A5011063082- Renal Diseases and Glomerulopathies
- Vasculitis and related conditions
- Pulmonary Hypertension Research and Treatments
- Systemic Sclerosis and Related Diseases
- Biomedical Research and Pathophysiology
- Renal and Vascular Pathologies
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Muscle Physiology and Disorders
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Adipose Tissue and Metabolism
- Mitochondrial Function and Pathology
- Protein Kinase Regulation and GTPase Signaling
- Cell death mechanisms and regulation
- Chronic Kidney Disease and Diabetes
- Platelet Disorders and Treatments
- Genetic and Kidney Cyst Diseases
- Skin Diseases and Diabetes
- Nutrition and Health in Aging
- PI3K/AKT/mTOR signaling in cancer
- Tuberous Sclerosis Complex Research
- Inflammasome and immune disorders
- Cardiomyopathy and Myosin Studies
Institut de Pharmacologie Moléculaire et Cellulaire
2019-2024
Centre National de la Recherche Scientifique
2021-2024
Université Côte d'Azur
2019
University of Aveiro
2012-2016
Universidade do Porto
2013
A cyclical corticosteroid-cyclophosphamide regimen is recommended for patients with primary membranous nephropathy at high risk of progression. We hypothesized that sequential therapy tacrolimus and rituximab superior to alternating treatment corticosteroids cyclophosphamide in inducing persistent remission these patients. This was tested a randomized, open-label controlled trial 86 nephrotic syndrome after six-months observation assigned 43 each receive six-month corticosteroid or...
Personalized treatment for patients with membranous nephropathy requires accurate prediction of the disease course at an early stage. In this study, we evaluated value baseline anti-phospholipase A2 receptor (PLA2R1) antibody titer as a prognostic biomarker in PLA2R1-associated nephropathy.In cohort included 168 (118 men, 50 women) referred to our nephrology center between February 1995 and November 2016. Mean age was 52 ± 13 years. There were 156 new-onset 12 relapse (n = 10) or recent use...
Background and objectives Patients with membranous nephropathy can have circulating autoantibodies against membrane-bound (phospholipase A2 receptor 1 [PLA2R1] thrombospondin type-1 domain containing 7A [THSD7A]) intracellular (aldose reductase, SOD2, α-enolase) podocyte autoantigens. We studied their combined association clinical outcomes. Design, setting, participants, & measurements Serum levels of anti-PLA2R1, anti-THSD7A, anti-aldose anti-SOD2, anti−α-enolase were determined in 285...
Pulmonary arterial hypertension (PAH) is a progressive disease with poor prognosis. artery smooth muscle cells (PASMCs) play crucial role in PAH pathophysiology, displaying hyperproliferative, and apoptotic-resistant phenotype. In the present study, we evaluated potential therapeutic of terameprocol (TMP), an inhibitor cellular proliferation promoter apoptosis, well-established pre-clinical model induced by monocrotaline (MCT) studied biological pathways modulated TMP PASMCs. Wistar rats...
Cardiac cachexia is characterized by an imbalance between anabolic and catabolic factors that lead to weight loss. The present study addresses the preventive effect of exercise training on muscle wasting in animal model right ventricular failure induced monocrotaline (MCT) administration. After 4 weeks or cage living, male Wistar rats were injected with MCT (60mg/kg) (ExMCT SedMCT, respectively) saline (ExC SedC, respectively), sacrificed after additional 4week‐period movement confined...
Purpose: Cachexia is one of the most debilitating and life-threatening aspects pulmonary arterial hypertension. The involvement mitochondrial in muscle wasting underlying PAH-induced weight loss poorly known. In present work, contribution mitochondria plasticity through analysis gastrocnemius was evaluated. Methods: Animal experiments were performed according to Portuguese law on animal welfare conform Guide for Care Use Laboratory Animals published by US National Institutes Health (NIH...