A5060422691- Eating Disorders and Behaviors
- Obesity and Health Practices
- Obsessive-Compulsive Spectrum Disorders
- Body Image and Dysmorphia Studies
- Impact of Technology on Adolescents
- RNA modifications and cancer
- School Health and Nursing Education
- Bariatric Surgery and Outcomes
- Cognitive Abilities and Testing
- DNA and Nucleic Acid Chemistry
- Psychological and Temporal Perspectives Research
- Airway Management and Intubation Techniques
- Olfactory and Sensory Function Studies
- Community Health and Development
- Simulation-Based Education in Healthcare
- Mindfulness and Compassion Interventions
- RNA and protein synthesis mechanisms
- Mental Health Research Topics
- Cancer, Hypoxia, and Metabolism
- Advanced biosensing and bioanalysis techniques
- Public Health Policies and Education
- Glioma Diagnosis and Treatment
- Prion Diseases and Protein Misfolding
- Body Contouring and Surgery
- Anesthesia and Pain Management
University of California, San Diego
2022
Penn State Milton S. Hershey Medical Center
2020-2021
University of Hawaiʻi at Mānoa
2016-2021
University of Hawaii System
2019
Yale University
2015-2018
Rutgers, The State University of New Jersey
2018
University of Iowa
2016
Virginia Commonwealth University
2013
University of North Carolina at Chapel Hill
2009
Despite significant progress, a disease-modifying therapy for Alzheimer's disease (AD) has not yet been developed. Recent findings implicate soluble oligomeric amyloid beta as the most relevant protein conformation in AD pathogenesis. We recently described signaling cascade whereby binds to cellular prion on neuronal cell surface, activating intracellular Fyn kinase mediate synaptotoxicity. implicated pathophysiology both vitro models and human subjects, is promising new therapeutic target...
Objective: To assess the effects of social media consumption on body dissatisfaction and negative affect using ecological momentary assessment, a method assessment over time in participants' naturalistic environment. Participants: Woman college students (N = 30) from large public university participated study Fall 2015. Methods: Participants were contacted via their smartphones five times per day for days asked to complete battery measures which assessed use, dissatisfaction, affect....
This study evaluated the effect of alpha-2A-adrenoceptor agonist guanfacine on prefrontally mediated cognitive functions, as well quality life and global function in healthy older participants. One hundred twenty-three participants aged 75 years were randomly assigned to 0.5 mg, 0.1 or placebo daily for 12 weeks. The primary outcome measure was change z-score 6 prefrontal executive tasks over weeks (PEF6). Neither dose improved PEF6 relative placebo. rate mean (95% confidence interval) 0.270...
Abstract Objective The role of family and caregiver accommodation is a well‐defined maintenance factor for anxiety disorders OCD. Family patients with eating beginning to be described characterized, but gaps in the literature remain. current project compares levels families those anorexia nervosa (AN) avoidant/restrictive food intake disorder (ARFID). It additionally establishes whether changes over course treatment extent which these are related pathology. Methods A total 39 adolescents...
Internalized weight bias is associated with body image disturbances and the development of disordered eating. The association between internalization dissatisfaction has proven difficult to disrupt. In order develop more effective interventions, we must identify behavioral targets which account for this robust association. present study sought examine whether checking avoidance mediate relationship dissatisfaction. total, 279 female undergraduates (Mage = 20.13, SD 4.10) were administered a...
Objective: The current study aimed to compare endorsement of the muscular- and thin-ideals alone, as well simultaneous both representative fit-ideal examine potential negative correlates each type ideal internalization. Participants: Participants were 300 female undergraduate students. Methods: completed measures internalization thin- muscular-ideals, body dissatisfaction, checking, avoidance. Results: Analyses revealed that approximately 24.9% participants endorsed scores in upper quartile...
Background: In recent years, bariatric surgery has proven to be a leading medical intervention help patients meet their weight loss goals. While the is an effective tool can use in addition lifestyle modifications, there have been inconsistent outcomes effect of on psychopathology and quality life. Additionally, few studies explored patient experience with regard body image for undergoing surgery. Methods: To evaluate this phenomenon, we conducted semistructured focus groups both male female...
Little is known about patients' perceptions toward open and blind weighing for eating disorders. Upon admission to a partial hospitalization program, 35 child/adolescent patients, 55 adult 36 parents of patients completed questionnaires assessing attitudes weighing. Participants perceived as more effective in the short term. No differences emerged on measures preference, credibility, or long-term effectiveness. Relative adults, preferred weighing, child/adolescents credible. On forced-choice...
Regional anesthesia is commonly performed for orthopedic operations, especially in situations when general preferably avoided. Anesthesia residents should understand the complications of regional procedures and know how to treat them if treatment warranted. This simulation involves a 60-year-old man who became apneic beach-chair position following an interscalene block rotator cuff repair. It presents trainees with opportunity further their learning regard perioperative management associated...
Abstract Glioblastoma multiforme (GBM) is a lethal brain cancer with life expectancy of only 12-15 months. Current standard treatment for GBM surgery and chemoradiation. However, there are many difficulties when it comes to treating this aggressive due the inherent radio- chemo-resistance. Consequently, critical need new therapeutic approaches make radiation/chemotherapy more effective. Ataxia telangiectasia (A-T) patients extremely sensitive ionizing radiation. The protein mutated in A-T,...
The role of public health leaders in shaping decision- and policymaking remains a critical task that encompasses many qualities. current report attempts to capture the perspectives about this from those working community Hawai‘i. Methods: This is qualitative descriptive study design. Participants (n=115; 84.3% female; mean age=42.3 [SD = 12.3] years) generated lists qualities they identified as for leadership developed definitions leader. Data were coded thematically. Rating differences...
Abstract Macrophages are the primary host cell that supports survival and replication of intracellular bacterial pathogen Mycobacterium tuberculosis (Mtb). We interested in how macrophage proteins functionalized during Mtb infection. Global proteomics analysis Mtb-infected macrophages found many RNA binding Serine/Arginine rich splicing family (SRSF) can be differentially phosphorylated, suggesting these factors regulate decisions Knockdown one such SRSF protein, called SR6, results basal...
Abstract To defend against invading pathogens, the macrophage innate immune response requires rapid, robust gene expression reprogramming. Innate genes that are induced as part of this regulated at many steps. While transcriptional activation has been extensively studied, mechanisms driving their post-transcriptional regulation (i.e. alternative splicing) needs further investigation. begin learning how pre-mRNA splicing changes impact in macrophages, we examined loss a regulatory protein...