A5103096840- RNA Research and Splicing
- Animal Virus Infections Studies
- Viral gastroenteritis research and epidemiology
- Viral Infections and Immunology Research
- Virus-based gene therapy research
- Heat shock proteins research
- Endoplasmic Reticulum Stress and Disease
- interferon and immune responses
- Viral Infections and Vectors
- CRISPR and Genetic Engineering
- RNA modifications and cancer
- Viral Infectious Diseases and Gene Expression in Insects
- Microbial infections and disease research
- Insect symbiosis and bacterial influences
- Respiratory viral infections research
- Mosquito-borne diseases and control
- Animal Disease Management and Epidemiology
- Aquaculture disease management and microbiota
Heidelberg University
2017-2022
University of California, Davis
1991-1992
Veterinary Medical Teaching Hospital
1991
ABSTRACT As obligate parasites, viruses strictly depend on host cell translation for the production of new progeny, yet infected cells also synthesize antiviral proteins to limit virus infection. Modulation therefore represents a frequent strategy by which optimize their replication and spread. Here we sought define how is regulated during infection human with dengue (DENV) Zika (ZIKV), two positive-strand RNA flaviviruses. Polysome profiling analysis de novo protein synthesis revealed that...
Stress granules (SGs) are formed in the cytosol as an acute response to environmental cues and activation of integrated stress (ISR), a central signaling pathway controlling protein synthesis. Using chronic virus infection model, we previously uncovered unique temporal control ISR resulting recurrent phases SG assembly disassembly. Here, elucidate molecular network generating this fluctuating by integrating quantitative experiments with mathematical modeling find that operates stochastic...
Viral infections impose major stress on the host cell. In response, pathways can rapidly deploy defence mechanisms by shutting off protein synthesis machinery and triggering accumulation of mRNAs into granules to limit use energy nutrients. Because this threatens viral gene expression, viruses need evade these propagate. Human norovirus is responsible for gastroenteritis outbreaks worldwide. Here we examined how interacts with eIF2α signaling axis controlling translation granules. While...
Mycoplasma synoviae (MS) was isolated from the brains of 22-week-old commercial meat turkeys displaying severe synovitis and infrequent central nervous system signs. Histological examination revealed mild-to-severe meningeal vasculitis. The vasculitis ranged fibrinoid necrosis with little inflammation to a marked infiltration lymphocytes plasma cells disrupting architecture vessel wall, accumulating as perivascular cuffs, involving surrounding meninges. Occasional arteries were undergoing...
A retrospective study was conducted to evaluate the temporal relationship between flock seroconversion hemorrhagic enteritis virus (HEV) and appearance of adenoviral inclusions in spleen renal tubular epithelium. The on samples turkey poults submitted Fresno Branch California Veterinary Diagnostic Laboratory System during May December 1988. included 78 submissions (four eight per submission) ages ranging from 6 15 weeks. Sera were tested for antibodies HEV using agar gel immunodiffusion...
ABSTRACT During viral infection, the accumulation of RNA replication intermediates or proteins imposes major stress on host cell. In response, cellular pathways can rapidly impose defence mechanisms by shutting off protein synthesis machinery, which viruses depend on, and triggering mRNAs into granules to limit use energy nutrients. Because this threatens gene expression, need evade these propagate. Human norovirus is responsible for gastroenteritis outbreaks worldwide. Previously we showed...
Turkey viral hepatitis (TVH) was experimentally reproduced in two experiments 1-day-old poults. In the first experiment, an infectious inoculum prepared from filtered yolk materials harvested dead embryonating chicken eggs (ECE) previously inoculated with suspensions of liver and pancreas tissues collected TVH-affected birds commercial turkey flocks. One-day-old poults given a yolk-sac inoculation or oral gavage this preparation developed lesions characteristic TVH at 20 days postinoculation...
Viral infections impose major stress on the host cell. In response, pathways can rapidly deploy defence mechanisms by shutting off protein synthesis machinery and triggering accumulation of mRNAs into granules to limit use energy nutrients. Because this threatens viral gene expression, viruses need evade these propagate. Human norovirus is responsible for gastroenteritis outbreaks worldwide. Here we examined how interacts with eIF2α signaling axis controlling translation granules. While...
Abstract Stress granules (SGs) are formed in the cytosol as an acute response to environmental cues and activation of integrated stress (ISR), a central signaling pathway controlling protein synthesis. Using chronic virus infection model, we previously uncovered unique temporal control ISR resulting recurrent phases SG assembly disassembly. Here, elucidate molecular network generating this fluctuating response, by integrating quantitative experiments with mathematical modeling, find that...