A5067857880- Human Health and Disease
- Erythrocyte Function and Pathophysiology
- Medical and Biological Ozone Research
- Biochemical effects in animals
- Pregnancy and preeclampsia studies
- Neurological Disorders and Treatments
- Chemical Reactions and Isotopes
- Biomarkers in Disease Mechanisms
- Glutathione Transferases and Polymorphisms
- Nitric Oxide and Endothelin Effects
- Birth, Development, and Health
- Free Radicals and Antioxidants
- Phytochemicals and Antioxidant Activities
- Vitamin C and Antioxidants Research
- Electron Spin Resonance Studies
- Effects of Radiation Exposure
- Blood properties and coagulation
- Adipose Tissue and Metabolism
- COVID-19 Clinical Research Studies
- Muscle and Compartmental Disorders
- Thyroid Disorders and Treatments
- Child Abuse and Related Trauma
- Seed and Plant Biochemistry
- Hydrogen's biological and therapeutic effects
- Inflammation biomarkers and pathways
Ministry of Education and Science of Georgia
2025
Tbilisi State Medical University
2015-2024
Tbilisi State University
2011-2023
Biomechanics Institute of Valencia
2022
Czech Academy of Sciences, Institute of Biotechnology
2022
University of Georgia
2015-2019
Agricultural University of Georgia
2017
Center for Life Sciences
2013
Georgian National Academy of Sciences
2006
Study aimed at investigation of pathogenic role and prognostic value several selected cerebrospinal fluid acute phase factors that can reflect the severity ischemic brain damage. Ninety five stroke patients were investigated. Ischemic region visualized twenty fourth hour by conventional Magnetic Resonance Imaging. Stroke evaluated National Institute Health Scale. One month outcome disease was assessed Barthel Index. Cerebrospinal taken sixth onset. CSF pro- anti-inflammatory cytokines...
Summer savory (Satureja hortensis L., Lamiaceae) is used in several regions of the world as a spice and folk medicine. Anti-inflammatory cytoprotective effects S. its rosmarinic acid-rich phenolic fraction have been demonstrated animal trials. However, previous studies acid cell models yielded controversial results. In this study, we investigated summer extracts on H2O2-challenged human lymphoblastoid Jurkat T cells. LC-MS analysis confirmed presence flavonoids such hesperidin naringin...
The paper considers the issue of academic and institutional autonomy having become central to identity university how it remains a contemporary signifier relationship scholarly activity, society. This is particularly true in European Higher Education Area (EHEA), where management national higher education systems with different traditions seeks find comparative consistency levels quality their awards. Specifically, this Republic Georgia's reality, firstly, against other post-Soviet signatory...
The study aimed to assess the lifetime attributable risk of breast cancer associated with chest computed tomography (CT) exposure in female COVID-19 patients Georgia. Data was obtained from National Center for Disease Control and Public Health Georgia (NCDCG), concerning morbidity, hospitalization, mortality rates general population during period 2020–2021. Additionally, information on age distribution incidence among 2015 2023, as well demographic data Statistical Office years 2017 2019,...
The flowers of French marigold ( Tagetes patula L.) are widely used in folk medicine, particular for treating inflammation-related disorders. However, cellular mechanisms this activity demand further investigation. In the present work, we studied potential T. compounds to alleviate oxidative stress hydrogen peroxide-challenged human lymphoblastoid Jurkat T-cells. Crude extracts and purified fractions containing flavonoids patuletin, quercetagetin, quercetin their derivatives, as well...
The problem of food with functional ingredients, characterized by low energy intake and a variety phytonutrients biological activity, is one the concerns population. objectives this study were to investigate effect pumpkin powder its bioactive components on quality, color textural properties shortbread cookies. In drying process (Cucurbita moschata) at 60 ± 2 °C, physicochemical parameters did not change significantly in relation fresh pulp. chromatic L*, a* b* showed that was brighter than...
In coronary artery disease (CAD), an alternative way of improvement blood circulation in the ischemic area myocardium is collateral circulation. Our study aimed to investigate rheological parameters and nitric oxide (NO) content patients with various degrees development likelihood influence fluidity on angiogenesis.We studied stable CAD who underwent elective angiography a control group same mean age. We investigated different developing collaterals those without them. patients, plasma...
Prevention of Type 2 diabetes mellitus (T2DM) requires a modifying effect on the pathological processes inducing β-cell dysfunction.the comprehensive study violation rheological parameters in patients with different stages and identification possible links between these alterations intensity oxidative stress patient's body.60 IR, prediabetes, T2DM healthy volunteers were included. Full range patients' blood - indicators erythrocytes aggregation index (EAI), relative deformability membranes...
The study aimed to determine the osteointegration markers after dental implantation and evaluate their predictive value. was performed on 60 practically healthy persons who needed teeth rehabilitation using implants. conical-shaped implants (CI) hexagonal (HI) were used. content of Osteopontin (OPN), Osteocalcin (OC), Alkaline Phosphatase (ALP), Osteoprotegerin (OPG), nitric oxide (NO) determined in patients' gingival crevicular fluid (GCF) peri-implant sulcular (PISF), collected 1, 3, 6...
The mechanism of gallstone formation is not well understood. Abnormal regulation hepatic cholesterol, bile acid synthesis or esterification, deposition cholesterol monohydrate crystals and gall bladder dysfunction are thought to be the principal metabolic aberrations that may cause formation. One plausible leading these abnormalities role free radicals, whose presence can investigated using Electron Paramagnetic Resonance (EPR). Surgically removed stones were used obtain purified bilirubin,...
Modulation of endothelial function is a therapeutic option to reduce some the significant complications hypertension. However, relationship between dysfunction reduced nitric oxide (NO) production, and development hypertension not fully understood. To establish potential pathogenetic link impaired NO synthesis hypertension, we investigated results competitive interaction substrate synthase, L-arginine, its analog, an non-selective inhibitor N-nitro-methyl ether-L-arginine (L-NAME), in...
Ischemic heart disease is a pathological chronic and acute condition, which provoked by insufficient blood supply or its complete cessation. To reduce the number of patients, all approaches studies that can positively affect prevention treatment are important. This very important in monitoring treating diseases systems organs, especially cardiovascular system. The aim our work was to elucidate relationship between rheological status blood, vascular changes intracardiac hemodynamics failure...