Lei Gao

ORCID: 0000-0003-1650-8960
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About
Contact & Profiles
Research Areas
  • Circadian rhythm and melatonin
  • Genetics, Aging, and Longevity in Model Organisms
  • Dietary Effects on Health
  • Coronary Interventions and Diagnostics
  • Sperm and Testicular Function
  • Estrogen and related hormone effects
  • Psychological and Temporal Perspectives Research
  • Immune Cell Function and Interaction
  • Coronary Artery Anomalies
  • Nuclear Receptors and Signaling
  • Sleep and Wakefulness Research
  • Acute Myocardial Infarction Research
  • Autophagy in Disease and Therapy
  • Peripheral Artery Disease Management
  • Railway Systems and Energy Efficiency
  • Endoplasmic Reticulum Stress and Disease
  • Effects and risks of endocrine disrupting chemicals
  • Diet, Metabolism, and Disease
  • High Altitude and Hypoxia
  • Advanced MIMO Systems Optimization
  • Cardiovascular Issues in Pregnancy
  • Cerebrovascular and Carotid Artery Diseases
  • Hormonal Regulation and Hypertension
  • Diet and metabolism studies
  • Kawasaki Disease and Coronary Complications

Ministry of Agriculture and Rural Affairs
2022-2023

Northwest A&F University
2016-2023

Qinghai University
2022

Ministry of Agriculture, Livestock, and Food Supply
2016-2021

Chinese PLA General Hospital
2009-2019

ELOVL3 is a very long-chain fatty acid elongase, and its mRNA levels display diurnal rhythmic changes exclusively in adult male mouse livers. This cyclical expression of hepatic Elovl3 potentially controlled by the circadian clock, related hormones, transcriptional factors. It remains unknown, however, whether conjunction with androgen signaling, functions maintaining sexually dimorphic manner. Under either zeitgeber or time, WT livers exhibited robust rhythmicity clock genes In contrast,...

10.1074/jbc.ra118.005950 article EN cc-by Journal of Biological Chemistry 2019-03-12

Abstract Testosterone is produced by Leydig cells (LCs) and undergoes diurnal changes in serum levels rats, mice, humans, but little known goats. The present study revealed that goat testosterone displayed rhythmic (peak time at ZT11.2). Immunohistochemical staining showed BMAL1, a circadian clock protein, highly expressed LCs. ELISA both hCG (0–5 IU/ml) 22R‐OH‐cholesterol (0–30 μM) addition stimulated synthesis primary LCs dose‐dependent manner. Treating with (5 significantly increased...

10.1002/jcp.30334 article EN Journal of Cellular Physiology 2021-02-17

New-generation drug-eluting stents (DES) was more effective in the treatment of in-stent restenosis (ISR) compared with first-generation DES. Drug-eluting balloons (DEB) and new-generation DES had been available strategies bare-metal stents/DES ISR (BMS/DES-ISR). Six new randomized trials have recently examined angiographic outcomes one-year clinical DEB generation BMS/DES-ISR. However, optimal management for BMS/DES-ISR lesions remains controversial.We searched evaluating patients The...

10.11909/j.issn.1671-5411.2019.06.002 article EN PubMed 2019-06-01

Background: This study aimed to investigate whether there were sex differences in in-hospital and long-term outcomes for elderly patients over 75 years of age undergoing percutaneous coronary intervention heart disease. Methods: Consecutive aged ≥75 who underwent at a single center the People’s Republic China from January 2005 December 2010 included this cohort study. Clinical characteristics compared between men women. Results: A total 465 (34.8% women, mean 78.5±3.2 years) recruited. Men...

10.2147/cia.s62643 article EN cc-by-nc Clinical Interventions in Aging 2014-10-01

A stent in a false lumen is common cause of occlusion after coronary percutaneous artery intervention therapy, particularly the culprit lesion acute myocardial infarction. Here, we present an unusual case successful recanalization proximal right with implementation another to crush previous lumen.A 40-year-old Chinese man underwent due inferior wall infarction at hospital. Six months later, he angiography re-examination for recurrent symptomatic angina our Coronary and intravascular...

10.1186/s13256-018-1897-3 article EN cc-by Journal of Medical Case Reports 2018-12-01

A resource allocation strategy based on the improved Marine Predators Algorithm and KM algorithm is proposed to address interference problem generated by spectrum multiplex in coexistence scenario of Train (T2T) communication Ground (T2G) urban rail transit system while ensuring user quality. First, throughput optimization model under multiple constraints developed decomposed into two sub-problems optimal power Channel Multiplex matching. Second, considering problems premature convergence...

10.1117/12.3004081 article EN 2023-10-11
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