About
Contact & Profiles
A5037572615
Research Areas
- Circular RNAs in diseases
- MicroRNA in disease regulation
- RNA Research and Splicing
- RNA regulation and disease
- interferon and immune responses
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
Center for Excellence in Molecular Cell Science
2019-2025
University of Chinese Academy of Sciences
2019-2025
10.1016/j.cell.2019.03.046
article
EN
publisher-specific-oa
Cell
2019-04-25
10.1038/s41592-020-01011-4
article
EN
Nature Methods
2020-12-07
10.1038/s41587-024-02204-4
article
EN
Nature Biotechnology
2024-04-23
10.1016/j.molcel.2021.11.019
article
EN
publisher-specific-oa
Molecular Cell
2021-12-23
10.1016/j.scib.2025.02.027
article
EN
Science Bulletin
2025-02-01
Summary Circular RNAs (circRNAs) produced from back-spliced exons are widely expressed, but individual circRNA functions remain poorly understood due to inadequate methods, such as RNAi and genome engineering, in distinguishing overlapped circRNAs those linear cognate mRNAs 1,2 . Here we report that the programable RNA-guided, RNA-targeting CRISPR-Cas13, RfxCas13d, effectively specifically discriminates mRNAs, using guide (g)RNAs targeting sequences spanning back-splicing junction (BSJ)...
10.1101/2020.03.23.002865
preprint
EN
cc-by-nc-nd
bioRxiv (Cold Spring Harbor Laboratory)
2020-03-25
10.1016/j.ymeth.2021.01.011
article
EN
Methods
2021-02-09
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