A5061156929- Acute Lymphoblastic Leukemia research
- Acute Myeloid Leukemia Research
- Epigenetics and DNA Methylation
- Platelet Disorders and Treatments
- Blood groups and transfusion
- Chemotherapy-induced cardiotoxicity and mitigation
- Chronic Myeloid Leukemia Treatments
- Monoclonal and Polyclonal Antibodies Research
- Renal and related cancers
- HIV/AIDS drug development and treatment
- Otitis Media and Relapsing Polychondritis
- Liver Disease and Transplantation
- Mesenchymal stem cell research
- Pharmacological Effects and Toxicity Studies
- Plant Virus Research Studies
- Hemoglobinopathies and Related Disorders
- Drug Transport and Resistance Mechanisms
- Chronic Lymphocytic Leukemia Research
- Long-Term Effects of COVID-19
- Autoimmune and Inflammatory Disorders Research
- Genomics, phytochemicals, and oxidative stress
- Angiogenesis and VEGF in Cancer
- COVID-19 Clinical Research Studies
- Erythrocyte Function and Pathophysiology
- SARS-CoV-2 and COVID-19 Research
Cairo University
2003-2025
King's College Hospital NHS Foundation Trust
2024
Cairo University hospitals
2024
Abstract Objective Chronic myeloid leukemia (CML) is the first human malignancy that responded to molecular targeted therapy, tyrosine kinase inhibitors (TKIs). Despite strong effect of TKIs on management and outcome CML, several adverse events have been reported. Vascular arterial (VAEs) are serious complications reported with new-generation TKIs. Patient methods We conducted a case-control study including 70 CML patients who were receiving either imatinib or nilotinib 50 age- sex-matched...
Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of antiplatelet antibodies. The current case-control study aimed at detecting frequency FcγRIIa-131H/R and FcγRIIIa-158F/V genes polymorphism in Egyptian children with ITP as genetic markers for risk, to clear out their possible role choosing treatment protocols ITP. To achieve this aim, FcγRIIa genotyping was tested PCR-restriction fragment length (RFLP) technique, whereas FcγRIIIa nested PCR...
Abstract AML1 is among the most frequent targets of chromosomal rearrangements in human leukemias. We report here molecular analysis a t(4;21)(q28;q22) that has disrupted patient with de novo T‐cell acute lymphoblastic leukemia. By using 3′‐RACE analysis, we show this rearrangement results fusion novel gene immediately downstream exon 5 or 6 , indicating breakpoint lies intron and alternative splice variants are generated. The sequence gene, located at 4q28, does not have any significant...
Sickle cell disease (SCD) is associated with a pro-inflammatory state, characterized by an elevated baseline leukocyte count and inflammatory cytokines. Inflammation, white blood (WBC) adhesion to vascular endothelium subsequent endothelial injury, repeated ischemia-reperfusion injury contribute pathogenesis. Identification of genetic polymorphisms that may modulate severity in SCD becoming field interest. The Duffy group antigen has been identified as receptor for various chemokines...
Abstract A serious global public health emergency emerged late November 2019 in Wuhan City, China, by a new highly pathogenic virus, SARS-CoV-2. The virus evolution spread has been tracked three developing databases: GISAID, Nextstrain and PANGO to understand its circulating variants. In this study, 110 diagnosed positive COVID-19 patient’s samples, were collected from Kasr Al-Aini Hospital the Children Cancer Egypt 57357 between May 2020 January 2021, with clinical severity ranging mild...
Primary immune thrombocytopenia is an acquired autoimmune disorder caused by the production of antiplatelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels circulating platelets. The current case-control study aimed at detecting frequency interleukin-23 receptor rs1884444 single nucleotide polymorphism Egyptian children with primary and its possible role as a genetic marker disease risk. Interleukin-23 was studied 50 patients 100 healthy age...
Polyserositis, characterized by inflammation of multiple serous membranes, frequently occurs secondary to infection, malignancy, or rheumatological disorders. Adult-onset Still's disease (AOSD) is often diagnosed exclusion, with the Yamaguchi criteria being essential for diagnosis. Disease severity likely due immune system changes, comorbidities, delayed diagnosis, and a higher risk complications, necessitating more aggressive carefully monitored treatments. We report case an elderly male...
SALL4 is a transcription factor that retains stem cells in an undifferentiated state and promotes its self-renewal. In addition, it implicated leukemogenesis via effect on leukemic cells. This study aimed to characterize the expression pattern of gene acute myeloid leukemia (AML) chronic (CML) at different progression phases process assess prognostic significance. Real-time PCR was used 106 patients: 54 AML patients; 43 de novo 11 complete remission (CR), 52 CML 31 phase (CP), deep molecular...
Objectives: B-cell specific moloney murine leukemia virus integration site-1 (BMI-1) gene is a stem cell that modulates pluripotency and also implicated in the regulation accumulation of leukemic cells (LSCs). The current study aimed at characterizing BMI-1 expression de novo AML patients before start chemotherapy those who achieved complete remission (CR). Methods: Real-time polymerase chain reaction was used to assess 54 patients: 43 11 CR as well 21 non malignant bone marrow...