A5004271845- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Metabolism and Genetic Disorders
- Liver Disease Diagnosis and Treatment
- Metabolism, Diabetes, and Cancer
- Nitric Oxide and Endothelin Effects
- Electrolyte and hormonal disorders
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Disease and Adiposity
- Lipid metabolism and disorders
- Birth, Development, and Health
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Regulation of Appetite and Obesity
- Eicosanoids and Hypertension Pharmacology
- Mitochondrial Function and Pathology
- Muscle metabolism and nutrition
- Hormonal Regulation and Hypertension
- Clinical Nutrition and Gastroenterology
- Nutrition, Genetics, and Disease
- Natural Antidiabetic Agents Studies
- Fatty Acid Research and Health
- Iron Metabolism and Disorders
- Gestational Diabetes Research and Management
Institute of Clinical and Experimental Medicine
1999-2024
The role of folate deficiency and associated hyperhomocysteinemia in the pathogenesis metabolic syndrome is not fully established. In current study, we analyzed spontaneously hypertensive rat (SHR). Metabolic hemodynamic traits were assessed SHR/Ola rats fed either folate-deficient or control diet for 4 weeks starting at age 3 months. Compared to SHRs a folate-replete diet, showed significantly reduced serum (104±5 vs. 11±1 nmol/L, P < 0.0005) urinary excretion (4.3±0.6 1.2±0.1 nmol/16h,...
Disorders of carbohydrate and lipid metabolism have been reported to cluster in patients with essential hypertension spontaneously hypertensive rats (SHRs). A deletion the Cd36 gene on chromosome 4 has recently implicated defective isolated adipocytes from SHRs. However, role control blood pressure systemic cardiovascular risk factors SHRs is unknown. In SHR.BN-Il6/Npy congenic strain, we found that transfer a segment (including Cd36) Brown Norway (BN) rat onto SHR background induces...
In this study, we focused on an analysis of biguanides effects mitochondrial enzyme activities, membrane potential and permeability transition pore function. We used phenformin, which is more efficient than metformin, evaluated its effect rat liver mitochondria isolated hepatocytes. contrast to previously published data, found that after a 5 min pre-incubation, dose-dependently inhibits not only complex I but also II IV activity in mitochondria. The enzymes complexes inhibition paralleled by...
Spontaneously hypertensive rats (SHR/NIH strain) harbor a deletion variant in the Cd36 fatty acid transporter and display defective metabolism, insulin resistance hypertension. Transgenic rescue of SHR ameliorates improves dyslipidemia. However, role blood pressure regulation remains controversial due to inconsistent effects that were observed with transgenic expression on background. In current studies, we developed two new lines, which express wild type under control universal Ef-1 alpha...
The potential insulin-sensitizing function of angiotensin II type 1 receptor blockade (ARB) with regard to selected adipokines is not fully explained so far. Our study aimed explore the influence acute hyperinsulinaemia and acutely induced ARB on resistin adiponectin concentrations expressions in healthy subjects.Plasma were measured: 1) at 0, 30 240 min hyperinsulinaemic (1 mU/kg per min) euglycaemic (5 mmol/l) clamp (HEC), 2) during HEC after (losartan 200 mg; AT-HEC) using same protocol,...
Abstract While phosphodiesterase‐5 inhibition (PED5i) may prevent hypertrophy and failure in pressure‐overloaded heart an experimental model, the impact of PDE5i on volume‐overload (VO)‐induced is unknown. It also unclear whether hypertrophied right ventricle (RV) left (LV) differ their responsiveness to long‐term if this therapy affects renal function. The goal study was elucidate effect treatment VO due aorto‐caval fistula (ACF) compare with standard (HF) angiotensin‐converting enzyme...
The aim of the study was to determine contribution skeletal muscle, adipose tissue and liver impaired glucose clearance manifesting itself during initial phase OGTT in a non-obese animal model insulin resistance, hereditary hypertriglyceridemic (HHTg) rats. Glucose utilisation storage target tissues vivo vitro after load (3 g/kg b. wt.) administered intragastrically following overnight fasting compared adult male HHTg rats Wistar normotriglyceridemic controls short-term (2 wk) high-sucrose...
The abnormal proliferation of vascular smooth muscle cells (VSMC) is thought to play a role in the pathogenesis atherosclerosis. Adipocytes produce several bioactive paracrine substances that can affect growth and migration VSMCs. Our study focuses on direct effect conditioned media (CM) was obtained by incubation with primary adipocyte-derived cell lines, including lines derived from both preadipocytes more mature cells, rate human aortic (HAoSMCs). We used Luminex assay measure adipokine...
Our aim was to assess the reaction of TNFα, resistin, leptin and adiponectin lipid infusion. Eight healthy subjects underwent a 24-hour lasting infusion emulsion. Plasma concentrations expressions selected cytokines in subcutaneous fat were measured. TNFα plasma concentration did not change during first 4 hours hypertriglyceridemia, but significant increase after 24 detected (p<0.001 for 0; 30; 240 min vs. h). resistin significantly increased at 30 remained elevated (p<0.01 0 min;...