A5012411495- Immune Response and Inflammation
- Neutropenia and Cancer Infections
- Vitamin D Research Studies
- Blood disorders and treatments
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Hematopoietic Stem Cell Transplantation
- Vitamin C and Antioxidants Research
- Drug Transport and Resistance Mechanisms
- Parathyroid Disorders and Treatments
- Sphingolipid Metabolism and Signaling
- Genetic Syndromes and Imprinting
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Electrolyte and hormonal disorders
- Immunotherapy and Immune Responses
- Food composition and properties
- Hair Growth and Disorders
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Spaceflight effects on biology
- Thyroid and Parathyroid Surgery
- Blood groups and transfusion
- Cardiac Valve Diseases and Treatments
- Acute Lymphoblastic Leukemia research
- Neurogenetic and Muscular Disorders Research
- Genomics, phytochemicals, and oxidative stress
- Biotin and Related Studies
Osaka Ohtani University
2021-2023
The University of Tokyo
2015-2020
Mitsui Sugar (Japan)
2006
Tokai University
1990
Chukyo Hospital
1977
A purified human granulocyte colony-stimulating factor (hG-CSF) was studied for its protective effect on the induction of neutropenia and enhanced susceptibility to microbial infections in mice receiving cyclophosphamide (CPA). severe reduction peripheral blood neutrophils induced 4 days after injection with 200 mg CPA per kg although level normalized rapidly thereafter. When were injected subcutaneously once a day 2.5 micrograms hG-CSF beginning injection, prevented markedly, even later. On...
A method of separating neutrophils from the peripheral blood rats with 95% purity is described. To determine role antigenic stimulation in neutrophil function, front germ‐free (GF) were compared those conventional (CV) rats. Neutrophil counts lower GF but total number monocytic cells was same. measure phagocytic killing, superoxide anion production determined and found to be (2.1 ± 0.5 nmol/min. 10 6 cells) than CV (9.5 2.9 nmol/min/10 cells). Myeloperoxidase activity twofold higher...
We studied the effects of in vivo administrations recombinant human granulocyte colony-stimulating factor (rhG-CSF) on metastasis murine hematogenous and non-hematogenous tumors spontaneous experimental models. Spontaneous lung caused by intra-footpad injections B16-BL6 melanoma Lewis-lung-carcinoma (3LL) cells were inhibited intravenous (i.v.) subcutaneous (s.c.) rhG-CSF after excision primary tumors. Recombinant hG-CSF significantly liver when administered i.v. injection L5178Y-ML25...
Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) is a rare disorder, caused by bialellic mutations of the vitamin D receptor (VDR) gene, sometimes associated with alopecia. The aim this study to elucidate mechanism functional disruption novel mutation, detected in patient HVDRR, comparing other or without was 2-year-old girl alopecia, who clinically diagnosed as HVDRR. Genetic analysis revealed homozygous S360P, located ligand binding domain (LBD). mutation predicted not disease...
Context Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) is an autosomal recessive disease caused by biallelic mutations in the vitamin D receptor (VDR) gene. No patients have been reported with uniparental disomy (UPD). Objective Using genome-wide single nucleotide polymorphism (SNP) array to confirm whether HVDRR was UPD of chromosome 12. Materials and Methods A 2-year-old girl alopecia short stature without any family history consanguinity diagnosed typical laboratory data...
Hereditary 1,25-dihydroxyvitamin D-resistant rickets (HVDRR) is caused by mutations in the VDR gene, and its inheritance autosomal recessive. In this report, we aimed to confirm whether HVDRR occasionally inherited as a dominant trait. An 18-month-old Japanese boy was evaluated for short stature bowlegs. His father had been treated during childhood, his paternal grandfather We diagnosed him with based on laboratory data radiographic evidence of rickets. Sequence analyses were performed,...
<b><i>Introduction:</i></b> Autosomal dominant hypophosphatemic rickets (ADHR) is caused by pathogenic variants in the <i>fibroblast growth factor 23</i> (<i>FGF23</i>) gene, which plays a key role regulation of phosphorus metabolism. FGF23 has RXXR motif recognized furin, leading to cleavage between R179 and S180 thereby inactivating protein’s function. Previously reported <i>FGF23</i> causing ADHR occurred only affecting residues...
Smith-Lemli-Opitz syndrome is an autosomal recessive disease caused by mutations in 7-dehydrocholesterol reductase (DHCR7), which rarely observed Japan. We report a Japanese case with 46,XY disorder of sex development and Y-shaped 2-3 toe syndactyly. DHCR7 gene analysis revealed compound heterozygous including the novel mutation H442R. Early diagnosis led to starting cholesterol treatment at early age.
Objectives: Our study aimed to clarify the trend of vitamin D deficiency and rickets diagnosed in past 10 years. Methods: This observational used health insurance claims data from 2005 2014. The number beneficiaries for 2014 were 91 617 365 800, respectively. We included children aged 0 15 years with or D-deficient rickets; those congenital/secondary low-birth-weight infants excluded. analyzed patients temporal these diseases Japan. Results: annual 2008 was <5. 2009 3.88 (95% confidence...
Abstract Background Hereditary vitamin D-resistant rickets (HVDRR) is caused by D receptor (VDR) defects. Patients with HVDRR do not respond to standard doses of calcitriol and oral calcium (Ca) treatment need be treated intravenous Ca (IV-Ca) via a central route. However, catheter-related complications can cause significant morbidity. Case presentation Four unrelated patients presenting alopecia totalis were administered intermittent IV-Ca (2–5 times/week) through peripheral No such as...
Background Menthol exerts relaxing, antibacterial, and anti-inflammatory activities, is marketed as a functional food therapeutic drug. Aim In the present study, effects of menthol on expression multidrug resistance associated protein 2 (MRP2) its association with cytotoxicity epirubicin (EPI) cisplatin (CIS) were examined using HepG2 cells. Methods The levels target genes by real-time PCR. intracellular concentration incorporated EPI was measured high-performance liquid chromatography. Cell...
Epirubicin (EPI), an epimer of doxorubicin (DOX), and DOX are anthracycline agents with broad-spectrum antitumor activity. The aim the present study was to elucidate transport characteristics EPI in human hepatocellular carcinoma HepG2 cells non-small cell lung cancer A549 cells, examine relationship intracellular drug accumulation their cytotoxic effects.Intracellular concentrations were measured using high-performance liquid chromatography (HPLC). Expression level targeted genes analyzed...
Department of Artificial Organs, Division Research, and Cardiac Surgery, Chukyo Hospital, Nagoya, Japan.