A5013515348- Prenatal Screening and Diagnostics
- Gestational Trophoblastic Disease Studies
- Pregnancy and preeclampsia studies
- Genomic variations and chromosomal abnormalities
- Ectopic Pregnancy Diagnosis and Management
- Gestational Diabetes Research and Management
- Sexual Differentiation and Disorders
- Genomics and Rare Diseases
- Reproductive System and Pregnancy
- Endometriosis Research and Treatment
- Ubiquitin and proteasome pathways
- Genetic Syndromes and Imprinting
- Bariatric Surgery and Outcomes
- Ovarian function and disorders
- Ovarian cancer diagnosis and treatment
- Pregnancy-related medical research
- Hormonal Regulation and Hypertension
- Reproductive Biology and Fertility
- Adrenal Hormones and Disorders
- interferon and immune responses
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer, Hypoxia, and Metabolism
Guangzhou Medical University
2021-2022
Sichuan University
2016-2017
Embryonic aneuploidy is found in about half of sporadic pregnancy losses and the associations between chromosomal clinical characteristics loss remain unclear. The aims this study were to evaluate products conception (POC) features loss.We conducted a retrospective cohort including 1,102 women experienced singleton underwent microarray analysis (CMA) detection POC our hospital. results molecular karyotypes maternal age, history loss, gestational vaginal bleeding ultrasonographic findings...
Obesity has been linked to systemic inflammation in population studies.To examine the associations of prepregnancy body mass index (pBMI) and total gestational weight gain (tGWG) with maternal prepartum low-grade (LGI) clinically significant (CSI) defined by serum C-reactive protein (CRP) concentration.Five thousand four hundred seventy-six Chinese women uncomplicated pregnancies recorded data on pBMI were included this study. Blood samples drawn before delivery for high-sensitivity CRP...
Copy number variant (CNV) is believed to be the potential genetic cause of pregnancy loss. However, CNVs less than 3 Mb in euploid products conceptions (POCs) remain largely unexplored. The aim this study was investigate features POCs and their clinical significance loss/fetal death.
To analyze the clinical characteristics and genetic features of a family affected with isolated proteinuria.Clinical data was collected. Mutations 191 renal disease-related genes in proband were screened next generation sequencing (NGS). Sanger used to verify suspected mutations his members 100 healthy controls. The impact mutation predicted online software SIFT. Frequency searched databases including 1000 Genomic Project, ESP ExAC.NGS showed that harbored compound heterozygous ADCK4 gene...
Aim: To present the clinicopathologic findings of second case androgen-secreting adult granulosa cell tumor (AGCT) in a woman with polycystic ovary syndrome (PCOS) and discuss light literature. Methods: Description discussion Results: A patient oligomenorrhea, amenorrhea hirsutism who was diagnosed as PCOS treated by oral contraceptive for three years, then left ovarian solid liquid mass found pathologically confirmed to be AGCT after oophorectomy. She got regular menstrual cycle gave birth...
Pseudoachondroplasia (PSACH) is an autosomal dominant osteochondrodysplasia caused by mutations in the gene encoding cartilage oligomeric matrix protein (COMP). Accurate clinical diagnosis of PSACH sometimes difficult. Here, we identified a novel COMP mutation (c.1675G>A, p.Glu559Lys) Chinese family. We detected plasma levels and type II collagen (CTX-II) four affected individuals. The results showed significantly decreased CTX-II increased three patients with mutation. However, both were...
Abstract Background: Although first-trimester subchorionic hematoma (SCH) always concerns expectant parents, its clinical significance remains controversial. This study aimed to examine the relationship between SCH and association with subsequent miscarriage other perinatal outcomes. Methods: We conducted a retrospective cohort including 43,660 women who underwent routine prenatal care since first trimester then were followed up for maternal neonatal was detected in ultrasound examinations....