A5053859424- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Ion channel regulation and function
- Genetic Neurodegenerative Diseases
- Mitochondrial Function and Pathology
- Cardiac Arrest and Resuscitation
- Cardiovascular Effects of Exercise
- Cardiomyopathy and Myosin Studies
- ECG Monitoring and Analysis
- Climate Change and Health Impacts
- Ion Transport and Channel Regulation
- Neuroscience and Neuropharmacology Research
- Cardiac Structural Anomalies and Repair
- Cardiac Health and Mental Health
- Heart Failure Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Cardiac Imaging and Diagnostics
- Air Quality and Health Impacts
- Emergency and Acute Care Studies
- Mechanical Circulatory Support Devices
- Heart Rate Variability and Autonomic Control
- Cardiovascular Disease and Adiposity
- Diabetes Treatment and Management
University of Arkansas for Medical Sciences
2020-2025
University of Arkansas Medical Center
2022-2023
East Carolina University
2017-2021
Rutgers, The State University of New Jersey
2021
University of North Carolina at Chapel Hill
2010-2019
University of North Carolina Hospitals
2015-2018
J P Kenny
2016
University of North Carolina Health Care
2012-2015
University of Virginia
1996-2009
University of Virginia Health System
2000-2006
Myotonic dystrophy (DM; OMIM 160900, also known as dystrophia myotonica, myotonia atrophica and Steinert disease) is an autosomal dominant myotonic myopathy associated with abnormalities of other organs, including eyes, heart, endocrine system, central peripheral nervous systems, gastrointestinal bone, skin.1 The mutation underlying DM expansion unstable cytosine-thymine-guanine (CTG) trinucleotide repeat in the 3' untranslated region protein kinase (DMPK) gene chromosome 19q13.3.2-4 In...
Stroke and PV Ablation. Introduction: Radiofrequency (RF) ablation has become an established treatment modality for patients with paroxysmal atrial fibrillation (AF). A principal limitation of RF catheter is the risk thromboembolism. as a complication after triggers AF not been previously reported. Methods Results: Fifty‐six underwent focal source AF. Forty‐nine (86%) had in ≥1 pulmonary vein. Mean procedure time was 227 ± 74 minutes . Cerebrovascular event occurred 3 (5%) patients, all...
Background Symptoms attributed to atrial fibrillation (AF) are nonspecific, and it remains unclear what influences perception of symptoms. Anxiety or depression may be important in modulating AF However, few longitudinal studies have addressed this effect. Methods A total 378 patients with completed anxiety severity questionnaires as well symptom frequency questionnaires. Patients were offered treatment strategies including catheter ablation antiarrhythmic rate‐controlling medications....
Current guidelines recommend that the choice of AF management strategy be guided by symptomatic status patient when in AF. However, little is known regarding what drives symptoms. Several limited studies suggest psychological distress may linked with symptom severity.A total 300 patients documented completed a questionnaire assessing general health and well-being, including comprehensive assessment as well disease-specific measures severity. burden was determined 1-week continuous looping...
Background The left atrial posterior wall ( PW ) often contains sites required for maintenance of fibrillation AF ). Electrical isolation the is an important feature all open surgeries AF. This study assessed ability current ablation techniques to achieve PWI and its effect on recurrent . Methods Results Fifty‐seven consecutive patients with persistent or high‐burden paroxysmal underwent catheter ablation, which was performed using endocardial‐only (30) a hybrid endocardial–epicardial...
We have demonstrated previously that phospholemman (PLM), a 15-kDa integral sarcolemmal phosphoprotein, inhibits the cardiac Na+/Ca2+ exchanger (NCX1). In addition, protein kinase A phosphorylates serine 68, whereas C both 63 and 68 of PLM. Using human embryonic kidney 293 cells are devoid endogenous PLM NCX1, we first exogenous NCX1 current (INaCa) was increased by phorbol 12-myristate 13-acetate (PMA) but not forskolin. When co-expressed with resulted in: (i) decreases in INaCa, (ii)...
The effects of amrinone on human umbilical artery and myocardium were studied. Amrinone produced dose related increases in tension, dT/dtmax dT/dtmin from patients who NYHA grade I (n = 1) II 4). responses to these tissues similar the response seen normal guinea-pig 34). drug had no inotropic effect tissue III 5). was inversely length history severity heart failure whom obtained. caused relaxation artery. vasodilator properties, but not positive detectable at concentrations obtained during...
Bundle branch re-entrant (BBR) tachycardia is an uncommon form of ventricular (VT). This arrhythmia typically occurs in patients with a structural heart disease, especially dilated cardiomyopathy, and significant conduction system impairment, although affected structurally normal or have been reported. The QRS morphology during can vary; it has left bundle block (LBBB) which the antegrade over right retrograde limb bundle. reverse this circuit results (RBBB) morphology. A also utilize...
Rapid and precise control of Na(+)/Ca(2+) exchanger (NCX1) activity is essential in the maintenance beat-to-beat Ca(2+) homeostasis cardiac myocytes. Here, we show that phospholemman (PLM), a 15-kDa integral sarcolemmal phosphoprotein, novel endogenous protein inhibitor NCX1. Using heterologous expression system devoid both PLM NCX1, first demonstrated by confocal immunofluorescence studies exogenous NCX1 co-localized at plasma membrane. Reciprocal co-immunoprecipitation revealed specific...
Objective: To establish a method of implantation for device leads across total venous occlusions. Background: Indications pacemaker and implantable cardiac defibrillator continue to expand. Chronic occlusions are increasingly encountered with lead placement. Some degree obstruction can be as high 13% before 50% after transvenous implantation. We report an approach venoplasty/dilatation chronic allow Methods: From January 1, 2002 through December 16, 2004, 1,356 systems (initial upgrade) were...
Overexpression of phospholemman (PLM) in normal adult rat cardiac myocytes altered contractile function and cytosolic Ca 2+ concentration ([Ca ] i ) homeostasis inhibited Na + /Ca exchanger (NCX1). In addition, PLM coimmunoprecipitated colocalized with NCX1 myocyte lysates. this study, we evaluated whether the cytoplasmic domain is crucial mediating its effects on contractility, [Ca transients, activity. Canine or derived mutants were overexpressed by adenovirus-mediated gene transfer....
Messenger RNA levels of phospholemman (PLM), a member the FXYD family small single-span membrane proteins with putative ion-transport regulatory properties, were increased in postmyocardial infarction (MI) rat myocytes. We tested hypothesis that previously observed reduction Na + -K -ATPase activity MI myocytes was due to PLM overexpression. In hearts harvested 3 and 7 days post-MI, protein expression by two- fourfold, respectively. To simulate overexpressed normal adult adenovirus-mediated...