A5102854631- Urban Transport and Accessibility
- Transportation Planning and Optimization
- Smart Parking Systems Research
- Microtubule and mitosis dynamics
- Cellular transport and secretion
- Transportation and Mobility Innovations
- Sharing Economy and Platforms
- Energy, Environment, and Transportation Policies
- Economic and Environmental Valuation
- Traffic and Road Safety
- Agriculture and Farm Safety
- Cellular Mechanics and Interactions
- Airway Management and Intubation Techniques
- Cell Image Analysis Techniques
- Cell Adhesion Molecules Research
- Mitochondrial Function and Pathology
- Tracheal and airway disorders
- Advanced Vision and Imaging
- Advanced Measurement and Detection Methods
- Wnt/β-catenin signaling in development and cancer
- Autonomous Vehicle Technology and Safety
- Caveolin-1 and cellular processes
- Advanced Adaptive Filtering Techniques
- Transportation Safety and Impact Analysis
- Safety Warnings and Signage
Hong Kong Polytechnic University
2024
National University of Singapore
1986-2024
University of British Columbia
2016-2022
McMaster University
1993-2021
London School of Economics and Political Science
2021
Beth Israel Deaconess Medical Center
2016-2019
California Polytechnic State University
2019
Harvard University
2016-2018
University of California, Irvine
2014-2018
University of California, Davis
2018
Abstract Background Many eukaryotic genomes encode cis -natural antisense transcripts ( -NATs). Sense and may form double-stranded RNAs that are processed by the RNA interference machinery into small interfering (siRNAs). A few so-called nat-siRNAs have been reported in plants, mammals, Drosophila , yeasts. However, many questions remain regarding features biogenesis of nat-siRNAs. Results Through deep sequencing, we identified more than 17,000 unique siRNAs corresponding to -NATs from...
Actin-associated proteins regulate multiple cellular processes, including proliferation and differentiation, but the molecular mechanisms underlying these processes are unclear. Here, we report that actin-binding protein filamin A (FlnA) physically interacts with actin-nucleating formin 2 (Fmn2). Loss of FlnA Fmn2 impairs proliferation, thereby generating embryonic phenotypes, microcephaly. Wnt co-receptor Lrp6. Lrp6 endocytosis, downstream Gsk3β activity, β-catenin accumulation in nucleus....
Filamins are a family of actin-binding proteins responsible for diverse biological functions in the context regulating actin dynamics and vesicle trafficking. Disruption these has been implicated multiple human developmental disorders. To investigate roles different filamin isoforms, we focused on FlnA FlnB interactions cartilage growth plate, since mutations both molecules cause chondrodysplasias. Current studies show that share common function stabilizing cytoskeleton, they physically...
This paper reports our work on building up a Cantonese Speech-to-Text (STT) system with syllable based acoustic model. is part of an effort in STT to aid dyslexic students who have cognitive deficiency writing skills but no problem expressing their ideas through speech. For speech recognition, the basic unit models can either be conventional Initial-Final (IF) syllables, or Onset-Nucleus-Coda (ONC) syllables where finals are further split into nucleus and coda reflect intra-syllable...
Abstract Neural progenitor proliferation and cell fate decision from self-renewal to differentiation are crucial factors in determining brain size morphology. The cytoskeletal dependent regulation of these processes is not entirely known. actin-binding filamin A (FlnA) was shown regulate progenitors by directing changes cycles proteins such as Cdk1 during G2/M phase. Here we report that functional loss FlnA only affects the rate altering cycle length but also causes a defect early through...
The effects of actin dependent molecular mechanisms in coordinating cellular proliferation, migration and differentiation during embryogenesis are not well-understood. We have previously shown that actin-binding Filamin A (FlnA) actin-nucleating Formin 2 (Fmn2) influence the development brain causing microcephaly mice. In this study, we broaden phenotype to explore these two proteins extra-CNS organ systems, including gut, muscle, skeleton. observed defects rib sternum midline closure...
Identification of small objects in fluorescence microscopy is a non-trivial task burdened by parameter-sensitive algorithms, for which there clear need an approach that adapts dynamically to changing imaging conditions. Here, we introduce adaptive object detection method that, given image and level label, uses kurtosis-based matching the distribution differential express operator intent terms recall or precision. We show how theoretical upper bound statistical distance feature space enables...
A novel method of implementing FIR (finite impulse response) adaptive filters using the discrete Hartley transform (DHT) and overlap-save is proposed. It not only has advantage fast convergence for highly correlated input signals, but also provides a significant reduction in computation over conventional time-domain frequency-domain least mean square (LMS) filters. Compared with previously proposed unconstrained FLMS algorithm, performance similar, an approximate saving 30% can be obtained...
The authors apply the radial basis function (RBF) neural network to low-angle radar tracking. Computer simulations show that RBF is capable of tracking both stationary and moving targets with high accuracy. As well, performance evaluated under different signal-to-noise ratio situations. Furthermore, real-life data are used test network. results demonstrate robustness effectiveness in terms its independence array errors nature noise background.
Actin-associated proteins regulate multiple cellular processes, including proliferation and differentiation, but the molecular mechanisms underlying these processes are unclear. Here, we report that actin-binding protein filamin A (FlnA) physically interacts with actin-nucleating formin 2 (Fmn2). Loss of FlnA Fmn2 impairs proliferation, thereby generating embryonic phenotypes, microcephaly. Wnt co-receptor Lrp6. Lrp6 endocytosis, downstream Gsk3β activity, β-catenin accumulation in nucleus....
Observation chez une femme de 25 ans d'une peste tubonique dans region d'endemie. Traitement a base gentamicine et d'ampicilline
The authors incorporate experiential learning into three courses: Urban Economics, Labor and the Economics of Inequality. Students visit neighborhoods that, while geographically proximate, remain outside most students’ day-to-day experiences, such as a legal red-light district that is also home to low-wage immigrant workers public rental housing estate whose residents were recently relocated. These location-oriented field trips raise confluence themes, poverty crime, relate beyond authors’...
<title>Abstract</title> Do citizens value electrification of public transport? Consumer theory predicts that cleaner and quieter services will attract commuters to electric buses as these displace conventional diesel. This response has not been tested, despite the vast investment planned by local governments school districts worldwide they decarbonize tackle air pollution traffic gridlock. Here we provide a three-pronged analysis empirical demand bus electrification. First, ridership...