A5037524730- Thyroid Disorders and Treatments
- Pituitary Gland Disorders and Treatments
- Growth Hormone and Insulin-like Growth Factors
- Thyroid Cancer Diagnosis and Treatment
- Ion channel regulation and function
- History of Medicine Studies
- Adrenal and Paraganglionic Tumors
- Empathy and Medical Education
- Adrenal Hormones and Disorders
- Cancer, Hypoxia, and Metabolism
- Renaissance and Early Modern Studies
- Neuroendocrine Tumor Research Advances
- Diabetes and associated disorders
- Ophthalmology and Eye Disorders
- Cardiac electrophysiology and arrhythmias
- Ancient Mediterranean Archaeology and History
- Neuroscience and Neuropharmacology Research
- Genetic factors in colorectal cancer
- Retinoids in leukemia and cellular processes
- Reformation and Early Modern Christianity
- Glaucoma and retinal disorders
- Neurology and Historical Studies
- Thyroid and Parathyroid Surgery
- Neonatal Health and Biochemistry
- Monoclonal and Polyclonal Antibodies Research
European Institute of Oncology
2024-2025
University of Campania "Luigi Vanvitelli"
2024
Deakin University
2024
University of Pisa
2012-2023
Ospedale Cisanello
2001-2016
National Research Council
2013
Marqués de Valdecilla University Hospital
2002
Universidad de Cantabria
2002
University of Cagliari
1987-1992
University of Massachusetts Chan Medical School
1986-1987
The aim of the present study was to establish usefulness conventional thyroid ultrasonography (US) and color flow-doppler (CFD) sonography in assessment 'cold' nodules. One hundred four consecutive patients with nodules who were undergo surgery examined by US CFD before thyroidectomy. Conventional evaluated presence a halo sign, hypoechogenicity microcalcifications. vascular pattern on classified as follows: Type I, absence blood flow; II, perinodular III, marked intranodular flow. On...
Amiodarone-induced thyrotoxicosis (AIT) occurs in both abnormal (type I) and apparently normal II) thyroid glands due to iodine-induced excessive hormone synthesis patients with nodular goiter or latent Graves' disease a thyroid-destructive process caused by amiodarone iodine II). Twenty-four consecutive AIT patients, 12 type I II, were evaluated prospectively. Sex, age, severity of thyrotoxicosis, cumulative dose similar. Type II had higher serum interleukin-6 (IL-6; median, 440 vs. 173...
Serial tests for long-acting thyroid stimulator (LATS) and antithyroglobulin antibodies were performed in 32 patients with toxic diffuse goiter submitted to 131I therapy 29 receiving antithyroid drugs. The level of detectable LATS the incidence positive assays tended increase transiently following decrease during administration Statistical analysis changes detected at time interval 46–180 days after treatment showed that differences between 2 therapeutic groups significant. A transient rise...
Thyroid ultrasound was used to measure thyroid volume in children and compared with palpation for the assessment of prevalence goiter an area mild iodine deficiency. School children, 6-14 yr old, were from control areas (n = 2693; urinary excretion, 110 micrograms/L) or deficiency (IDA; n 278; 72 micrograms/L). determined by increased age (r 0.62; P < 0.0001) significantly correlated height 0.51; body weight 0.126; 0.0001). Both median mean volumes greater IDA than controls. The 68 268...
Germline point mutations in exons 10, 11, and 16 of the ret protooncogene have been identified as causative multiple endocrine neoplasia type 2 familial medullary thyroid carcinoma (MTC). Somatic same gene, exclusively associated with codon 918 exon 16, also reported few cases sporadic carcinoma. We analyzed blood tumor DNA 19 patients MTC 6 primary parathyroid adenoma for at by restriction analysis PCR-amplified product sequence 10 11. A Cys634-->Tyr mutation was found both tumoral one...
Amiodarone, an iodine-rich cardiac drug, may induce thyrotoxicosis (AIT), which can occur in patients with preexisting thyroid abnormalities and subjects apparently normal glands. The pathogenesis of AIT is often due to iodine-induced excessive hormone synthesis, especially underlying disease. In some instances, however, be related a destructive process amiodarone-induced thyroiditis, resulting cell damage release into the circulation. Another inflammatory process, subacute has been recently...
The relationship between thyroid dysfunction and breast cancer (BC) is debated. To clarify this controversial issue, a prospective study on function in BC was performed. prevalence of disease examined 102 consecutive patients with ductal infiltrating carcinoma after surgery before starting any chemohormonal or x-ray therapy 100 age-matched control healthy women living the same borderline iodine-sufficient geographic area. All subjects were submitted to clinical ultrasound evaluation serum...
Amiodarone, an iodine-rich drug widely used for the treatment of cardiac tachyarrhythmias, may induce either hyperthyroidism or hypothyroidism. Of 467 patients chronically treated with this referred to our institution, amiodarone iodine-induced hypothyroidism (AIIH) developed in 28 (6%). AIIH were subdivided into two groups according presence (group A) absence B) underlying thyroid abnormalities. Thyroid autoantibodies present 10 19 from group A and 0 9 B. The 24-h radioiodine uptake (RAIU)...
The concentration of thyrotropin-releasing hormone (TRH, thyroliberin) in rat islets Langerhans is 30-fold higher than whole pancreas, indicating that the are main source pancreatic TRH. TRH extracted from indistinguishable synthetic its immunological and biological properties inactivation by human serum. physiologic function islet unknown. However, because antagonistic to somatostatin other systems, also concentrated high concentrations, it possible may serve a similar regulation cell...
Recent observations have shown the presence of thyrotropin-releasing hormone-like material (TRH-LM) in rat pancreatic islets and retina. Its immunological biological properties are identical to those synthetic hormone (thyroliberin). This communication deals with ontogenesis TRH-LM pancreas retina as compared that hypothalamus. Effects sex exposure constant dark were also studied. Results show asynchronous changes concentration occur during postnatal maturation these tissues, presumably...
Thyroid function was evaluated in 150 Sardinian outpatients at different stages of lithium treatment. A visible and/or palpable goitre found 51% patients, and there no apparent correlation with the duration No cases symptomatic hypothyroidism were observed, but subclinical present 19% patients. The prevalence specific antithyroid antibodies positively correlated age treatment, higher women. Subclinical observed 53% antibody-positive lithium-treated Carbamazepine combination associated...
Objective Abnormalities of glucose metabolism are common findings acromegaly. However, robust evidence on whether therapy with somatostatin analogs (SSAs) or pegvisomant (PEG) differently affects is lacking. The purpose this study was to evaluate the effects SSAs, PEG, their combination in a large series acromegalic patients. Design This historical–prospective study. Among 50 consecutive patients under SSA therapy, acromegaly 19 controlled. PEG used allowed control remaining 31 and then...
The relationship among iodine intake, goiter prevalence, and thyroid autoimmunity remains controversial. In the present article, we report prevalence of antithyroid antibodies (ATA) in relation to frequency goiter, function a large group Sardinian schoolchildren living areas with borderline sufficiency, or mild moderate deficiency. A total 8,040 (4,194 males, 3,846 females, ages 6-15 years) from 29 communities were examined between 1986-1994. Thyroid size was assessed by palpation, according...