A5100318594- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Phytochemical Studies and Bioactivities
- Natural product bioactivities and synthesis
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Extracellular vesicles in disease
- Bioactive Compounds and Antitumor Agents
- MicroRNA in disease regulation
- Natural Compounds in Disease Treatment
- Inflammatory mediators and NSAID effects
- Genetic Associations and Epidemiology
- Medicinal Plant Pharmacodynamics Research
- Glioma Diagnosis and Treatment
- Global Cancer Incidence and Screening
- Marine Sponges and Natural Products
- Bioinformatics and Genomic Networks
- Beetle Biology and Toxicology Studies
- Phytochemistry and Bioactive Compounds
- Breast Cancer Treatment Studies
- Gene expression and cancer classification
- Breast Lesions and Carcinomas
- Hedgehog Signaling Pathway Studies
- RNA modifications and cancer
Creative Commons
2024
Kunming Medical University
2024
First Affiliated Hospital of Kunming Medical University
2024
Xian Yang Central Hospital
2022
Peking University First Hospital
2015-2021
Peking University
2015-2021
Gannan Medical University
2021
First Affiliated Hospital of Gannan Medical University
2021
First Affiliated Hospital of Bengbu Medical College
2020
Xiangnan University
2019
Small nucleolus RNA Host Gene 8 (SNHG8) belongs to a subgroup with long non-coding RNAs. LncRNA SNHG8 presents up-regulated in miscellaneous cancers, like gastric cancer, liver and esophageal squamous cell cancer. Nevertheless, the expression pattern pathological function of lncRNA breast cancer remain obscure.We examined levels tissue samples lines from via RT-qPCR present study. The functions on progression were by CCK-8, EdU, Transwell chamber assays, flow cytometry analyses. proteins was...
Background: Reineckia carnea is commonly used to treat cough, pneumonia and other diseases in China. In our previous study, it was found that the ethanol extracts of have a strong inhibitory effect on proliferation human lung cancer A549 cells. Here, we isolated gracillin from for first time. Purpose: Clarify antiproliferation cells further explore its mechanisms via mitochondrial pathway. Methods: Gracillin purified by silica gel, D-101 macroporous resin preparative RP-HPLC, then identified...
This research planned to grab the expression and impact of lncRNA HAGLROS in biology progression mantle cell lymphoma. level lymphoma lines was detected, followed by investigation influences silencing on Mino biological performances. Afterwards, express patterns vs. miR-100, as well miR-100 ATG5, were investigated. Furthermore, whether could regulate signals PI3K/AKT/mTOR analyzed. high lines. Silencing inhibited viability, increased apoptosis decreased autophagy sponging miR-100. Moreover,...
Multiple studies have demonstrated chemoresistance in multiple types of tumor, which limits the effectiveness cancer treatments. Chemoresistance often contributes to relapse. Non‑coding RNAs, are a group regulatory that involved tumor drug resistance. Exosomes, membranous vesicles secreted by cells, reported mediate cell‑to‑cell communication, including cancer. Furthermore, exosomal non‑coding RNAs been via exchange biological information. In present review, main roles micro(mi) long (lnc)...
Aberrant activation of the hedgehog (Hh) signaling pathway has shown predictive significance for treatment response and prognostic effect survival in human tumors. However, associations Hh with to neoadjuvant therapy (NAT) after NAT breast cancer are unknown. Therefore, we investigated correlation pretherapeutic nuclear expression glioma-associated oncogene homolog 1 (Gli1), a key transcriptional factor pathway, pathological complete (pCR) event-free (EFS) HER2-positive treated...
This work is designed to probe the functions and mechanisms of circ_0000518 in breast cancer (BC). qRT-PCR was performed evaluate circ_0000518, miR-1225-3p Sry‑Related HMG box 4 (SOX4) mRNA expression BC tissues cells. After overexpressed MDA-MB-468 cells, knocked down BT549 CCK-8 test, EdU assay were measure viability growth Wound healing experiment executed determine migration The invasion cells studied by Transwell assay. Bioinformatics analysis, dual-luciferase reporter gene assay,...
Background: Some studies have found that the application of traditional Chinese medicine in treatment lung cancer has achieved satisfying results. Polyphyllin Ⅲ (PP Ⅲ) is a natural steroid saponin from P. polyphylla var. yunnanensis, and its analogs played wide role anticancer research. This study aimed to investigate effect PP on development molecular mechanism. Methods: A549 NCI-H1299 cell lines were treated with gradient concentration detect IC50 cells, optimal was selected for subsequent...