A5014251306- Neuroendocrine regulation and behavior
- Neural and Behavioral Psychology Studies
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Evolutionary Game Theory and Cooperation
- Advanced Fluorescence Microscopy Techniques
- CCD and CMOS Imaging Sensors
- Evolutionary Psychology and Human Behavior
- Photoreceptor and optogenetics research
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Functional Brain Connectivity Studies
- Circadian rhythm and melatonin
- Optical Imaging and Spectroscopy Techniques
- Receptor Mechanisms and Signaling
- Advanced Memory and Neural Computing
- Online and Blended Learning
- Neuroscience and Neural Engineering
- Gender and Technology in Education
- Substance Abuse Treatment and Outcomes
- Library Science and Information Literacy
- Cannabis and Cannabinoid Research
University of Colorado Boulder
2022-2024
University of Washington
2024
Weatherford College
2023
National Institute on Drug Abuse
2019-2022
National Institutes of Health
2020-2022
Boston College
2017-2018
Background Studies using continuous-access drug self-administration showed that cocaine seeking increases during abstinence (incubation of craving). Recently, studies intermittent-access increased motivation to self-administer and seek cocaine. We examined whether intermittent would potentiate incubation craving in male female rats the estrous cycle's role this incubation. Methods In experiment 1, self-administered either continuously (8 hours/day) or intermittently (5 minutes ON, 25 OFF ×...
The prefrontal cortex is involved in goal-directed behavior. Here, we investigate circuits of the PFC regulating motivation, reinforcement, and its relationship to dopamine neuron activity. Stimulation medial (mPFC) neurons mice activated many downstream regions, as shown by fMRI. Axonal terminal stimulation mPFC including anteromedial thalamic nucleus (AM), reinforced behavior midbrain dopaminergic neurons. AM projecting also neurons, showed a positive-feedback loop organization. We found...
Social animals detect the affective states of others and utilize this information to orchestrate appropriate social interactions. behaviors include cooperation, reproductive acts avoiding sick individuals. In a behavioral test in which experimental adult male rats were given choice interact with either naive or stressed conspecifics, demonstrated both approach avoidant towards conspecific, depending upon age conspecific; approached juvenile but avoided adult. Optogenetic inhibition insular...
Photometry approaches detect sensor-mediated changes in fluorescence as a proxy for rapid molecular within the brain. As flexible technique with relatively low cost to implement, photometry is rapidly being incorporated into neuroscience laboratories. Yet, although multiple data acquisition systems now exist, robust analytical pipelines resulting remain limited. Here we present Analysis Toolkit (PhAT)-a free open-source analysis pipeline that provides options signal normalization,...
Photometry approaches detect sensor-mediated changes in fluorescence as a proxy for rapid molecular within the brain. As flexible technique with relatively low cost to implement, photometry is rapidly being incorporated into neuroscience laboratories. While multiple data acquisition systems now exist, robust analytical pipelines resulting remain limited. Here we present Ph otometry A nalysis T oolkit (PhAT) - free open source analysis pipeline that provides options signal normalization,...
ABSTRACT In monogamous species, prosocial behaviors directed towards partners are dramatically different from those unknown individuals and potential threats. Dopamine release in the nucleus accumbens plays an important role guiding social behavior, however, its real time decision making a species remains largely unknown. We used prairie voles to investigate how dopamine differs when seeking interacting with pair bonded partner or novel vole. Employing sub-second temporal resolution of...
Abstract Background Computational models that predict effects of neural stimulation can be used as a preliminary tool to inform in-vivo research, reducing the costs, time, and ethical considerations involved. However, current do not support diverse techniques , including expanding selection electrodes, modalities, paradigms. New Method To develop more comprehensive software, we created several extensions The Virtual Electrode Recording Tool for EXtracellular Potentials (VERTEX), MATLAB-based...
Abstract How does the prefrontal cortex (PFC) regulate motivated behavior? Our experiments characterize circuits of PFC regulating motivation, reinforcement and dopamine activity, revealing a novel cortico-thalamic loop. The stimulation medial (mPFC) neurons activated many downstream regions, as shown by functional MRI. Axonal terminal mPFC in including anteromedial thalamic nucleus (AM), reinforced behavior midbrain dopaminergic neurons. AM projecting to also neurons, showed...
In monogamous species, prosocial behaviors directed towards partners are dramatically different from those unknown individuals and potential threats. Dopamine release in the nucleus accumbens plays an important role guiding social behavior, however, its real-time motivation decision making a species remains largely unknown. We used prairie voles to investigate how dopamine differs when seeking interacting with pair bonded partner or novel vole operant task. Within this context, we found that...