A5036429392- Bacterial biofilms and quorum sensing
- Antimicrobial Resistance in Staphylococcus
- Plant Pathogenic Bacteria Studies
- Evolutionary Game Theory and Cooperation
- Bacterial Genetics and Biotechnology
- Evolution and Genetic Dynamics
- Antibiotic Resistance in Bacteria
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Microbial Natural Products and Biosynthesis
- Microbial Metabolic Engineering and Bioproduction
Emory University
2019-2024
Evolutionary Genomics (United States)
2023
University of Montana
2019-2020
Georgia Institute of Technology
2019-2020
Staphylococcus aureus has recently overtaken Pseudomonas aeruginosa as the most commonly recognized bacterial pathogen that infects respiratory tracts of individuals with genetic disease cystic fibrosis (CF) in United States. Most studies S. CF patient lung infections have focused on a few isolates, often exclusively laboratory-adapted strains, and how they are killed by P. Less is known about diversity isolates terms both their virulence interaction To begin to address this gap, we...
Staphylococcus aureus is a globally pervasive pathogen that produces plethora of toxic molecules can harm host immune cells. Production these toxins mainly controlled by an active agr quorum-sensing system, which senses and responds to bacterial cell density.
When cultured together under standard laboratory conditions Pseudomonas aeruginosa has been shown to be an effective inhibitor of Staphylococcus aureus . However, P. and S. are commonly observed in coinfections individuals with cystic fibrosis (CF) chronic wounds. Previous work from our group revealed that isolates CF infections able persist the presence strain PAO1 a range tolerances some being eliminated entirely others maintaining large populations. In this study, we designed serial...
The productivity of a biological community often correlates with its diversity. In the microbial world this phenomenon can sometimes be explained by positive, density-dependent interactions such as cross-feeding and syntrophy. These metabolic help account for astonishing variety life drive many biogeochemical cycles without which we know it could not exist. While is difficult to recapitulate experimentally how these evolved among multiple taxa, explore in laboratory they arise within one....
Chronic bacterial infections are often polymicrobial, comprising multiple species or variants of the same species. Because chronic may last for decades, they have potential to generate high levels intraspecific variation through within-host diversification over time, and superinfections occur introduction pathogen populations ongoing infection. Traditional methods identifying infective agents generally involve isolating one single colony from a given sample, usually after selecting specific...
ABSTRACT Community productivity often correlates with diversity. In the microbial world this phenomenon can sometimes be explained by highly-specific metabolic interactions that include cross-feeding and syntrophy. Such help account for astonishing variety of life, drive many biogeochemical cycles without which life as we know it could not exist. While is difficult to recapitulate experimentally how these evolved among multiple taxa, explore in laboratory they arise within one. These...
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Abstract Pseudomonas aeruginosa and Staphylococcus aureus are the most common bacteria that infect respiratory tract of individuals with genetic disease cystic fibrosis (CF); in fact, S. has recently overtaken P. to become common. Substantial research been performed on epidemiology CF; however, there appears be a gap knowledge regard pathogenesis context CF lung infections. Most studies have focused few isolates, often exclusively laboratory adapted strains, how they killed by . Because...
Abstract Staphylococcus aureus is a prominent nosocomial pathogen that causes several life-threatening diseases such as pneumonia and bacteremia. S. modulates expression of its arsenal virulence factors through sensing integrating responses to environmental signals. The agr (accessory gene regulator) quorum (QS) system major regulator phenotypes in . There are four specificity groups each with different autoinducer peptide sequence (encoded by the agrD gene). Though critical for many toxins,...