A5037930283- Endoplasmic Reticulum Stress and Disease
- Monoclonal and Polyclonal Antibodies Research
- Blood properties and coagulation
- Galectins and Cancer Biology
- Celiac Disease Research and Management
- Microbial Inactivation Methods
- Diet and metabolism studies
- Metabolism and Genetic Disorders
- Mitochondrial Function and Pathology
- Erythrocyte Function and Pathophysiology
- Adipokines, Inflammation, and Metabolic Diseases
Stanford University
2018-2022
Celiac disease (CeD) is an autoimmune disorder induced by consuming gluten proteins from wheat, barley, and rye. Glutens resist gastrointestinal proteolysis, resulting in peptides that elicit inflammation patients with CeD. Despite well-established connections between glutens CeD, chemically defined, bioavailable produced dietary have never been identified humans unbiased manner. This largely attributable to technical challenges, impeding our knowledge of potentially diverse peptide species...
Significance Macrophages are important regulators of the immune system. They display remarkable phenotypic plasticity in response to environmental cues. Classical macrophage activation occurs inflammatory signals, whereas alternative results from exposure IL-4 and/or IL-13. The mechanistic basis for differential regulation macrophages by and IL-13 remains poorly understood. We show through vitro vivo experiments that thioredoxin 1, a redox protein cofactor, preferentially inactivates over...
ABSTRACT Celiac disease (CeD) is an autoimmune disorder induced by consuming gluten proteins from wheat, barley, and rye. Glutens resist gastrointestinal proteolysis, resulting in peptides that elicit inflammation patients with CeD. Despite well-established connections between glutens CeD, chemically defined, bioavailable produced dietary have never been identified humans unbiased manner. This largely attributable to technical challenges, impeding our knowledge of potentially diverse peptide...