Triple-negative breast cancer (TNBC) is a genetically and morphologically heterogeneous group with aggressive biological behaviour specific response to therapy. It accounts for 15–20% of all cancers has two subtypes: basal like non-basal like. MicroRNAs, which regulate gene expression, play role in TNBC, potentially acting as oncogenes or tumor suppressors. Identification differentially expressed miRNA potential clinical relevance TNBC patients. In this study, profiling by microarray was...

ABSTRACT Objectives: For oral squamous cell carcinoma (OSCC), we are likely at a juncture in clinical management, where the benefits of therapies beginning to plateau. Therefore, this study investigated usefulness adenosine triphosphate (ATP)-binding cassette subfamily G member 2 (ABCG2), podoplanin (PDPN), and cluster differentiation (CD) 44 (CD44) that may help identify patients with an aggressive phenotype predict prognosis precisely. MATERIALS AND METHODS: The protein expression ABCG2,...

ABSTRACT Small cell carcinoma (SCC) is most commonly found in the lung. Extrapulmonary SCC has been reported various organs. Despite its rarity, primary pleural should be considered along with mesothelioma case of a pleura-based mass because difference prognosis and treatment. To highlight role morphology IHC arriving at diagnosis SCC. Pleural biopsy hematoxylin eosin-stained immunohistochemistry slides. Tumor cells were immunoreactive for synaptophysin, chromogranin, CK7, TTF1, BerEP4,...

Cutaneous and subcutaneous metastases from internal malignancies are rare indicate a dismal outcome for the patient. This study is designed to analyze cases of cutaneous known or unknown primary evaluate usefulness fine needle aspiration cytology as diagnostic modality. The present retrospective analysis 83 patients who were diagnosed with metastatic skin deposits on cytology. Seventy-four previously malignancy nine had simultaneously tumor. commonest showing breast, colon rectum, lung,...

Primary central nervous system lymphoma (PCNSL) is rare and accounts for 1-2% of all primary intracranial tumors (ICT). There are conflicting reports regarding the increased incidence PCNSL over last two decades in both immunocompromised immunocompetent patients.This study was designed to clinicopathological characteristics access trend at our institute.All histopathologically proven cases were reviewed from January 1997 December 2009 (13 years). Immunophenotyping performed on available...

The presence of sarcomatous element transforms the usually innocuous spermatocytic seminoma into a highly aggressive neoplasm. We report case with undifferentiated component in 43-year-old male, presented testicular mass since two and half years. Orchidectomy was performed after 9 months, patient recurrent scrotal bilateral pulmonary metastases.

Fibrous hamartoma of infancy (FHI) is a rare, benign tumor the subcutis and lower dermis, which usually occurs within first 2 years life. Ninety one percent tumors occur in year The histogenesis FHI unclear. clinical course typically prognosis excellent. physical characteristics subcutaneous mass child may suggest malignant process; however, should be included differential diagnosis. excellent with local surgical excision it rarely recurs.

Abstract Background Mucinous cystadenocarcinoma is a rare and recently described primary breast cancer with strikingly similar histomorphology to ovarian, pancreatic, gastrointestinal counterparts. The diagnosis cannot be made until the metastatic lesion ruled out. Case presentation We are reporting case of 65-year-old woman mucinous while exploring clinicopathological features approach diagnosis. Though immunohistochemistry panel CK7, CK20, CDX2, SATB2, PAX8, mammoglobin, GATA3 plays...

Astroblastoma is a rare primary glial tumor of children and young adults. Radiologically astroblastoma presents as large well-circumscribed supratentorial, solid-cystic heterogeneous mass. Histology shows perivascular pseudorosettes with hyalinization. Only single case has been reported signet-ring-like cell morphology. Signet-ring morphology in central nervous system tumors exceedingly rare. Complete surgical resection the recommended treatment. Prognosis depends on extent histology. The...

Spindle epithelial tumor with thymic like elements (SETTLE) is a biphasic composed of and spindle cell components. It an uncommon indolent arising in the thyroid gland most commonly affects children young adults. This entity mostly overlooked because its rarity diagnostic difficulty on morphology. We discuss two cases SETTLE varied presentation, challenges lessons learnt from them.SETTLE should be considered as differential especially when dealing lesion adolescent. The article discusses...

Background: Atypical glandular cells (AGCs) diagnosis on Pap (Papanicolaou) smears are uncommon and may represent various benign malignant lesions. Objective: This study aims to report the incidence of AGC smear, relationship with malignancy, determine cytomorphological features that help in predicting malignancy. Materials Methods: Retrospective analytical conducted Department Oncopathology at Tertiary Cancer Research Institute. In this retrospective study, we included cases diagnosed...

<br>Solitary plasmacytoma of the bone (SPB) is a rare plasma cell neoplasm representing only about 5% neoplasia. It usually presents as lytic lesion mainly localized within axial skeleton. SPB exceedingly in young individuals, and few cases have been reported so far patients younger than 20 years age. In view rarity disease, definitive treatment guidelines not established. We hereby report case involving lumbar vertebra (L5) 12-year-old boy. He was initially treated with antilymphoma therapy...

Brain metastases are the most common intracranial neoplasms. They often first symptom of systemic malignancy. Hence, immunohistochemistry (IHC) is importance in evaluating origin brain metastases.The aim was to detect primary site and evaluate role IHC diagnosing same.Data 74 patients with unknown analyzed. performed these cases. The histopathological findings were correlated clinical radiological data.Of cases which done; lung (51 cases). Even after applying IHC, could not be diagnosed 10...

Granulosa cell tumor (GCT) with synchronous mature teratoma is extremely rare and only eight cases are documented in the literature. GCT low-grade malignancy need a close follow up for recurrences which may be late. We report case of occurring synchronously same ovary perimenopausal woman.