A5008213823- Photoreceptor and optogenetics research
- Neuroscience and Neuropharmacology Research
- Retinal Development and Disorders
- Memory and Neural Mechanisms
- Receptor Mechanisms and Signaling
- Energy, Environment, Economic Growth
- Environmental Sustainability in Business
- Neurogenesis and neuroplasticity mechanisms
- Hearing, Cochlea, Tinnitus, Genetics
- Nicotinic Acetylcholine Receptors Study
- Environmental Impact and Sustainability
Yale University
2021-2023
Shandong University of Finance and Economics
2023
Tsinghua University
2019
Abstract In the developing auditory system, spontaneous activity generated in cochleae propagates into central nervous system to promote circuit formation. The effects of peripheral firing patterns on are not well understood. Here, we describe wide-spread bilateral coupling that coincides with period transient efferent modulation inner hair cells from brainstem medial olivocochlear system. Knocking out α9/α10 nicotinic acetylcholine receptors, a requisite part pathway, profoundly reduces...
Fear extinction is generally considered a form of new learning that inhibits previously acquired fear memories. Here, by tracking immediate early gene expression in vivo, we found contextual training evoked distinct neural ensembles mouse retrosplenial cortex (RSC). The optogenetic reactivation these extinction-activated neurons the RSC was sufficient to suppress response, while conditioning-activated same area promoted response. generation such an extinction-memory-related ensemble...
Long-term potentiation (LTP), a well-characterized form of synaptic plasticity, is believed to underlie memory formation. Hebbian, postsynaptically expressed LTP requires TARPγ-8 phosphorylation for insertion AMPA receptors (AMPARs). However, it unknown whether TARP-mediated AMPAR alone sufficient modify behavior. Here, we report the development chemogenetic tool, ExSYTE (Excitatory SYnaptic Transmission modulator by Engineered TARPγ-8), mimic cytoplasmic interaction TARP with plasma...
Abstract Mammalian vision starts in the retina. The study of retinal circuits vivo is essential for comprehending neural dynamics under physiological conditions. While several transpupillary retina imaging techniques have been utilized anesthetized animals, situ activity awake animals has more difficult to accomplish. These limits frustrated crucial scientific inquiries, such as how visual processing modulated by behavior. In this study, we present novel experimental approaches that...
Abstract Spontaneous retinal waves are a critical driving force for the self-organization of mouse visual system prior to eye-opening. Classically characterized as taking place in three distinct stages defined by their primary excitatory drive, Stage II during first postnatal week propagated through volume transmission acetylcholine while III second depend on glutamatergic from bipolar cells. However, both late and early share defining propagation bias toward temporal-to-nasal direction...