A5028756115- Analytical chemistry methods development
- Analytical Chemistry and Chromatography
- Forensic Toxicology and Drug Analysis
- Mass Spectrometry Techniques and Applications
- Metabolomics and Mass Spectrometry Studies
- Analytical Methods in Pharmaceuticals
- Pesticide Residue Analysis and Safety
- Advanced Chemical Sensor Technologies
- Biochemical and Molecular Research
- Cardiovascular and Diving-Related Complications
- Adenosine and Purinergic Signaling
- High Altitude and Hypoxia
- Electrochemical Analysis and Applications
- Cardiac electrophysiology and arrhythmias
- HIV/AIDS drug development and treatment
- Microfluidic and Capillary Electrophoresis Applications
- Inflammatory mediators and NSAID effects
- Poisoning and overdose treatments
- Forensic Entomology and Diptera Studies
- Biosensors and Analytical Detection
- Heat shock proteins research
- Forensic Fingerprint Detection Methods
- Indoor Air Quality and Microbial Exposure
- Phosphodiesterase function and regulation
- Mycobacterium research and diagnosis
Ospedale di Santo Spirito
2019-2024
Azienda USL di Pescara
2020
University of Chieti-Pescara
1990-2006
Weatherford College
2001
Sapienza University of Rome
1991
This study introduces an innovative device for the noninvasive sampling and chromatographic analysis of different compounds present in exhaled breath aerosol (EBA). The new device, especially light recent COVID-19 pandemic that forced many countries to impose mandatory facemasks, allows easy monitoring subject's exposure they may come contact with, actively or passively. project combines advantages a fabric-phase sorptive membrane (FPSM) as vivo with validated LC-MS/MS screening procedure...
In recent years, major attention has been focused on microextraction procedures that allow high recovery of target analytes, regardless the complexity sample matrices. The most used techniques included liquid-liquid extraction (LLE), solid-phase (SPE), (SPME), dispersive (DLLME), by packed sorbent (MEPS), and fabric-phase sorptive (FPSE). These manifest a rapid development preparation in different fields, such as biological, environmental, food sciences, natural products, forensic medicine,...
The primary cause of poor and ambiguous results obtained from the bioanalytical process is sample pre-treatment, especially in clinical analysis because it involves dealing with complex matrices, such as whole blood, urine, saliva, serum, plasma. So, aim this review to focus attention on classical new techniques pre-treatment for biological samples used process. We discussed methods generally these types samples. Undoubtedly, a daunting task deal analyst may encounter substantial loss...
One of the most discussed topics concerns sample preparation before analysis and, therefore, all operations necessary to eliminate interferents, clean up specimens, and extract analytes interest, reducing matrix effect. This review highlights fundamental steps in treatment postmortem samples used forensic analysis. Through critical literature research, it was possible choose among countless works that could provide a general overview state-of-the-art this field. Different biological matrices...
The treatment of biological samples, especially from complex matrices, has consistently challenged analytical operators. classic problems to be faced for any analysis, regardless the origin sample, such as example contamination and loss analyte, in are particularly emphasized. In particular, main cause error is due degradation analyte which several cases interaction. Many factors can influence stability drugs, chief among them physicochemical properties drug, characteristics matrix, tendency...
Nowadays it is increasingly important from a pharmacological, toxicological, and clinical point of view to have rapid reliable screening tests available for the analysis numerous compounds in very short time. Often these procedures involve innovative eco–friendly extraction purification techniques, but necessary apply preliminary steps such as protein precipitation (plasma or whole blood) enzymatic hydrolysis, obtain quantitative dosage also metabolites (urine). In this work procedure liquid...
Ethanol (ethylic alcohol) represents the most commonly used drug worldwide and is often involved in clinical forensic toxicology. Based on several reports, excessive alcohol consumption main contributing factor traffic accidents, drownings, suicides, other crimes. For these reasons, it becomes essential to analyze concentration during autopsy. Although blood usually for analysis post-mortem cases, could suffer alterations, putrefaction, microbial contaminations. As an alternative whole...
Narcotic and psychotropic substances are natural, synthetic, or semisynthetic compounds that present in both solid liquid illicit products. The alterations effects on the central nervous system related to their use can be psycholeptic, psychoanaleptic, psychodiseptic able generate tolerance, addiction, dependence phenomena, creating social public order problems. In this scenario, analytical evaluations aim determine these analytes seized nonbiological samples, which assume character of...
The quantification and interpretation of drug concentrations in biological matrices to optimize pharmacotherapy perform the therapeutic monitoring (TDM) is particularly important for compounds with narrow ranges, known cause adverse effects. In these cases, biomonitoring essential avoid toxicity side this study, an innovative Fabric Phase Sorptive Extraction (FPSE) followed by high performance liquid chromatography-photodiode array detection (FPSE–HPLC–PDA) method was optimized validated...
Background: Ionic liquids (ILs) are a unique class of compounds consisting exclusively cations and anions that possess distinctive properties such as low volatility, high thermal stability, miscibility with water organic solvents, electrolytic conductivity non-flammability. have been defined "design solvents", because it is possible to modify their physical chemical by appropriately choosing anions, in order meet the specific characteristics based on potential application. Introduction: Due...
Effect of in-water oxygen prebreathing at different depths on decompression-induced bubble formation and platelet activation in scuba divers was evaluated. Six volunteers participated four diving protocols, with 2 wk recovery between dives. On dive 1, before diving, all breathed normally for 20 min the surface sea (Air). 2, 100% [normobaric oxygenation (NBO)]. 3, O 6 m seawater [msw; hyperbaric (HBO) 1.6 atmospheres absolute (ATA)]. 4, 12 msw (HBO 2.2 ATA). Then they dove to 30 (4 ATA)...
In this work, the synthesis, characterization, and application of novel parabens imprinted polymers as highly selective solid-phase extraction (SPE) sorbents have been reported. The were created using sol-gel molecular imprinting process. All seven considered herein in order to check phase selectivity. By means a validated HPLC-photodiode array detector (PDA) method all resolved single chromatographic run 25 min. These SPE sorbents, in-house packed empty cartridges, first characterized terms...
Nowadays, the challenges in analytical chemistry, and mostly quantitative analysis, include development validation of new materials, strategies procedures to meet growing need for rapid, sensitive, selective green methods. In this context, considering constantly updated International Guidelines, constant innovation is mandatory both pre-treatment instrumental configurations obtain reliable, true, reproducible information. additionally classic plasma (or serum) matrices, biopsies, whole...
Background: Alcohol abuse is one of the most common causes mortality worldwide. This study aimed to investigate efficacy a treatment in reducing circulating ethanol and oxidative stress biomarkers. Methods: Twenty wine-drinking subjects were investigated randomized controlled, single-blind trial (ClinicalTrials.gov. Identifier: NCT06548503; Ethical Committee University Padova (HEC-DSB/12-2023) evaluate effect intake product containing silymarin, pyrroloquinoline quinone sodium salt,...
Hyperthermia produces regression of human cancer. Because hyperthermia has produced only limited results, attention focused on searching for substances able to sensitize tumour cells the effects hyperthermia. The flavonoid quercetin been reported be a hyperthermic sensitizer in ovarian and uterine cervical tumours leukaemia. Quercetin tamoxifen inhibit melanoma cell growth. We therefore investigated whether can M10, M14 MNT1 observed that both synergize with (42.5 degrees C) reducing...