MUHC). Methods: A retrospective chart review was conducted MUHC. The included patients with lung, who underwent from 2017 to 2022. Data demographics, cancer...
Background: Skin cancer prevention relies on effective sun safety practices. Previous studies have shown that LGBTQ+ individuals exhibit lower sunscreen use and higher tanning bed usage compared to their non-LGBTQ+ counterparts. This study is the first assess skin risk factors, sun-protective behaviors, concerns among across Canada. Methods: A national survey was conducted between July 2020 March 2024 included respondents aged ≥ 16 years who had completed survey. Responses were summarized...
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Abstract Objectives To describe the methodology and key findings of British Columbia’s (BC) COVID-19 SPEAK surveys, developed to understand experiences, knowledge, impact pandemic on Columbians. Methods Two province-wide, cross-sectional, web-based population health surveys were conducted one year apart (May 2020 April/May 2021). Questions drawn from validated sources grounded within social determinants assess testing prevention; mental physical health; risk protective factors; healthcare,...