A5028587688- Poisoning and overdose treatments
- Pesticide Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Alcoholism and Thiamine Deficiency
- Renal function and acid-base balance
- Diet and metabolism studies
- Pharmacological Effects and Toxicity Studies
- Pesticide and Herbicide Environmental Studies
- Epilepsy research and treatment
- Opioid Use Disorder Treatment
- Cardiac electrophysiology and arrhythmias
- Insect and Pesticide Research
- Heavy Metal Exposure and Toxicity
- Cardiovascular Syncope and Autonomic Disorders
- Forensic Toxicology and Drug Analysis
- Pharmacology and Obesity Treatment
- Metabolism and Genetic Disorders
- Ion channel regulation and function
- Treatment of Major Depression
- Electroconvulsive Therapy Studies
- Animal Ecology and Behavior Studies
- Prenatal Substance Exposure Effects
- Respiratory and Cough-Related Research
- Pharmacovigilance and Adverse Drug Reactions
- Aluminum toxicity and tolerance in plants and animals
Wayne State University
2007-2021
Children's Hospital of Michigan
2011-2019
University of Michigan
2017
Boston Children's Hospital
2007-2010
Washington Poison Center
1988-2005
University of Massachusetts Chan Medical School
1990-2001
University of Massachusetts Boston
1991
Drexel University
1988-1989
Chester County Hospital
1987
Hennepin County Medical Center
1985
Methanol poisoning may result in metabolic acidosis, blindness, and death. The inhibition of alcohol dehydrogenase is fundamental to the treatment methanol poisoning. We performed a multicenter study evaluate fomepizole, an inhibitor dehydrogenase, patients with
Tianeptine (marketed as Coaxil or Stablon) is an atypical tricyclic drug used antidepressant in Europe, Asia, and Latin America. In the United States, tianeptine not approved by Food Drug Administration (FDA) for medical use unscheduled pharmaceutical agent* (1). Animal human studies show that opioid receptor agonist (2). Several case have reported severe adverse effects even death from recreational abuse of (3-5). To characterize exposures CDC analyzed all exposure calls related to poison...
AbstractBackground: Increased clearance and apparent clinical improvement in valproic acid overdose has been reported following in-series hemodialysis/hemoperfusion therapy. We report a case of divalproex sodium chlorpheniramine treated with charcoal hemoperfusion multiple-dose activated charcoal. Case Report: A 32-year-old female presented alert three hours postingestion her own medication. Serum was 105 μg/mL. No anticholinergic toxicity seen. Despite doses over 14 hours, serum continued...
Case Report: We report a case of methanol poisoning exhibiting complete recovery from severe visual impairment following treatment with ethanol, fomepizole, and hemodialysis. An adult male presented central blindness after ingesting methanol. Initial acuity was < 20/800 (finger counting at 1–2 feet) retinal edema on fundoscopy, arterial pH 7.19, 97 mg/dL (30 mmol/L), formate 14.3 mmol/L, ethanol undetectable. The patient treated then fomepizole intravenously (15, 10, 5 mg/kg), Methanol...
Objectives. To identify opioids associated with a spike in opioid-related mortality Wayne County, Michigan, from July 2016 through February 2017. Methods. We reviewed records the County Medical Examiner’s Office of 645 people who died because accidental nonmedically prescribed opioid overdoses 2015 analyzed basic demographics, locations death, and all toxicology results. Decedents hospitals were excluded. Results. Of overdoses, 65% male 63% White, an average age 43 years. Carfentanil was...
The threshold salicylate concentration commonly recommended to initiate extracorporeal elimination, in the absence of significant end-organ toxicity, is 100 mg/dL. Unfortunately, grade evidence support this decision low. Our primary aim describe highest reported concentrations patients who died from acute ingestions. secondary determine if age or coingestants varied with concentration.We analyzed fatalities National Poison Data System (NPDS) between 1 January 1986 and 31 December 2014....