A5015109469- Thyroid Disorders and Treatments
- Diet and metabolism studies
- Diabetes and associated disorders
- Cardiovascular and exercise physiology
- Eating Disorders and Behaviors
- Nutritional Studies and Diet
- Heart Rate Variability and Autonomic Control
- Thyroid Cancer Diagnosis and Treatment
- Physical Activity and Health
- Gut microbiota and health
- Pancreatic function and diabetes
- Nutrition and Health in Aging
- Ion channel regulation and function
- Pituitary Gland Disorders and Treatments
- Diabetes Management and Research
- COVID-19 and Mental Health
- Dietary Effects on Health
- Bipolar Disorder and Treatment
- Genetics and Neurodevelopmental Disorders
- Obesity, Physical Activity, Diet
- Body Composition Measurement Techniques
- Sleep and related disorders
- Health and Lifestyle Studies
- Stroke Rehabilitation and Recovery
- Microscopic Colitis
University of Cagliari
2016-2025
Azienda Ospedaliero-Universitaria Cagliari
2021-2023
Presidio Ospedaliero
2022
Nuovo Ospedale San Giovanni di Dio
2021
University of Pisa
1991-1994
Abstract In the present study, we characterized distinctive signatures of gut microbiota (GM) from overweight/obese patients (OB), and normal-weight controls (NW), both Sardinian origin. Fecal bacterial composition 46 OB (BMI = 36.6 ± 6.0; F/M 40/6) was analyzed compared to that NW subjects 21.6 2.1; 41/5), matched for sex, age smoking status, by using 16S rRNA gene sequencing on MiSeq Illumina platform. The microbial community exhibited a significant decrease in relative abundance several...
This study was aimed at characterizing the gut microbiota (GM) and its functional profile in two groups of Sardinian subjects with a long healthy life expectancy, overall named Long-Lived Subjects (LLS) [17 centenarians (CENT) 29 nonagenarians (NON)] by comparing them to 46 younger controls (CTLs). In addition, contribution genetics environmental factors GM phenotype assessed subgroup seven centenarian parents (CPAR) paired cohort centenarians' offspring (COFF). The analysis performed...
Background/Objectives: Managing type 2 diabetes mellitus (T2DM) and obesity requires a multidimensional, patient-centered approach including nutritional interventions (NIs) physical activity. Changes in the gut microbiota (GM) have been linked to metabolic alterations typical of T2DM obesity, they are strongly influenced by diet. However, few studies evaluated effects on GM very-low-calorie ketogenic diet (VLCKD) patients with T2DM, especially mid-term long-term. This longitudinal study is...
Physical activity in the elderly is recommended by international guidelines to protect against cognitive decline and functional impairment.This Randomized Controlled Trial (RCT) was set up verify whether medium-intensity physical people living community effective improving performance.RCT with parallel balanced large groups.Academic university hospital Olympic gyms.People aged 65 years old older of both genders at home holding a medical certificate for suitability non-competitive...
Smell plays a critical role in food choice and intake by influencing energy balance body weight. Malnutrition problems or modified eating behaviors have been associated with olfactory impairment loss. The obesity epidemic is serious health problem an increased risk of mortality major physical comorbidities. etiopathogenesis complex multifactorial, one the main factors contributing to rapid increase its incidence environment which we live, encourages overconsumption foods rich energy, such as...
Type 2 diabetes mellitus (T2DM), the most common form of diabetes, is a progressive chronic metabolic disease that has increasingly spread worldwide, enhancing mortality rate, particularly from cardiovascular diseases (CVD). Lifestyle improvement through diet and physical activity is, together with drug treatment, cornerstone T2DM management. The Mediterranean (MD), which favors prevalence unprocessed vegetable foods reduction in red meats industrial foods, without excluding any food...
Thyroid function was evaluated in 150 Sardinian outpatients at different stages of lithium treatment. A visible and/or palpable goitre found 51% patients, and there no apparent correlation with the duration No cases symptomatic hypothyroidism were observed, but subclinical present 19% patients. The prevalence specific antithyroid antibodies positively correlated age treatment, higher women. Subclinical observed 53% antibody-positive lithium-treated Carbamazepine combination associated...
Although it is known that the gut microbiota (GM) can be modulated by diet, efficacy of specific dietary interventions in determining its composition and diversity obese patients remains to ascertained. The present work aims evaluate impact a moderately hypocaloric Mediterranean diet on GM overweight (OB). 23 OB (F/M = 20/3) was compared before (T0) after 3 months (T3) nutritional intervention (NI). Fecal samples were analyzed Illumina MiSeq sequencing 16S rRNA gene. At baseline,...
Abstract Background Aging is marked by a progressive rise in chronic diseases with an impact on social and healthcare costs. Physical activity (PA) may soothe the inconveniences related to diseases, has positive effects quality of life biological rhythms, can prevent decline motor functions consequent falls, which are associated early death disability older adults. Methods We randomized 120 over-65 males females into groups similar size timing will give each either moderate physical or...
The relationship among iodine intake, goiter prevalence, and thyroid autoimmunity remains controversial. In the present article, we report prevalence of antithyroid antibodies (ATA) in relation to frequency goiter, function a large group Sardinian schoolchildren living areas with borderline sufficiency, or mild moderate deficiency. A total 8,040 (4,194 males, 3,846 females, ages 6-15 years) from 29 communities were examined between 1986-1994. Thyroid size was assessed by palpation, according...
Functioning of Social Behavioral Rhythms (SBRs) may affect resilience toward stressful events across different age groups. However, the impact SBRs on coronavirus disease 2019 (COVID-19) in elder people is yet to ascertain, representing aim present report.Follow-up a peer-reviewed randomized controlled trial exercise old adults (³65 years), concurrent onset pandemic-related lockdown. Post-RCT evaluations occurred after further 12 and 36 weeks since beginning lockdown phase. People with Major...
Obesity is a severe health problem linked to an increased risk of comorbidity and mortality its etiopathogenesis includes genetic, epigenetic, microbiota composition, environmental factors, such as dietary habits. The olfactory system plays important role in controlling food intake meal size, influencing body weight energy balance. This study aims identify the connection between function clinical nutritional aspects related excess group 68 patients with overweight or obesity. All...
We sought to reevaluate the prevalence of thyroid dysfunction and autoimmunity in 47 patients with celiac disease; 91 healthy subjects were studied as controls. Both controls from Sardinia, Italy.Diagnosis disease was made on basis clinical history, presence positive antigliadin IgA (AGA-A) IgG (AGA-G) antibodies, antireticulin antibodies (ARA), antiendomysium (EMA), confirmed by jejunal biopsy. HLA class II typing for DQB1 DQA1 alleles performed 36/47 patients. Thyroid evaluated palpation...
TSH secretion was evaluated in 10 patients with ACTH-dependent (pituitary microadenoma, n = 5) or ACTH-independent [adrenal adenoma (n 4) carcinoma 1)] Cushing's syndrome, and 12 normal controls matched for age sex. Serum concentration assayed at night, from 2200–0200 h, the morning, both basally 30 min after iv injection of 200 μg synthetic TRH. Patients hypercortisolism showed significantly reduced serum total T4 T3 free concentrations increased reverse levels. Their mean baseline albeit...
A total of 116 patients on lithium treatment were followed up for 2 years to determine the course and clinical relevance thyroid abnormalities. Elevated thyroid‐stimulating hormone (TSH) concentrations transitory in most patients, except those with serum antithyroid antibodies. The who initially had microsomal antibodies remained positive, an increase titre two‐thirds cases. Three young both sexes developed autoimmunity early treatment. risk developing hypothyroidism was higher women,...