A5010854846- Congenital heart defects research
- Hemispheric Asymmetry in Neuroscience
- Developmental Biology and Gene Regulation
- Endoplasmic Reticulum Stress and Disease
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Protein Structure and Dynamics
- Enzyme Structure and Function
- RNA and protein synthesis mechanisms
- Heat shock proteins research
- RNA Research and Splicing
National Taiwan University
2020-2021
Goethe University Frankfurt
2016-2018
Protein biogenesis is tightly linked to protein quality control (PQC). The role of PQC machinery in recognizing faulty polypeptides becoming increasingly understood. Molecular chaperones and cytosolic vacuolar degradation systems collaborate detect, repair, or hydrolyze mutant, damaged, mislocalized proteins. On the other hand, contribution cofactor binding-related enzyme maturation remains largely unexplored, although loading a represents an all-or-nothing transition regard enzymatic...
C-terminal polylysine (PL) can be synthesized from the polyadenine tail of prematurely cleaved mRNAs or when a read-though stop codon happens. Due to highly positive charge, PL stalls in electrostatically negative ribosomal exit channel. The stalled polypeptide recruits Ribosome-associated quality control (RQC) complex which processes and extracts nascent chain. Dysfunction RQC leads accumulation PL-tagged proteins, induction stress response, cellular toxicity. Not much is known about...
Cells respond to protein misfolding and aggregation in the cytosol by adjusting gene transcription a number of post-transcriptional processes. In parallel functional reactions, cellular structure changes as well; however, mechanisms underlying early adaptation compartments cytosolic are less clear. Here we show that mammalian ubiquitin ligase C-terminal Hsp70-interacting (CHIP), if freed from chaperones during acute stress, can dock on membranes thus performing proteostasis sensor function....
The conserved bilateral habenular nuclei (HA) in vertebrate diencephalon develop into compartmentalized structures containing neurons derived from different cell lineages. Despite extensive studies demonstrated that zebrafish larval HA display distinct left-right (L-R) asymmetry gene expression and connectivity, the spatial domains were mainly obtained two-dimensional (2D) snapshots of colorimetric RNA situ hybridization staining which could not properly reflect neuronal lineages constructed...
ABSTRACT The conserved bilateral habenular nuclei (HA) in vertebrate diencephalon develop into compartmentalized structures containing neurons derived from different cell lineages. Despite extensive studies demonstrated that zebrafish larval HA display distinct left-right (L-R) asymmetry gene expression and connectivity, the spatial domains were mainly obtained two-dimensional (2D) snapshots of colorimetric RNA situ hybridization staining which could not properly reflect neuronal lineages...